基于网络药理学探究补阳还五汤治疗颈椎病的作用机制

目的：基于网络药理学与分子对接技术分析补阳还五汤治疗颈椎病的作用机制。方法：使用TCMSP、化学专业数据库获取补阳还五汤的活性成分,并对潜在靶点进行预测及规范。分别从PharmGKB、DisGeNET、OMIM、GeneCards数据库中得到颈椎病疾病靶点,利用韦恩图获取补阳还五汤与颈椎病的交集靶点。通过CytoScape软件构建中药-活性成分-疾病靶点和蛋白质-蛋白质相互作用（PPI）网络,获得核心有效成分与关键靶点,利用David数据库对潜在靶点进行富集分析。最后运用AutoDock Vina软件对补阳还五汤核心有效成分与关键靶点进行分子对接验证。结果：共获得补阳还五汤治疗颈椎病的有效活性成分97个,包括槲皮素、山柰酚、黄芩素、木犀草素等;交集靶点64个,关键靶点有白细胞介素-6（IL-6）、肿瘤坏死因子（TNF）、丝氨酸/苏氨酸蛋白激酶1（AKT1）、白细胞介素-1B（IL-1B）等;主要涉及肿瘤坏死因子（TNF）、白细胞介素-17（IL-17）、磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（Akt）等信号通路,分子对接结果显示核心有效成分与关键靶点之间结合紧密,为补阳还五汤治疗颈椎病提供相应条件。结论：该研究在总体上预测了补阳还五汤治疗颈椎病的活性成分、靶点和信号通路,作用途径广泛,为下一步的临床应用提供参考及思路。     

不规则波折射物理模型试验研究

作者曾发表过“不规则波折射的数学模型〔１〕。为了与数学模型的计算结果相互验证，在大连理工大学海岸及近海工程国家重点实验室进行了不规则波折射物理模型试验。试验研究结果表明：提出的“不规则波折射数学模型”对频谱采用等能量分割、对方向分布采用等间隔（Δθ＝ｃｏｓｎｔ）分割的组成波折射线性叠加法是合理的、可行的，可供港口及海岸工程规划、设计应用     

A Numerical Study on the Structure and Dynamics of Turbulence in Oscillatory Bottom Layer Flow over A Flat or Rippled Bed

1 .IntroductionUnder the influence of surface waves ,sandripples often appear on beaches . Whenthe amplitudeof water oscillationis sufficientlylarge ,vortices are formed onthe lee of every sand ripple crest . A-mongthese vortices ,the most important are t…     

波浪作用下海床的有效应力分析

波浪作用下海床的稳定性分析是海洋工程地质评价的重要内容。海床的稳定性可通过计算分析其随时间变化的有效应力场来评估。本文建议了一个周期荷载作用下土体的本构模型 ,并用于计算波浪作用下海床的应力与变形。采用Biot固结理论和有限单元法 ,分析了海床的动态应力场与孔隙水压力场。波浪作用下两种渗透系数时有效应力的动态变化过程结果对比 ,反映了渗透消散作用对海床有效应力变化的影响     

深圳河河口围垦对防洪和河床冲淤影响研究

为研究深圳河河口福田保税区围垦填土占用部分河道对深圳河治理工程的影响 ,建立了贴体坐标系下平面二维的深圳河河道 -河口 -海湾整体水域的水流泥沙数学模型 ,计算了不同频率洪峰流量和河口潮位过程组合下河口围垦所造成的深圳河沿程水位抬高程度和河床冲淤变化情况 ,提出了建议的挖除方案     

Circulation and Brackish Water Dispersal in a Coastal Lagoon of Southwest Taiwan

Modest observations and numerical experiments were conducted to investigate circulation and brackish water dispersal in a coastal lagoon southwest of Taiwan. The Chi-Ku Lagoon, partially shielded from the sea by a string of sandbar barriers with two entrances among them, receives modest and episodic runoff from Chi-Ku Stream. Flood and ebb tidal streams entering and leaving the two entrances are found to converge and diverge in a flow stagnation area inside the lagoon. Under weak wind conditions, brackish water is preferentially retained in the flow stagnation area. Besides the observations, scenario runs using a three-dimensional numerical model also indicate strong modulation by monsoon winds. Both summer southwest monsoon and winter northeast monsoon reduce brackish water retention; the latter is found to be more effective. This revised version was published online in August 2006 with corrections to the Cover Date.     

A new efficient 3D non-hydrostatic free-surface flow model for simulating water wave motions

A new three-dimensional, non-hydrostatic free surface flow model is presented. For simulating water wave motions over uneven bottoms, the model employs an explicit project method on a Cartesian the staggered gird system to solve the complete three-dimensional Navier–Stokes equations. A bi-conjugated gradient method with a pre-conditioning procedure is used to solve the resulting matrix system. The model is capable of resolving non-hydrostatic pressure by incorporating the integral method of the top-layer pressure treatment, and predicting wave propagation and interaction over irregular bottom by including a partial bottom-cell treatment. Four examples of surface wave propagation are used to demonstrate the capability of the model. Using a small of vertical layers (e.g. 2–3 layers), it is shown that the model could effectively and accurately resolve wave shoaling, non-linearity, dispersion, fission, refraction, and diffraction phenomena.