AbstractThe critical state and steady state theories are widely accepted for simulating the soil behavior and providing a basis for liquefaction evaluation and constitutive modeling. However, there was conflicting evidence regarding the critical state and steady state of sands in the last decades. In some cases, the critical state and steady state are taken to be identical and in others they differ significantly. Whether they are the same or not remain a hot academic debate to date. This paper provides a critical review on the origin and history of the critical state and steady state of sands, which identifies conflicting evidences and discusses the influencing factors on the existence and uniqueness of critical state and steady state. Based on a critical review of literature, it is concluded that the steady state concept is a refinement of the critical state concept and the uniqueness of the critical state and steady state was affirmed. Special care should be paid in the laboratory techniques in order to accurately measure the critical state and steady state due to the numerous influencing factors of them. 相似文献
We demonstrated that an extract from Pylaiella littoralis, collected from the Federate States of Micronesia (FSM), could inhibit the proliferation of tumor cells. P. littoralis extract (PLE) showed anti-proliferative activities in the tumorigenic cells tested, ranging from 20.2% to 67.9%. The highest inhibitory activity, in HT-29 cells, was selected for further experiments. PLE showed no cytotoxic effect in normal cells and inhibited the growth of HT-29 cells depending on concentration and incubation time. PLE-treated HT-29 cells showed the typical morphological characteristics of apoptosis, such as apoptotic body formation and DNA fragmentation. PLE also induced mitochondrial membrane potential depolarization and resulted in increased mitochondrial membrane permeability, compared with untreated cells. PLE decreased Bcl-2 protein and increased Bax protein expression, activating caspase-3 and poly (ADP-ribose) polymerase (PARP) expression via the caspase pathway. PLE also increased the phosphorylation of c-Jun N-terminal kinase (JNK), p38, and extracellular signal-regulated kinase (ERK), and it reduced cell viability in treatment cells with specific inhibitors such as PD98059 (a specific inhibitor of ERK), SP600125 (a specific inbibitor of JNK), and SB 203580 (a specific inbibitor of p38 MAPK). via the the mitogen-activated protein kinases (MAPKs) pathway. These results suggest that PLE inhibits the proliferation of HT-29 cells by affecting the caspase and MAPK pathways involved in the induction of apoptosis. Thus, we suggest that P. littoralis extract might be potential candidate agents for the treatment of human colorectal cancer. 相似文献
Prorocentrum spp. are planktonic and/or benthic species. Benthic Prorocentrum species are of primary concern to scientists and the public because some of them are toxic. We established clonal cultures of 3 strains of Prorocentrum species that were collected from the thalli of a macroalga in the coastal waters off Jeju Island, located at the southern end of Korea. The Korean strains of P. cf. rhathymum, which are morphologically almost identical to the Virgin Island strain of P. rhathymum, were different from P. mexicanum because the former dinoflagellate has one simple collar-like spine in the periflagellar area, while the latter dinoflagellate has a 2- or 3-horned spine. In addition, the sequences of the small subunit (SSU) rDNA of the Korean strains were identical to those of the Malaysian and Floridian strains of P. rhathymum, while the sequences of the large subunit (LSU) rDNA of the Korean strains were 0.1–0.9% different from those of the Iranian and Malaysian strains of P. rhathymum. In phylogenetic trees based on the SSU rDNA sequences, the Korean strains of P. rhathymum formed a clade with the Malaysian and Floridian strains of P. rhathymum and the Vietnamese and Polynesian strains of P. mexicanum. However, in phylogenetic trees based on the LSU rDNA sequences, the Korean strains of P. rhathymum formed a clade with the Iranian strain of P. rhathymum and the Spanish and Mexican strains of P. mexicanum. Therefore, the molecular characterization of the Korean strains does not allow us to clearly classify them as P. rhathymum, nor P. mexicanum, although their morphology has so far been reported to be closer to that of P. rhathymum than P. mexicanum and thus we designated them as P. cf. rhathymum. 相似文献
The devastating MS8.0 Wenchuan earthquake ruptured two large parallel thrust faults along the middle segment of the Longmenshan thrust belt. Preseismic and postseismic leveling data indicated the hanging wall of the YingxiuBeichuan-Nanba thrust fault mainly presented coseismic uplift with respect to the reference point at Pingwu county town, and the observed maximum uplift of 4.7 m is located at Beichuan county (Qushan town) which is about 100 m west of the fault scarp. The foot wall of the Yingxiu-Beichuan-Nanba thrust fault mainly showed subsidence with maximum subsidence of 0.6 m near the rupture. By employing a listric dislocation model, we found that the fault geometry model of exponential dip angle δ= 88°?×1-exp(-9/h) with depth of 18 km and uniform thrust-slip of 5.6 m could fit the observed coseismic vertical deformation very well, which verifies the listric thrust model of the Longmenshan orogenic zone.
Field experiments were conducted on bed load transport in the Diaoga River, a mountain stream in southwest China, to study the variation of bed load transport with varying sediment supply. The rate of bed load transport is greatly affected by incoming sediment (load and size). Under the same flow conditions, bed load transport rates may differ by three orders of magnitude depending on whether measurements were taken before or after the first flood of the year. The relation of the "bed load transport rate versus flow intensity" appears to have similar characteristics as a clockwise looped-rating curve. Experiments also were conducted during the non-flood season to study bed load transport processes with different incoming load from an upstream section. Bed load with different sizes can be grouped into two types: traveling bed load and structural bed load. Traveling bed load is composed of sediment finer than a critical size, De, and its transport rate depends mainly on the incoming sediment rate. The incoming sediment rate can alter the rate of bed load transport by three orders of magnitude. Structural bed load is composed of coarser sediment and its transport rate closely relies on the flow intensity. 相似文献
China’s economic and social development is severely restricted by regional water deficiency, and the determination of water deficiency level in different regions is an important basis of water resource management. In this study, we zoned 32 provinces of China into five surface water deficiency levels based on surface water deficit index derived from the Chinese meteorological satellite FY-2C images. The result shows that China is facing serious water shortage crisis with only 15.44% of total area without water deficiency, which is located in the south and southeast coast. More than 60% of total area of China suffered from severe or extremely water deficiency, which are mainly distributed in western and northern regions. Jingjinji area (namely Beijing, Tianjin and Hebei province), which is a special region with high amount of gross domestic product and relative abundant water resources, is suffering from severe water deficiency. It revealed that water resources were interacted with regional development and water management should consider local conditions. To Jingjinji area, water management should focus on adjustment of industrial structure, urban expansion control and scientific water resources allocation. In general, the surface water deficit index based water deficiency zoning will be of significant value to be applied in water resources management at regional scales. 相似文献