In this age of modern biology, aquatic toxicological research has pursued mechanisms of action of toxicants. This has provided potential tools for ecotoxicologic investigations. However, problems of biocomplexity and issues at higher levels of biological organization remain a challenge. In the 1980s and 1990s and continuing to a lesser extent today, organisms residing in highly contaminated field sites or exposed in the laboratory to calibrated concentrations of individual compounds were carefully analyzed for their responses to priority pollutants. Correlation of biochemical and structural analyses in cultured cells and tissues, as well as the in vivo exposures led to the production and application of biomarkers of exposure and effect and to our awareness of genotoxicity and its chronic manifestations, such as neoplasms, in wild fishes. To gain acceptance of these findings in the greater environmental toxicology community, “validation of the model” versus other, better-established often rodent models, was necessary and became a major focus. Resultant biomarkers were applied to heavily contaminated and reference field sites as part of effects assessment and with investigations following large-scale disasters such as oil spills or industrial accidents.
Over the past 15 years, in the laboratory, small aquarium fish models such as medaka (Oryzias latipes), zebrafish (Danio rerio), platyfish (Xiphophorus species), fathead minnow (Pimephales promelas), and sheepshead minnow (Cyprinodon variegatus) were increasingly used establishing mechanisms of toxicants. Today, the same organisms provide reliable information at higher levels of biological organization relevant to ecotoxicology. We review studies resolving mechanisms of toxicity and discuss ways to address biocomplexity, mixtures of contaminants, and the need to relate individual level responses to populations and communities. 相似文献
The kinetics of cation disordering in a natural ordered (P2/n) omphacite have been followed at P=18 and 30 kb, T= 750–1,260° C, for times of between 1.5 min and 16 days in a piston-cylinder apparatus. Time-temperature-transformation (TTT) analysis of the experimental data, using the presence or absence of the 11¯1 reflection in single crystal X-ray precession photographs to indicate the extent of reaction, yields an equilibrium order/disorder temperature (Tord) of 865±10° C, an activation enthalpy (1 bar) of 71±6 kcal mole–1 and an activation volume of 9±4 cm3 mole–1 (plus and minus figures represent the precision of a best fit between experimental data and TTT theory rather than absolute errors). The activation volume is consistent with a vacancy mechanism of cation diffusion. H2O, added in the form of oxalic acid, appears to speed the process up slightly. The overall transformation mechanism is continuous, involving neither the nucleation of a disordered phase nor a change in antiphase-domain distribution. This is consistent with both first- and non-first-order character for the C2/cP2/n transformation, though a range of ordered states below Tord is indicated by the weakening of h+k=odd reflections. A simple extrapolation of the disordering rates to geological conditions leads to the first estimate of how long disordered omphacites would take to order in nature, ranging from less than one year at T800° C to more than 107 years at T<350° C. 相似文献
California Governor’s Executive Order (CGEO) S-3-05 requires that California greenhouse gas (GHG) emissions be reduced to 80 % below 1990 levels by the year 2050. Meeting this target will require drastic changes in transportation technology, fuel, and behavior which will reduce criteria pollutant emissions as well as GHG emissions. The improvement to local air quality caused by the reduced criteria pollutant emissions must be calculated to fully evaluate the overall benefits and costs of CGEO S-3-05. In the present study, seven different transportation scenarios that move towards the goals of CGEO S-3-05 in the transportation sector were examined to determine how they would affect future airborne particulate matter (PM2.5) concentrations in California: (1) hydrogen fuel cells, (2) electric vehicles, (3) high efficiency vehicles, (4) public mass transit, (5) biofuels, (6) biofuels + hybrid electric vehicles, and (7) hydrogen fuel cells + electric vehicles. The air quality implications of each scenario were evaluated using a chemical transport model applied during a wintertime stagnation episode representing future climate in California. Scenarios (6) and (7) reduced population-weighted PM2.5 mass concentrations by ~9 % and PM2.5 elemental carbon (EC) concentrations by ~30 % relative to base-case predictions. 相似文献
The Newberry Volcano EGS Demonstration in central Oregon tests recent technological advances designed to reduce the cost of power generated by EGS in a hot, dry well (NWG 55-29) drilled in 2008. An EGS reservoir was created by injecting large volumes of cold water, causing existing fractures to slip in shear (known as hydroshearing) generating the seismic waves that can be used to map fracture location and size. At the Newberry Demonstration the final injectivity ranged between 1.4 and 1.7 L/s/MPa a ~6x improvement over the initial injectivity of the well. The injectivity improvement and seismic analysis indicate that previously impermeable fractures were enhanced during the NWG 55-29 stimulation. 相似文献
There has been increasing concern about the lack of involvement by social scientists and humanists in a global change program,
although many social scientists are already directly involved in various aspects of research on environmental change, and
their research interests are clearly central to a global change research agenda. Based on a historical review, the role of
social science disciplines as well as social science institutes in an emerging multidecadal global change program is discussed.
Both “plan of action” and “plan of inaction” are suggested to avoid potential pitfalls due to the rush development of a social
science program into the existing global climate change problem. 相似文献
Bridge scour modeling requires storm surge hydrographs as open ocean boundary conditions for coastal waters surrounding tidal inlets. These open coast storm surge hydrographs are used to accurately determine both horizontal and vertical circulation patterns, and thus scour, within the inlet and bay for an extreme event. At present, very little information is available on the effect that tidal inlets have on these open coast storm surge hydrographs. Furthermore, current modeling practice enforces a single design hydrograph along the open coast boundary for bridge scour models. This study expands on these concepts and provides a more fundamental understanding on both of these modeling areas. 相似文献