壳聚糖在药物缓释中的研究进展

壳聚糖也称甲壳胺或几丁聚糖壳聚糖,是一种天然聚阳离子碱性多糖,其化学名称为(1,4)-2-氨基-2-脱氧-β-D-葡聚糖,是甲壳素脱乙酰基的产物,而甲壳素是虾、蟹等甲壳动物外壳的主要成分,广泛存在于自然界。壳聚糖具有很好的生物相容性和生物可降解性,且其降解产物对人体健康无害,近年来在药物制剂中的应用越来越广泛,作者就壳聚糖在药物缓释、控释中的应用研究进展作一综述。1壳聚糖的药理作用1.1壳聚糖的药理特性壳聚糖及其衍生物是来源于海洋的天然高分子化合物,是天然的动物性食物纤维,是自然界存在的惟一一种碱性多糖,壳聚糖的基本结构单…     

基于无人机高光谱遥感技术对内陆养殖池塘水质监测的研究

为准确、快速、全面获取内陆养殖小区池塘及尾水处理池水体水质变化情况,建立养殖水环境实时预警调控及数字化管控机制,选择浙江湖州市集中连片的养殖小区为试验区,于2020年12月采用搭载GaiaSky-mini高光谱相机的无人机进行试验区近地遥感图像采集,并进行图像拼接、辐射校正和几何校正等预处理;然后对反射波段进行差值、比...     

基于“课程思政”的地理议题式教学设计研究——以“探究青藏高原的形成”为例

思政教育是德育工作的主渠道,围绕立德树人的教育目标,在地理议题式教学开放的环境中进行合作探究,把学生的思政教育融于教学内容,在探究活动的体验与感悟中,做到学用贯通、知行统一,在辩证与分析的过程中锤炼理性思维、培养有责任担当的优秀品质。     

Shell model representation as a substitute of LoD3 for 3D modeling in CityGML

The OGC standard for 3D city modeling is widely used in an increasing number of applications.It defines five consecutive Levels of Detail(LoD0 to LoD4 with increasing accuracy and structural complexity),in which LoD3 includes all exterior appearances and geometrical details and subsequently requires much storage space.A new LoD is introduced as shell model with the exterior shell of the LoD3 model and the opening objects like windows,doors as well as smaller faade objects are projected onto walls.In this paper,a user survey is presented.The results of this survey show that the shell model can give users almost the same visual impression as the LoD3 model.Furthermroe,algorithms are developed to extract the shell model from LoD3 model.Experiments show that this shell model can reduce up to 90% storage of the original LoD3 model.Therefore,on one hand it can be used as a substitute for a LoD3 model for the visualization on small displays.On the other hand,it can be treated as a sub-level of detail(SLoD3) in CityGML,since it retains almost the same amount of information but requires much less storage space.     

小兴安岭-张广才岭地区晚古生代至中生代花岗岩的成因及其地质意义

中国东北地区显生宙花岗岩的成因一直是中亚造山带东段研究的热点之一,尤其是小兴安岭-张广才岭地区的花岗岩其成因及形成的大地构造背景一直存在较大争议。本文新获得小兴安岭-张广才岭铁力和依兰地区的二长花岗岩LA-ICP-MS锆石U-Pb年龄分别为188±1 Ma和257±3 Ma。地球化学数据显示,两地区的二长花岗岩均为Ⅰ型花岗岩并且富集大离子亲石元素(Th和U等)和轻稀土元素,亏损高场强元素(Nb和Ta等)和重稀土元素具有弧岩浆岩的地球化学特征。锆石Hf同位素数据显示,铁力地区二长花岗岩的岩浆源区可能来自于中新元古代的下地壳部分熔融。综合前人在小兴安岭-张广才岭地区已发表的花岗岩类岩石的地质年代学和地球化学数据,初步推测小兴安岭-张广才岭地区在晚古生代至中生代期间处于活动大陆边缘环境。同时,小兴安岭-张广才岭地区晚古生代至中生代的岩浆岩具有自东向西形成时代逐渐变年轻的趋势,这可能是由于东侧的牡丹江洋在晚古生代至中生代期间俯冲角度逐渐变缓造成的。     

古吉黑造山带拼接带地球物理特征线

吉黑造山带拼接带的地球物理特征线，在重磁图上为伊通-吉昌-桦甸、贤儒-安图-开山屯一线。它分割了两种截然不同的地球物理场区，与两侧中元古宙-早三叠世不同的地质发育历史相呼应；和石炭-二叠系安哥拉与华夏植物地球区系的界线相一致。这是有别于前人而为更多新的地质资料所支持的新认识。     

唐山市农业洪涝灾害面积与暴雨关系分析

利用唐山市统计局1985—2014年各县逐年播种面积和农业洪涝受灾面积数据资料、唐山地区11个县市气象站逐日降水资料,采用趋势分析、多项式统计回归等方法,对唐山地区农业洪涝灾害时空特征及与暴雨的关系进行分析。结果表明：唐山洪灾面积总体呈微弱的下降趋势,但不显著,与年暴雨日数变化趋势一致。各县域的洪灾以轻到中度为主,占洪灾的80%—100%。唐山地区洪灾与年暴雨量有关（R = 0.78）,但不显著,受灾面积与年暴雨日数显著相关（R = 0.83,P < 0.01）。中等以上洪灾年的暴雨平均暴雨日数为4—6 d、80%县站大暴雨日数为0.7—1.5 d、60%暴雨累积量在300 mm以上。区域种植结构、地形地势、水系河流分布等因素也是导致洪灾的一个重要方面。     

肋木植物在湖南的发现及其意文

肋木是欧亚大陆早一中三叠世最标志的一属植物,在华南以往的地质文献中尚未报道过。本文描述了首次发现于桑植县一带中三叠世巴东组下段的一种肋木化石即湖南肋木(新种)。根据这个种的孢子囊近似凹入的盘形等特征,认为它是一种适应在水体中漂浮的滨海潮坪植物。此外,文中对肋木的地质、地理分布也作了较系统的总结,并提出其确切的地质时限为印度期一安尼期的看法。     

Mineralogical and geochemical investigations of the Dajia Salento-type bauxite deposits,western Guangxi,China

The Dajia Salento-type bauxite deposit in western Guangxi is hosted within the Quaternary ferrallitic soil profile, and it formed via breaking up, weathering and oxidizing of Permian bauxite orebodies occurring as a semi-continuous layer in the upper Permian. Mineralogical analyses reveal that diaspore, hematite and kaolinite are the major minerals in bauxite ores with small amounts of anatase, chamosite, gibbsite, goethite, illite, zircon, quartz and pyrite. The ore texture and mineral assemblage reveal that the depositional/diagenetic environment of the Dajia bauxite was much close to phreatic environment. Both the ore texture and the morphology of zircon grains also indicate that most of the bauxitic soils were transported a short distance. Diaspore is suggested to be non-metamorphic in origin and mainly formed in a reducing condition of diagenetic environment, while kaolinite is the product of the in situ epigenetic replacement of alumina in diaspore by dissolved silica. Geochemical analyses indicate that Al₂O₃, Fe₂O₃, SiO₂ and TiO₂ are the main components of the bauxite ores and trace elements such as Zr, Hf, Nb, Ta, Th and U were enriched during the bauxitization process. Simultaneously, Zr vs. Hf and Nb vs. Ta show a high correlation. Geochemical indices such as Zr/Hf, Nb/Ta and Eu/Eu* (among others) denote that the magmatic rocks related to the Emeishan plume in western Guangxi and the carbonates in the underlying Maokou Formation provided the main sources of material for the bauxite ores.