Antiangiogenic activity of low-temperature lysozyme from a marine bacterium <Emphasis Type="Italic">in vivo</Emphasis> and <Emphasis Type="Italic">in vitro</Emphasis>

We extracted marine low-temperature lysozyme (MLTL), a novel lysozyme, from a marine microorganism through fermentation. Our previous study suggested that a low molecular weight (16 kDa) may exert anti-tumor activity through antiangiogenesis. In this study, we extracted a high weight (39 kDa) and investigated its antiangiogenic activity in vivo and in vitro. Using zebrafish embryos as an in vivo study model, we found that treatment with MLTL significantly inhibited the growth of subintestinal vessels (SIVs) in a dose-dependent manner and that 400 μg/ml MLTL was sufficient to block the growth of SIVs. An in vitro study conducted using human umbilical vein endothelial cells (HUVECs) revealed that MLTL suppressed the proliferation, migration and tube formation of HUVECs in a dose-dependent manner. Interestingly, assays by flow cytometry and DNA electrophoresis indicated that MLTL was able to induce apoptosis of HUVECs. Moreover, further study demonstrated that the disruption of intracellular Ca²⁺ homeostasis may play an important role in MLTL induced apoptosis of HUVECs. Taken together, the results of this study demonstrate for the first time that MLTL inhibits angiogenesis through its pleiotropic effects on vascular endothelial cells and induces apoptosis through regulation of cellular Ca²⁺ levels. The results of this study also revealed a possible mechanism underlying the antiangiogenic effect of MLTL and suggested that MLTL may be a promising new antiangiogenic agent for use in cancer therapy.     

壤中气汞测量在活断层研究中的应用

利用JM—3型数字金膜测汞仪对渭河盆地活动断层进行壤中气汞测量,取得了初步结果。认为,壤中气汞异常与活动断层存在着密切的关系,通过测汞寻找隐伏活动断层,判定断层活动性是可行的。     

Ekman motion in shallow open sea in the presence of time-harmonic variation of water depth

The time variation of the wind-induced flow in a homogeneous unbounded sea region has been analytically investigated. The time-dependent Ekman solution in a homogeneous, shallow open sea has been further extended by taking into account the time variation in water depth which might be caused by either tidal motion or change in the mixed layer thickness. The solution approach taken in this study is based on the Galerkin-eigenfunction method originally developed by Heaps [1972. On the numerical solution of three-dimensional hydrodynamical equations for tides and storm surges. Memoires de la Societe Royale des Sciences de Liege Serie 6(2), 143–180]. A series of calculations have been made with emphasis on the influence of the time variation in water depth upon the build-up of Ekman spirals in the presence of oscillatory variations in water depth. It has been found that two oscillations contribute to the wind drift current, the inertial oscillation and the depth-variation-induced oscillation; the inertial oscillation decays with time, but the depth-variation-induced oscillation remains undamped despite the presence of bottom friction. The presence of time-harmonic variation produces peculiar forms of hodograph with a curled or circular pattern according to the angular frequency of the water depth variation.     

3D裂隙网络随机模拟及其工程应用研究

岩体中存在的大量随机分布的裂隙对岩体的工程性质及稳定性有着极其重要的影响。传统的工程地质研究方法难以客观地描述其空间分布特征。应用概率与统计学的理论 ,通过统计分析得到裂隙的分布规律性 ,采用随机模拟的方法实现与统计分布相适应的裂隙网络是研究随机裂隙宏观特征的有效途径。通过模拟所得的 3D裂隙网络 ,进一步研究了裂隙的连通特征及工程开挖面上的稳定分析与加固措施优化的方法     

动态数据交换在车载GPS导航系统中的应用

叙述了Windows应用程序之间进行数据交换的一种方式－动态数据交换的一些基本概念、基本思想和交换的过程。通过车载GPS导航系统实验，证明了当两个不同的应用系统之间要求动态地实时传输数据时，DDE是一种很好的途径。     

Secondary dispersion from gold deposits in west Turkey

Orientation studies over the Sarpda? prospect in the Biga peninsula and the Arapdagi deposit near Izmir have provided elear evidence for elemental dispersion around west Turkish gold prospects. Although these deposits are of different types, silicification associated with the deposits results in the main part of both deposits forming topographic highs.At Sarpda? gold mineralisation is relatively weak compared with nearby prospects and associated with a silicified cap on the main hill. Comparison of coarse and fine fractions, based on a 190 μm size split of 8 kg of -2 mm material, suggests that gold disperses clastically on the steep slopes, probably within silica, but coarse grains break down giving Au concentrations in the finer fractions at the base of the main slope. Discrete gold grains, that can be panned, only occur 1–2 km downstream within the streams and heavy mineral concentrations are very limited. This interpretation of Au dispersion is consistent with the data from 1 kg samples collected at the higher primary grade, but more contaminated, Arapda?i prospect.Antimony is the most consistent pathfinder both for the silicified cap at Sarpda? and for gold-rich veins at Arpada?i. It gives high contrast anomalies. Arsenic is useful being more mobile than Sb, although contrast may be low. High resolution Ag data can be useful but base metal enrichments are also often associated with Ag anomalies. Most prospects have some base metal enrichments although they can be displaced from the main gold-rich parts of the deposit and anomalies may be weak. Lead and Cu are the more consistently useful elements.The use of large (> 8 kg of -2 mm material) samples produces consistent stream sediment data that can be used to reliably interpret single samples and quantify Au anomalies. A survey around the Halíköy Hg and Emirli Sb mines, using these large samples, confirmed the extension of the known gold-bearing Emirli structure. In contrast the major Hg-bearing Halíköy Fault is gold poor although a structure parallel to it is auriferous.     

对于氟碳钡铈矿（Cordylite—Ce）成分与结构的质疑

本文讨论了氟碳钡铈矿的成分和结构问题。发现氟碳钡铈矿的成分、密度、折射率三者间的一致性参数很差,晶体结构与光性和空间群相矛盾,单个大阳离子的平均占有体积远大于同类矿物的平均占有体积,它的晶体结构与同类矿物不可类比。由于受当时条件的限制,在以往有关氟碳钡铈矿的成分和结构的资料中存在着一些明显的错误,有必要对其进行重新定义。其结构化学式应改为:(Na_(1-x),Ca_(0·5x))BaCe_2(CO_3)_4F。     

用气象卫星资料监测冬麦长势和估测产量的研究

利用１９９２、１９９３年的气象卫星资料，分析植被指数与甘肃省冬麦区３３个县市冬麦产量的关系，发现绿峰植被指数与产量存在极好的相关性。另外，从预测产量的角度和预报时限要求出发，可用４月中下旬累积植被指数预测冬麦产量，并给出了预报方程。     

黑龙江伊春红山华夏—安加拉混生植物群

系统研究了黑龙江省伊春红山地区晚二叠世红山组植物群,认为其性质为华夏—安加拉混生植物群。华夏植物区与安加拉植物区的界限,应以内蒙古陆及其东、西延展部分为界。