基于数据挖掘探讨中药治疗肝豆状核变性的用药规律

目的：基于数据挖掘探讨中药治疗肝豆状核变性的用药规律。方法：计算机检索1990年1月至2020年1月中国知网（CNKI）、万方数据（WANFANG DATA）、维普中文科技期刊数据库（VIP）中中药治疗肝豆状核变性的相关文献,利用Microsoft Excel 2010 进行频次分析,通过 SPSS Modeler 18.0、SPSS Statistics 23.0 对处方药物进行关联规则、复杂网络、系统聚类分析。结果：最终纳入文献161篇,筛选出处方151首,中药70味。中药频次排前5位的依次是泽泻、姜黄、大黄、黄连、丹参;功效排前5位的依次是利水渗湿、活血化瘀、清热、补虚、泻下药。二项关联多为利水渗湿、活血化瘀、清热、泻下药的组合,三项关联多为活血化瘀、清热、利水渗湿药的组合。聚类分析得到新方聚类的中药组合3类。结论：中医药治疗肝豆状核变性以清热化湿、活血化瘀为主,常用利水渗湿、活血化瘀、清热药,可配伍补虚及泻下药等。     

2004年苏门答腊地震前后海面高趋势的变化

利用苏门答腊附近海域T/P、Jason-1测高卫星近20年的海面高连续观测资料,分别计算了该区域(80°E~105°E,5°S~20°N)在2004年苏门答腊大地震前后的海面高变化趋势,并与该区域对应时间段GRACE重力卫星反演的地表质量迁移结果进行比较。研究结果表明,由卫星测高观测资料估算的震区地震前后海平面趋势的变化与卫星重力反演结果基本一致。由于卫星测高沿轨观测具有高精度、高时空分辨率的特性,卫星测高资料估算的海平面趋势变化可以更为准确地反映震区海平面变化的局部特征。还对该区域震后形变特征进行了初步分析。     

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Evaluation of Three Harvest Control Rules for Bigeye Tuna（Thunnus obesus） Fisheries in the Indian Ocean

The stock of Bigeye tuna（Thunnus obesus） in the Indian Ocean supports an important international fishery and is considered to be fully exploited. The responsible management agency, the Indian Ocean Tuna Commission（IOTC）, does not have an explicit management decision-making framework in place to prevent over-fishing. In this study, we evaluated three harvest control rules, i） constant fishing mortality（CF）, from 0.2 to 0.6, ii） constant catch（CC）, from 60000 to 140000 t, and iii） constant escapement（CE）, from 0.3 to 0.7. The population dynamics simulated by the operating model was based on the most recent stock assessment using Stock Synthesis version Ⅲ（SS3）. Three simulation scenarios（low, medium and high productivity） were designed to cover possible uncertainty in the stock assessment and biological parameters. Performances of three harvest control rules were compared on the basis of three management objectives（over 3, 10 and 25 years）： i） the probability of maintaining spawning stock biomass above a level that can sustain maximum sustainable yield（MSY） on average, ii） the probability of achieving average catches between 0.8 MSY and 1.0 MSY, and iii） inter-annual variability in catches. The constant escapement strategy（CE=0.5）, constant fishing mortality strategy（F=0.4） and constant catch（CC=80000） were the most rational among the respective management scenarios. It is concluded that the short-term annual catch is suggested at 80000 t, and the potential total allowable catch for a stable yield could be set at 120000 t once the stock had recovered successfully. All the strategies considered in this study to achieve a ‘tolerable＇ balance between resource conservation and utilization have been based around the management objectives of the IOTC.     

Study on deformation law of circular foundation under combined loading

The foundations of some ocean engineering structures are built to withstand not only the vertical gravity load V, but also the horizontal load H induced by sea waves and current. The horizontal load includes the concentrated force load, the moment load M, and the torque load T termed also as combined loading. It is of academic and engineering significance to study the deformation law of submarine seabed due to combined loading. On the basis of the three-dimensional elastic mechanics solution of circular foundation, numerical methods are used to analyze the deformation law of submarine soil under circular foundation with six degrees of freedom. The finite element analysis results give the elastic deformation law of soil in three dimensional spaces, modify the theoretical elasticity solution, and presents nonlinear soil deformation mechanism under the circular foundation with six degrees of freedom.     

Evaluation of three harvest control rules for Bigeye Tuna (Thunnus obesus) fisheries in the Indian Ocean

The stock of Bigeye tuna(Thunnus obesus) in the Indian Ocean supports an important international fishery and is considered to be fully exploited. The responsible management agency, the Indian Ocean Tuna Commission(IOTC), does not have an explicit management decision-making framework in place to prevent over-fishing. In this study, we evaluated three harvest control rules, i) constant fishing mortality(CF), from 0.2 to 0.6, ii) constant catch(CC), from 60000 to 140000 t, and iii) constant escapement(CE), from 0.3 to 0.7. The population dynamics simulated by the operating model was based on the most recent stock assessment using Stock Synthesis version Ⅲ(SS3). Three simulation scenarios(low, medium and high productivity) were designed to cover possible uncertainty in the stock assessment and biological parameters. Performances of three harvest control rules were compared on the basis of three management objectives(over 3, 10 and 25 years): i) the probability of maintaining spawning stock biomass above a level that can sustain maximum sustainable yield(MSY) on average, ii) the probability of achieving average catches between 0.8 MSY and 1.0 MSY, and iii) inter-annual variability in catches. The constant escapement strategy(CE=0.5), constant fishing mortality strategy(F=0.4) and constant catch(CC=80000) were the most rational among the respective management scenarios. It is concluded that the short-term annual catch is suggested at 80000 t, and the potential total allowable catch for a stable yield could be set at 120000 t once the stock had recovered successfully. All the strategies considered in this study to achieve a ‘tolerable' balance between resource conservation and utilization have been based around the management objectives of the IOTC.     

斜压罗斯贝变形半径优化的误差相关尺度及其对最优插值效果的改进

利用最优插值方法进行三维温盐场重构时,如何正确估算背景场误差协方差至关重要。针对背景场误差协方差主要取决于误差相关尺度的问题,本文提出了用中国东部海域及其附近海域的最新的高分辨率气候态数据进行斜压罗斯贝变形半径优化其误差相关尺度计算的研究方案和技术途径;对比分析了均一化相关尺度方案和法国ISAS系统尺度方案,讨论了变形半径对最优插值的影响。结果表明:均一化相关尺度方案的均方根误差小于ISAS方案,但温度场过于平滑,难以刻画一些重要的物理现象;相比而言,本文提出的基于变形半径的相关尺度方案在取2倍变形半径时,不仅均方根误差在各水平层较小,且温度场能够更好地刻画四国海盆海域涡旋及黑潮影响的温度场三维结构。由于实际海洋中各层物理过程的尺度存在差异,实际应用时各层的最优尺度设置也应有所不同。