Effects of sulfate chitosan derivatives on nonalcoholic fatty liver disease

Sulfate chitosan derivatives have good solubility and therapeutic effect on the cell model of NAFLD. The aim of this study was to examine the therapeutic effect of sulfate chitosan derivatives on NAFLD. The male Wistar rats were orally fed high fat emulsion and received sulfate chitosan derivatives for 5 weeks to determine the pre-treatment effect of sulfate chitosan derivatives on NAFLD. To evaluate the therapeutic effect of sulfate chitosan derivatives on NAFLD, the rats were orally fed with high concentration emulsion for 5 weeks, followed by sulfate chitosan derivatives for 3 weeks. Histological analysis and biomedical assays showed that sulfate chitosan derivatives can dramatically prevent the development of hepatic steatosis in hepatocyte cells. In animal studies, pre-treatment and treatment with sulfate chitosan derivatives significantly protected against hepatic steatohepatitis induced by high fat diet according to histological analysis. Furthermore, increased TC, ALT, MDA, and LEP in NAFLD were significantly ameliorated by pre-treatment and treatment with sulfate chitosan derivatives. Furthermore, increased TG, AST, and TNF-α in NAFLD were significantly ameliorated by treatment with sulfate chitosan derivatives. Sulfate chitosan derivatives have good pre-treatment and therapeutic effect on NAFLD.     

Laboratory Investigation into the Evaporation of Natural-Gas Condensate Oils: Hints for the Sanchi Oil Spill

The Sanchi oil tanker collision in the East China Sea on January 6th, 2018 has caused worldwide attention due to its uniqueness. A considerable amount of h     

中国沿海海洋站GNSS坐标时间序列噪声模型的建立与分析

选取中国沿海海洋站中与验潮室并址的22个GNSS基准站近9 a的观测资料,利用最大似然估计法分析各站时间序列的噪声特性,建立最优噪声模型;然后顾及有色噪声,利用最优噪声模型估计测站速度,并与纯白噪声模型和GLOBK获取的速度及误差进行对比分析。结果表明：1）沿海海洋站的GNSS时间序列均含有有色噪声,各分量的噪声特性不完全一致,E方向和U分量均以白噪声+闪烁噪声为主,N分量以白噪声+闪烁噪声和白噪声+一阶马尔科夫噪声+随机漫步噪声为主。2）全国沿海3个海区N、E分量的白噪声和闪烁噪声基本呈现越往南噪声越大的规律,南海海区U分量的白噪声和闪烁噪声最大。3）顾及有色噪声的速度中误差是仅考虑白噪声和GLOBK估计的速度中误差估计值的5～10倍,这种差异比内陆观测站的要大。4）在对海洋站GNSS时间序列进行速度分析时,为获取正确的速度值,应该先准确判断噪声的类型,再顾及有色噪声的影响估计测站速度。     

Advanced glycation endproducts in 35 types of seafood products consumed in eastern China

Advanced glycation endproducts(AGEs) have been recognized as hazards in processed foods that can induce chronic diseases such as cardiovascular disease, diabetes, and diabetic nephropathy. In this study, we investigated the AGEs contents of 35 types of industrial seafood products that are consumed frequently in eastern China. Total fluorescent AGEs level and Nε-carboxymethyl-lysine(CML) content were evaluated by fluorescence spectrophotometry and gas chromatography-mass spectrometry(GC-MS), respectively. The level of total fluorescent AGEs in seafood samples ranged from 39.37 to 1178.3 AU, and was higher in canned and packaged instant aquatic products that were processed at high temperatures. The CML content in seafood samples ranged from 44.8 to 439.1 mg per kg dried sample, and was higher in roasted seafood samples. The total fluorescent AGEs and CML content increased when seafood underwent high-temperature processing, but did not show an obvious correlation. The present study suggested that commonly consumed seafood contains different levels of AGEs, and the seafood processed at high temperatures always displays a high level of either AGEs or CML.     

山东省矿产资源开发利用现状与保护对策探讨

山东是矿业大省,矿产资源的开发程度较高,但也存在着不容忽视的问题。针对产生这些问题的原因,提出了实现矿产资源可持续开发利用的六项建议,强调应从增强矿产资源的忧患意识、保护生态环境、加强矿产勘查、强化政府管理职能及依靠科技进步等方面加大工作力度。     

攀枝花太阳能资源评价

为了有效地开发和利用攀枝花太阳能资源,本文在广泛搜集国内相关地区太阳辐射资料的基础上,整理了攀枝花几十年的太阳能相关气象数据,通过天文辐射量、日照百分率、经纬度、水汽压等因子建立相关辐射量计算模式,系统地分析和研究了攀枝花地区太阳能辐射量的主要分布特征和优势,对大力开发利用攀枝花太阳能资源提供了科学依据,并就如何发展特色农业和旅游业等综合开发利用方面提出了具体可行的对策建议。      

莒县长岭镇整合矿产资源促进矿业经济可持续发展

日照市莒县长岭镇走规模化、集约化经营之路,使该镇一度陷入低谷的砖瓦产业重新焕发生机,一度外流的投资业户重新归来。截至目前,全镇砖瓦厂已发展到30余处,形成年消耗页岩粘土60万m3,年产砖瓦4.2亿片(块)的生产能力。产品畅销省内外,甚至国外,年产值过亿元,仅此一项税收就占全     

雷电临近预警产品评估方法及其软件

为了适应雷电业务发展的需求,对已经投入业务运行试验的雷电临近预警系统的预警效果做出客观评估,中国气象科学研究院雷电物理和防护工程实验室开展了雷电临近预警产品评估方法的研究,并开发了配套的应用软件.评估方法通过雷电预警结果和实际监测结果的对比,得到命中率POD、虚警率FAR和TS评分三项指标,实现对雷电预警产品的评估.评估软件的实际运行表明:该方法不仅能够检验CAMS_LNWS预报雷电活动的能力,还能对预警方法的改进起到一定的指导作用,能够满足雷电业务产品评估的需要.     

影响靖宇地区温带气旋的统计分析

核电站因它不排放如二氧化碳这样的温室气体,核电对降低能源部门的碳密集作出了贡献,因此愈益受到人们的重视.在对核电站地区的天气、气候环境进行分析的基础上,对影响靖宇核电站地区的温带气旋作了研究.结果表明:1949-2007年期间影响靖宇地区的温带气旋计111个;受温带气旋影响的年数有41年(约2/3).影响靖宇地区且产生强降雨的温带气旋,主要发生在6、7、8月这3个月,并且一半以上出现在7月.影响靖宇地区的温带气旋大部分是东北气旋,占总数的65%;蒙古气旋与华北气旋次之.此外,对造成严重影响的温带气旋的个例也从天气学角度进行了分析.     

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