长江口崇明东滩及相邻区域地形演化与驱动因素分析

河口大型滩涂演化关系到航运通畅、生态保护以及近岸工程的安全性，是地貌学和工程界关注的热点。利用单波束测深系统对长江口崇明东滩进行高精度监测，并结合近年来周围环境因素分析其冲淤格局。结果表明:(1) 2011?2017年间崇明东滩和北港北沙基本以淤积为主，北港北汊河槽中央局部形成?2 m心滩，?5 m等深线包络面积基本稳定，整体呈“长高不长大”的格局；(2)海洋来沙是其淤积的主要物源，汊道涨落潮时空分异而形成的两大环流是塑造此地形的主要原因；崇明东滩和北港北沙的淤积直接挤压北港北汊的发展，沙体淤积可能会引起未来两大沙体的并靠；(3)崇明东滩、北支南沿的滩涂整治工程是促进北支萎缩和崇明东滩淤积的重要因素，另外横沙通道落潮分流增加,青草沙围水工程改变了北港河槽的曲率，也有利于北港北沙的淤积。     

2DVAR方法在台湾海峡海表流场融合中的应用

高频地波雷达可以提供沿岸大面积海表流的观测,但单个地波雷达只能提供径向流观测。本研究发展了一套二维变分(Two-Dimensional VARiational Method, 2DVAR)数据融合方法,将台湾海峡海域的地波雷达径向流数据与ROMS (Regional Ocean Model System)模式输出结果进行融合,得到一套较好的融合产品。结果显示,融合产品与雷达径向流的平均相对误差相较于模式输出与雷达径向流的平均相对误差由9.70%降低至1.54%。为进一步检验融合方法,设计了两种独立样本试验。试验一将雷达径向流按空间均匀划分为融合样本与独立样本,使用雷达融合样本与模式输出进行融合,此时融合结果的平均均方根误差(Root Mean Square Error, RMSE)相较于模式输出由0.41 m/s降低至0.19 m/s。试验二将雷达径向流和模式输出在空间上都均匀划分为融合样本与独立样本,对两种数据的融合样本进行融合,使用TC (Triple Collocation)方法估计模式输出、雷达观测与融合结果的误差方差,此时融合结果的平均误差方差最小,且其误差方差相对于独立的雷达径向流与模式输出在远岸处有明显减小。以上结果都表明融合数据更加接近实际海流,证明了2DVAR方法融合海表流的有效性。     

Wave Attenuation Performance and the Influencing Factors of A Lower Arc-Plate Breakwater

Comprehensive experimental and numerical studies have been undertaken to investigate wave energy dissipation performance and main influencing factors of a lower arc-plate breakwater. The numerical model, which considers nonlinear interactions between waves and the arc-plate breakwater, has been constructed by using the velocity wave- generating method, the volume of fluid (VOF) method and the finite volume method. The results show that the relative width, relative height and relative submergence of the breakwater are three main influencing factors and have significant influence on wave energy dissipation of the lower arc-plate open breakwater. The transmission coefficient is found to decrease with the increasing relative width, and the minimum transmission coefficient is 0.15 when the relative width is 0.45. The reflection coefficient is found to vary slightly with the relative width, and the maximum reflection coefficient is 0.53 when the relative width is 0.45. The transmission and reflection coefficients are shown to increase with the relative wave height for approximately 85% of the experimental tests when the relative width is 0.19 0.45. The transmission coefficients at relative submergences of 0.04, 0.02 and 0 are clearly shown to be greater than those at relative submergences of 0.02 and 0.04, while the reflection coefficient exhibits the opposite relationship. After the wave interacts with the lower arc-plate breakwater, the wave energy is mainly converted into transmission, reflection and dissipation energies. The wave attenuation performance is clearly weakened for waves with greater heights and longer periods.     

基于网络药理学探讨抗病毒颗粒治疗呼吸道感染的作用机制

目的：通过网络药理学探讨抗病毒颗粒治疗呼吸道感染的作用靶点及信号通路,并阐述其作用机制。方法：运用TCMSP、TCMID及BATMAN-TCM数据库筛选抗病毒颗粒中中药的主要化学成分及作用靶点,通过UniProt和PubMed等数据库查询靶点对应的基因,使用DisGeNET数据库获取呼吸道感染相关靶点基因,运用Cytoscape 3.7.2软件构建药材-化合物-靶点（基因）-疾病网络,采用STRING数据库创建蛋白相互作用核心网络（PPI）,再通过DAVID数据库进行GO和KEGG分析。结果：抗病毒颗粒中有槲皮素、木犀草素、汉黄芩素、山柰酚等89个活性成分,作用在PTGS2、TNF、AKT1、NOS2、IL-6等靶点蛋白上,通过肿瘤坏死因子（TNF）、核转录因子κB（NF-κB）、低氧诱导因子1（HIF-1）等信号通路发挥抗病毒的治疗作用。结论：抗病毒颗粒治疗呼吸道感染的作用机制可能与其活性化合物通过多靶点、多通路发挥抗病毒、抗炎、免疫调节等作用有关,这为进一步探讨其作用的物质基础以及作用机制提供了参考。     

瓦氏黄颡鱼(Pelteobagrus vachellii)Toll样受体2(TLR2)基因克隆及免疫功能

为探究Toll样受体2(Toll-like receptor 2,TLR2)及下游免疫分子对瓦氏黄颡鱼(Pelteobagrus vachellii)机体的保护作用,本研究采用RT-PCR及RACE法获得瓦氏黄颡鱼TLR2全长c DNA(2611bp),编码789个氨基酸残基,含有10个富含亮氨酸的重复序列(Leucine Rich Repeat,LRR)和Toll/IL-1R(Toll/IL-1 Receptor Domain,TIR)同源区结构域,属I型跨膜受体。序列同源性比对发现,瓦氏黄颡鱼TLR2 c DNA与斑点叉尾、鲤及虹鳟的同源性分别为78%、62%及49%。系统进化树分析表明,瓦氏黄颡鱼TLR2与斑点叉尾聚为一支。q RT-PCR分析表明,TLR2 m RNA在检测的组织中均有表达,且在头肾和脾脏中表达水平显著高于其他组织(P0.05)。嗜水气单胞菌感染能显著上调瓦氏黄颡鱼肝脏、头肾及脾脏中TLR2 m RNA表达(P0.05),分别在24h、48h及12h达到最大值。头肾中的TLR 2信号通路下游的髓样分化因子、半胱氨酸蛋白酶8、核转录因子kappa B、肿瘤坏死因子α、白细胞介素1βm RNA均显著上升(P0.05),分别在24h、12h、48h,48h和48h达到最大值。结果表明,嗜水气单胞菌感染激活了TLR2信号通路,通过上调表达,肿瘤坏死因子α,白细胞介素1β等。本研究表明,TLR2在瓦氏黄颡鱼抵御嗜水气单胞菌侵染的过程中发挥了重要的免疫作用。     

InSAR滑坡探测技术研究——以金沙江乌东德水电站段为例

采用3类InSAR产品和DEM数据开展金沙江流域乌东德水电站段的潜在滑坡探测,成功识别出多处已知和未知的滑坡点,并探测出滑坡体的形态及稳定性,提供了一种高效的大范围滑坡探测技术。同时采用小基线集InSAR技术对金坪子滑坡进行监测,不仅获得该滑坡的空间分区特征,也获取重点滑坡区的时间序列结果,并且与地面监测结果比较,精度达1.8 cm。展示了不同InSAR技术在不同尺度滑坡调查与监测中的应用特点。     

基于Mapbox矢量切片在线配图平台的设计与实现

矢量切片是以四叉树模型切割矢量数据而生成的矢量要素描述性文件,Web GIS开发中,矢量切片的配图是通过编写Json样式文件,最后浏览器根据样式文件实现地图在线渲染显示,但这种方式配图效率低,样式单一。为了优化配图过程,本文从矢量切片数据和浏览器渲染两个方面提出了一套基于Mapbox的矢量切片在线配图平台,包括基于Geo Server的矢量切片服务发布、基于MapboxGL的浏览器地图渲染等,设计实现了矢量切片在线配图平台应用于浙江省电子地图配图与在线制图研究项目,简化了矢量切片地图的配图过程,具有很强的实用性。     

Effects of feeding time on complement component C7 expression in Pelteobagrus vachellii subject to bacterial challenge

Journal of Oceanology and Limnology - Shifting the feeding time for fish from daytime to nighttime could alter their digestive behavior, disturb their metabolism, and may affect immune-related...     

Iron Regulation of Wetland Vegetation Performance Through Synchronous Effects on Phosphorus Acquisition Efficiency

Iron-rich groundwater flowing into wetlands is a worldwide environmental pollution phenomenon that is closely associated with the stability of wetland ecosystems. Combined with high phosphorus(P) loading from agricultural runoff, the prediction of the evolution of wetland vegetation affected by compound contamination is particularly urgent. We tested the effects of anaerobic iron-rich groundwater discharge in a freshwater marsh by simulating the effect of three levels of eutrophic water on native plants(Glyceria spiculosa(Fr. Schmidt.) Rosh.). The management of wetland vegetation with 1–20 mg/L Fe input is an efficient method to promote the growth of plants, which showed an optimum response under a 0.10 mg/L P surface water environment. Iron-rich groundwater strongly affects the changes in ecological niches of some wetland plant species and the dominant species. In addition, when the P concentration in a natural body of water is too high, the governance effect of eutrophication might not be as expected. Under iron-rich groundwater conditions, the δ~(13)C values of organs were more depleted, which can partially explain the differences in δ~(13)C in the soil profile. Conversely, the carbon isotope composition of soil organic carbon is indicative of past changes in vegetation. The results of our experiments confirm that iron-rich groundwater discharge has the potential to affect vegetation composition through toxicity modification in eutrophic environments.     

基于区域监测站的BDS定轨策略分析

围绕影响轨道精度和实时性的5个要素（模糊度分类固定、测站数量、定轨弧长、太阳光压模型和多系统组合）展开研究,得出区域测站分布下的定轨优选策略。实验表明,选取中国区域27个均匀分布的地面区域监测站,利用72 h弧长观测数据,采用ECOM 5参数简化太阳光压摄动模型、BDS/GPS双系统联合定轨可达到较好的精度,其中GEO卫星轨道精度约291 cm,IGSO/MEO卫星轨道精度优于11 cm。若BDS单系统采用上述策略进行定轨,也可达到GEO卫星299 cm和IGSO/MEO卫星14.4 cm的近似等价定轨精度。