Environmental Copper and Manganese in the Pathophysiology of Neurologic Diseases (Alzheimer's Disease and Manganism)

Alzheimer's disease (AD) is the most common form of dementia. Populations migrating from developing to industrialized countries seem to elicit a higher incidence and prevalence rate of AD, suggesting lifestyle and environmental factors to have a role in the pathophysiology of AD. One of its major neuropathological hallmarks is the deposition of Aβ peptides as amyloid plaques in the brain of AD patients. Aβ is proteolytically cleaved out of the larger amyloid precursor protein (APP). Cu and Mn are often found in drinking water and may have a neurotoxic potential. APP is involved in Cu homeostasis in mouse and man. In vitro observations and in vivo data obtained from APP mouse models provide strong evidence that APP overexpression enables intracellular Cu to be transported out of the cell. Disturbed metal‐ion homeostasis with elevated serum Cu levels occurs in Alzheimer and Down's patients and lowered levels in post‐mortem AD brain. We observed that bioavailable Cu has specific beneficial effects in an Alzheimer's disease mouse model. This should be regarded as a proof‐of‐concept for a prophylactic approach to overcome the observed CNS Cu deficiency in the brain of Alzheimer's disease patients. Manganism is a disorder with symptoms similar to that of Parkinson's disease. The precise mechanism how manganese can damage the nervous system is unknown. There is some evidence that iron and manganese may utilize similar transport systems. Epidemi ologic data strongly suggests that manganese enters the body primarily via inhalation and through the ingestion of manganese in drinking water.     

The Glueckstadt Graben, a sedimentary record between the North and Baltic Sea in north Central Europe

The Glueckstadt Graben is one of the deepest post-Permian structures within the Central European Basin system and is located right at its “heart” at the transition from the North Sea to the Baltic Sea and from the Lower Saxony Basin to the Rynkoebing–Fyn High.The Mesozoic to recent evolution is investigated by use of selected seismic lines, seismic flattening and a 3D structural model. A major tectonic event in the latest Middle–Late Triassic (Keuper) was accompanied by strong salt tectonics within the Glueckstadt Graben. At that time, a rapid subsidence took place within the central part, which provides the “core” of the Glueckstadt Graben. The post-Triassic tectonic evolution of the area does not follow the typical scheme of thermal subsidence. In contrast, it seems that there is a slow progressive activation of salt movements triggered by the initial Triassic event. Starting with the Jurassic, the subsidence centre partitioned into two parts located adjacent to the Triassic “core.” In comparison with other areas of the Central European Basin system, the Glueckstadt Graben was not strongly affected by additional Jurassic and Cretaceous events. During the late Jurassic to Early Cretaceous, the area around the Glueckstadt Graben was affected by relative uplift with regional erosion of the elevated relief. However, subsidence was reactivated and accelerated during the Cenozoic when a strong subsidence centre developed in the North Sea. During Paleogene and Quaternary–Neogene, the two centres of sedimentation moved gradually towards the flanks of the basin.The data indeed point toward a control of post-Permian evolution by gradual withdrawal of salt triggered by the initial exhaustion along the Triassic subsidence centre. In this sense, the Glueckstadt Graben was formed at least partially as “basin scale rim syncline” during post-Permian times. The present day Hamburger, East and Westholstein Troughs are the actual final state of this long-term process which still may continue and may play a role in terms of young processes and, e.g., for coastal protection.     

Structure and evolution of the Glueckstadt Graben due to salt movements

The salt tectonics of the Glueckstadt Graben has been investigated in relation to major tectonic events within the basin. The lithologic features of salt sections from Rotliegend, Zechstein and Keuper show that almost pure salt is prominent in the Zechstein, dominating diapiric movements that have influenced the regional evolution of the Glueckstadt Graben. Three main phases of growth of the salt structures have been identified from the analysis of the seismic pattern. The strongest salt movements occurred at the beginning of the Keuper when the area was affected by extension. This activation of salt tectonics was followed by a Jurassic extensional event in the Pompeckj Block and Lower Saxony Basin and possibly in the Glueckstadt Graben. The Paleogene–Neogene tectonic event caused significant growth and amplification of the salt structures mainly at the margins of the basin. This event was extensional with a possible horizontal component of the tectonic movements. 3D modelling shows that the distribution of the initial thickness of the Permian salt controls the structural style of the basin, regionally. Where salt was thick, salt diapirs and walls formed and where salt was relatively thin, simple salt pillows and shallow anticlines developed.     

On results of the surface wave analyses in poroelastic media by means of the Simple Mixture Model and the Biot model

This note is devoted to an overview of the results on the number, velocity and attenuation of surface waves in two-component saturated poroelastic media. The author's numerical results which have been obtained using the Simple Mixture Model are compared to some results of other authors who carried out either an analysis by means of the classical Biot model for poroelastic media or experiments. It is shown that the Simple Mixture Model is a simplification of the Biot model. Due to its simpler form the Simple Mixture Model is more suitable for a complex analysis which depends on several parameters. Thus, the Simple Mixture Model is the only model for which, simultaneously, either the dependence on the frequency, ω, and the dependence on the bulk permeability, π (boundary porous medium/vacuum) or the dependence on the frequency, ω, and the dependence on the surface permeability, α (boundary porous medium/fluid) has been considered.     

Hydrothermal gases offshore Milos Island, Greece

Hydrothermal fluids emerge from the seafloor of Paleohori Bay on Milos. The gases in these fluids contain mostly CO₂ but CH₄ concentrations up to 2% are present. The stable carbon isotopic composition of the CO₂ (near 0%) indicates an inorganic carbon source (dissociation of underlying marine carbonates). The carbon and hydrogen isotopes of most CH₄ samples are enriched in the heavy species (δ¹³C = −9.4 to −17.8‰; δD = −102 to −189‰) which is believed to be characteristic for an abiogenic production of CH₄ by CO₂-reduction (Fischer-Tropsch reactions). Depletions in the deuterium content of three CH₄ samples (to −377%) are probably caused by unknown subsurface rock alteration processes. Secondary hydrogen isotope exchange processes between methane, hydrogen and water are most likely responsible for calculated unrealistic methane formation temperatures.

We show that excess helium, slightly enriched in ³He, is present in the hydrothermal fluids emerging the seafloor of Paleohori Bay. When the isotopic ratio of the excess component is calculated a ³He/⁴He_excess of 3.6 · 10⁻⁶ is obtained: This indicates that the excess component consists of about one third of mantle helium and two thirds of radiogenic helium. We infer that the mantle-derived component has been strongly diluted by radiogenic helium during the ascent of the fluids to the surface.     

Chronometric calibration of a comparative time scale for the mesozoic and paleozoic

The relationship between radiometric and biostratigraphic ages is analyzed by local empirical methods and illustrated in chronograms for the mesozoic and paleozoic stages. The chronograms allow estimates for stage boundaries and their errors. Consequently, the ages for epoch boundaries and their errors are discussed which, for several reasons, may not be identical with the age and error of the oldest stage of an epoch.The analysis results in a comparative time scale which could be a compromise between the time scales currently under discussion. A specific feature of the derived time scale is its rather strong cyclicity with periods around 74 (73±1) ma.

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Zusammenfassung Alter und Fehlergrenzen für mesozoische und paläozoische Stufengrenzen werden mittels einer lokalen empirischen Schätzmethode neu berechnet. Daraus ergeben sich Schätzungen für die Alter und Fehler der Epochengrenzen, die aus verschiedenen Gründen nicht mit denen derältesten Stufe einer Epoche zusammenfallen.Die Auswertung der Chronogramme führt zu einer vergleichenden Zeitskala, die im wesentlichen einen Kompromi\ zwischen den gegenwärtig gängigen Zeitskalen darstellt. Bemerkenswert ist, da\ die Zeitskala ein hohes Ma\ an Zyklizität aufweist, wobei sich Perioden von 74 (73±1) ma ergeben.

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Résumé Les relations entre les âges radiométriques et les âges biostratigraphiques sont analysées par des méthodes locales et empiriques. Elles sont présentées dans des chronogrammes se référant aux étages du MésozoÏque et du PaléozoÏque. Ces chronogrammes permettent d'estimer les limites d'étages et les erreurs de cette estimation. Les âges des limites de systèmes et leurs erreurs sont discutés en conséquence. Pour diverses raisons ils ne sont pas identiques à ceux de l'étage le plus ancien d'un système.L'analyse des chronogrammes aboutit à une échelle de temps comparative qui représente un compromis entre les échelles de temps couramment discutées. Une propriété remarquable de cette échelle est de faire apparaÎtre une cyclicité dont la période est de 74 (73±1) Ma.

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Sediment compaction in large scale systems

The classical partial differential equation for compaction proves to provide a rather singular model, if the deformations caused by overload become reasonably large. An alternative model for compaction is derived by adapting an Eulerian view and by deriving the model equations from integral equations rather than from a priori differentiability assumptions. The result is not — as usual — a single partial differential equation, but an infinite set of differential equations, interesting in both mathematical and geological terms.Although there are still several simplifications and linearizations in the derived model, the model illustrates at least that the classical Terzaghi equation and mathematical models in its vicinity are highly idealized and probably instable, if applied to large scale systems.

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Zusammenfassung Die klassische partielle Differentialgleichung für die Kompaktion stellt ein sehr vereinfachtes Modell dar, zumindest für den Fall, daß die Deformationen infolge Auflast sehr groß werden. Hier wird ein alternatives Modell entwickelt, das nicht von der Voraussetzung der Differenzierbarkeit ausgeht, sondern über Integralgleichungen entwickelt wird, wobei die Eulersche Sicht des Raum-Zeitbezuges zur Anwendung kommt. Das Resultat ist dann nicht mehr eine einfache partielle Differentialgleichung, sondern ein unendliches System solcher Gleichungen.Obwohl auch das entwickelte Modell vereinfachte Annahmen erfordert und stark linearisiert, so verdeutlicht es doch zumindest, daß die klassische Therzaghi Gleichung und modifizierte Modelle, die auf diese Gleichung aufbauen, sehr wahrscheinlich instabil sind, wenn sie auf Systeme mit großen Deformationen angewandt werden.

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Résumé L'équation classique aux dérivées partielles de la compaction fournit un modèle très simplifié, particulièrement dans le cas où les déformations dues à la surcharge deviennent considérables. L'auteur propose en alternative un modèle, adapté des conceptions eulériennes, qui repose sur les équations intégrales plutót que sur la présomption de différenciabilité. Le résultat n'est plus une simple équation aux dérivées partielles, mais un système infini de telles équations.Bien que le modèle présenté implique des hypothèses simplificatrices et des linéarisations, on peut néanmoins en déduire que l'équation classique de Terzaghi, ainsi que les modèles modifiés qui en découlent, sont très probablement instables s'ils sont appliqués à des systèmes à forte déformation.

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