Biodegradability of the Anti-tumour Agents 5-Fluorouracil,Cytarabine, and Gemcitabine: Impact of the Chemical Structure and Synergistic Toxicity with Hospital Effluent

Most anti-tumour agents are known to be carcinogenic, mutagenic, teratogenic, embryotoxic or fetotoxic. Only little is known about the environmental impact of pharmaceuticals. Unmetabolized active substances are excreted and will show up in municipal wastewater. Therefore, we examined the biodegradability of the widely used anti-tumour agent 5-fluorouracil (5-FU), also as an example for assessing the impact of hospital effluent on the biodegradation of a test compound. The biodegradability of the structurally similar anti-tumour agents cytarabine and gemcitabine was also examined. Test systems used were the closed bottle test (OECD 301 D) and the modified Zahn-Wellens test (OECD 302 B). 5-FU was not biodegradable in the closed bottle test (CBT) nor in the Zahn-Wellens test (ZWT). At the highest concentration of 5-FU, with hospital effluent an inhibition of the degradation of substances present in hospital effluent was observed, probably as a result of a synergistic effect by 5-FU with antibiotics present in hospital sewage. Gemcitabine was biodegraded 42% in the CBT. The prolongation of the test period to 40 days only improved the result to 45%. In the ZWT, the biodegradation of gemcitabine was 50%. Cytarabine was partially biodegraded in the CBT (50%), but only after an adaptation period of 20 days. After a test prolongation to 40 days, the degree of biodegradation was 80%. In the ZWT, the biodegradability was > 95% after only a few days.     

M5 model tree based modelling of reference evapotranspiration

This paper investigates the potential of M5 model tree based regression approach to model daily reference evapotranspiration using climatic data of Davis station maintained by California irrigation Management Information System (CIMIS). Four inputs including solar radiation, average air temperature, average relative humidity, and average wind speed whereas reference evapotranspiration calculated using a relation provided by the CIMIS was used as output. To compare the performance of M5 model tree in predicting the reference evapotranspiration, FAO–56 Penman–Monteith equation and calibrated Hargreaves–Samani relation was used. A comparison of results suggests that M5 model tree approach works well in comparison to both FAO–56 and calibrated Hargreaves–Samani relations. To judge the generalization capability of M5 model tree approach, model created by using the Davis data set was tested with the datasets of four different sites. Results from this part of the study suggest that M5 model tree could successfully be employed in modeling the reference evapotranspiration. Further, sensitivity analysis with M5 model tree approach suggests the suitability of solar radiation, average air temperature, average relative humidity, and average wind speed as input parameters to model the reference evapotranspiration Copyright © 2009 John Wiley & Sons, Ltd.     

Effect of urbanization on runoff characteristics of the On-Cheon Stream watershed in Pusan,Korea

This study investigated the effect of urbanization on runoff from the On-Cheon Stream watershed in Pusan, Korea. This watershed has been experiencing considerable urbanization since the 1960s. There are two gauging stations in the watershed. For one of the stations there are recent flow data and for the other flow data were observed in the past. A linear reservoir model was chosen and runoff was analysed for several flood events. The linear reservoir model has been found to generate flood hydrographs accurately for both gauging stations, and its applicability to the study area has also been established. Using two methods of computing effective rainfall or rainfall excess (ϕ-index and constant percentage method), the results of runoff analyses were investigated. The ϕ-index method yielded better results than the constant percentage method. A comparison of hydrographs observed in the past with the simulation results at the Ie-Sup bridge site revealed that the peak discharge increased and the mean lag time of the study area decreased owing to urbanization over the past two decades. It is also possible to evaluate the effect of urbanization quantitatively. © 1998 John Wiley & Sons, Ltd.     

2003年新疆石河子5.4级地震前地震活动异常分析

分析了2003年2月14日石河子5．4级地震前北天山地震活动图像和地震学参数异常过程。5．4级地震发生在2002年北天山4级地震集中活动区空段，震前12项地震学参数时间进程存在中、短期异常，3项地震波参数出现短期异常。震前3个月乌鲁木齐震情窗出现超警戒线异常。震前10天震中附近地区地震和震群活动显著。     

鲁东南地区"2004.07"大暴雨中尺度分析与数值模拟

对2004年7月16、17日出现在临沂市的大暴雨过程的进行中尺度分析,应用 MM5v3.6 非静力中尺度模式,用美国 NCEP 再分析资料作初始场,采用双向三重嵌套模式,进行高分辨的数值模拟.分析揭示了这次大暴雨的天气尺度背景和中尺度系统的发生和发展的结构及演变,结果表明高低空急流的有利配合为暴雨过程提供环境条件,大暴雨出现在高空西风急流轴线出口区与低空西南风急流轴向出口区北侧之间;数值模拟看出在强降水产生时,雨区上空存在较强的中-β尺度系统,该系统有强而窄的垂直上升运动、上下垂直的辐散辐合结构,强烈的对流不稳定,在对流层低层还存在对称性不稳定.低空急流提供充沛的水汽,并通过强而窄的上升运动向高层输送.     

中尺度模式中不同对流参数化方案的比较试验

MM5模式中有多种积云参数化方案可供选择,粗细网格采用不同的积云参数化方案对降水预报有一定的影响。采用常用的四种积云参数化方案,粗细网格进行不同配置,对辽东半岛大暴雨过程进行试验发现：细网格信息可以通过嵌套边界向外层传递,影响外层预报结果。细网格选取GR方案比选取AK、BM、KF方案模拟效果好很多;细网格参数化方案不变,粗网格取不同的参数化方案,对细网格的模拟结果差别不大。但选取一个好的参数化方案对细网格的模拟结果会稍有改进。     

河南省X.25分组交换网的建设

介绍了河南省气象台与地市局、国家基本站之间依托于邮电部门的Ｘ．２５分组交换网组建的全省Ｘ．２５分组交换网的设计思想和具体实现。     

Processing of oxidised nitrogen compounds by passage through winter-time orographic cloud

Four case studies are described, from a three-site field experiment in October/November 1991 using the Great Dun Fell flow-through reactor hill cap cloud in rural Northern England. Measurements of total odd-nitrogen nitrogen oxides (NO _y ) made on either side of the hill, before and after the air flowed through the cloud, showed that 10 to 50% of the NO _y , called NO _z , was neither NO nor NO₂. This NO _z failed to exhibit a diurnal variation and was often higher after passage through cloud than before. No evidence of conversion of NO _z to NO₃ ^- in cloud was found. A simple box model of gas-phase chemistry in air before it reached the cloud, including scavenging of NO₃ and N₂O₅ by aerosol of surface area proportional to the NO₂ mixing ratio, shows that NO₃ and N₂O₅ may build up in the boundary layer by night only if stable stratification insulates the air from emissions of NO. This may explain the lack of evidence for N₂O₅ forming NO₃ ^- in cloud under well-mixed conditions in 1991, in contrast with observations under stably stratified conditions during previous experiments when evidence of N₂O₅ was found. Inside the cloud, some variations in the calculated total atmospheric loading of HNO₂ and the cloud liquid water content were related to each other. Also, indications of conversion of NO _x to NO _z were found. To explain these observations, scavenging of NO _x and HNO₂ by cloud droplets and/or aqueous-phase oxidation of NO₂ ^- by nitrate radicals are considered. When cloud acidity was being produced by aqueous-phase oxidation of NO _x or SO₂, NO₃ ^- which had entered the cloud as aerosol particles was liberated as HNO₃ vapour. When no aqueous-phase production of acidity was occurring, the reverse, conversion of scavenged HNO₃ to particulate NO₃ ^-, was observed.     

中尺度模式和新一代天气雷达产品识别云降水方法

介绍一种结合中尺度模式产品和新一代天气雷达产品的云降水识别方法。首先利用中尺度模式(MM5)产品计算得到降水潜力区识别因子,分析降水潜力区。进一步结合新一代天气雷达产品,分析潜力区内云团的降水参数,确定有利于降水的云团。分析结果表明,潜力综合指标对未来可能出现的具有大量水资源的对流性系统具有指示意义,可以用于分析对流性系统的降水潜力;另一方面雷达降水等级是对实际对流云团水资源等级的划分。综合这两者进行降水潜力的分析判别,可以增强降水云的识别能力。     

基于CMIP5模拟的中国区域陆气耦合强度评估及未来情景预估

基于第五次国际耦合模式比较计划(CMIP5)11个模式历史情景的模拟结果计算得到了中国区域夏季的陆气耦合强度并进行集合平均,结果表明,位于半干旱区的华北和内蒙古地区陆气耦合强度相对较强,西部干旱区的陆气耦合强度相对较弱,位于湿润区的中国东北地区东部、长江中下游和西南地区陆气耦合强度最弱。利用上述模式集合平均结果与由NCEP再分析资料和欧洲中心的中期气象预报40年再分析资料(ERA40)计算得到的陆气耦合强度相比较,结果显示这些模式的集合平均与再分析资料NCEP和ERA40的计算结果有较好的一致性。利用历史情景模拟和不同的典型排放路径(RCP),即低排放情景RCP2.6、中排放情景RCP4.5和高排放情景RCP8.5下的模拟结果预估陆气耦合强度未来变化。结果显示:与历史情景相比较,位于湿润区的中国南方地区蒸散发的主要控制因子是温度,在3种排放情景下随着温度上升引起蒸散发增加所导致陆气耦合强度升高;位于青藏高原以及半干旱区的内蒙古大部分地区蒸散发在未来的年际变化幅度减弱导致陆气耦合指数降低;位于西北干旱区陆气耦合强度在RCP2.6和RCP4.5情景上升,然而在RCP8.5情景下陆气耦合强度下降,其原因是在高排放情景下,水汽平流输送明显增强,局地蒸散发异常对空气湿度变化的贡献减弱,导致了陆气耦合强度降低。未来预估结果在中国南方可信度相对较高,从全国来看,在RCP4.5情景下可信度相对较高。