Analysis of mutations in the p53 tumor suppressor gene and Ki- and Ha-ras proto-oncogenes in hepatic tumors of European flounder (Platichthys flesus).

DNA from five tumors, three other-injured livers and two normal liver tissue samples from the European flounder were analyzed for mutations in exons 5-8 of the tumor suppressor gene p53 and at codons 12, 13 and 61 of Ha- and Ki-ras proto-oncogenes. No tumor-specific mutations were identified by direct sequencing and single-strand conformation polymorphism of these genes. A number of silent polymorphisms were noted in p53. In addition to a need for more extensive analyses of flounder liver tumor samples for ras or p53 mutations, other cancer-related genes should be investigated.     

A theoretical model of Fanaroff-Riley I jets

A fluid model of the jets in Fanaroff-Riley I class, for extended extragalactic radio sources, based on the idea that they are turbulent low Mach number supersonic flows consisting of relativistic and nonrelativistic plasma, has been developed. Mean flow approach and modified mixing length theory by Prandtl are used to obtain a corresponding mathematical tool. It is assumed that magnetic field is weak. Boundary conditions concerned the problem of the jet propagation through a non-uniform atmospheres of an elliptical galaxies are considered. Short discussion of the observational data determining the choice of the input parameters of the jets is given.     

Principal Components Analysis of Rainfall and Associated Synoptic Models of the Southwest Monsoon over India

Summary  The summer monsoon circulation shows various spatial and temporal oscillations and often a combination of systems produces an integrated effect. In this study phases of the southwest (SW) monsoon have been identified in an objective manner with the help of T-mode principal component analysis (PCA) of weekly rainfall anomalies. Mean composite charts have been prepared utilising all available upper air data (1977–1986) for each category of the SW monsoon epochs identified by the PCA. These sets of charts have been constructed for both the strong and weak phases associated with the first four significant principal components (PCs). A well defined east-west oriented trough system, extending from about 28° N Latitude/65° E Longitude to 20° N Latitude/90° E Longitude, in the lower levels, has been the main feature associated with the strong phase of the monsoon corresponding to PC I. The trough in the lower levels is more marked in the eastern half compared to the western half in both the sets of charts associated with strong phases of the monsoon related to the PC II and PC III. With PC II, the position of the troughs in the lower levels is further north of its location in PC III. The east-west trough system associated with the strong phase of PC IV has a large southward tilt with height. The charts corresponding to the weak phases of these PCs have synoptic features, such as the position of the trough close to the foothills of the Himalayas, and the shifting of middle and upper tropospheric anticyclones to the south. The study suggests an objective method of interpretation of principal components by utilising synoptic data. In addition, synoptic models and data sets corresponding to different phases of the monsoon can also be prepared in an objective manner by such PCA. Received July 18, 1997 Revised April 30, 1999     

Alteration processes in the CV chondrite parent body based on analysis of NWA 2086 meteorite

Analysis of the NWA 2086 CV3 chondrite showed a matrix/chondrule ratio of 52%, similar to Bali, Mokoia, and Grosanaja. Nearly twice as many chondrule fragments as intact ones demonstrate that an early fragmentation phase occurred prior to final accretion. After this event, no substantial mechanical change or redeposition is evident. Rims with double‐layered structures were identified around some chondrules, which, in at least one case, is attributed to an accretionary origin. The rim's outer parts with a diffuse appearance were formed by in situ chemical alteration. During this later process, Mg content decreased, Fe content increased, and olivine composition was homogenized, producing a rim composition close to that of the matrix. This alteration occasionally happened along fractures and at confined locations, and was probably produced by fluid interactions. Iron oxides are the best candidate for a small grain‐sized alteration product; however, technical limitations in the available equipment did not allow exact phase identification. These results suggest that NWA 2086 came from a location (possible more deeply buried) in the CV parent body than Mokoia or Bali, and suffered less impact effects—although there is no evidence of sustained thermal alteration. This meteorite may represent a sample of the CV parent asteroid interior and provide a useful basis for comparison with other CV meteorites in the future.     

The evolution of regional development concepts: some new trends

This paper traces the theoretical development of the regional concept and the use of regionalization techniques in Soviet geography and seeks to compare this history with comparable trends in Western geography. It is severely critical of the major and rapid paradigm shifts noticed in post-war Western geographical science and relates these to shifts in the approach to global development issues.     

VERTICAL SEISMIC PROFILING IN COAL*

The intellection of seismic wave propagation in coal measures demands direct observation of the wavefield progression. Two vertical seismic profiles with high spatial and temporal sampling, were recently recorded in the Sydney Basin coalfields as part of an experimental coal seismic program. Static corrections and interval velocities were obtained by an automated system to determine first kicks and pulse rise times. Upgoing and downgoing waves were separated in the f—k-plane using a novel technique of contour slice filtering. The isolated upgoing waves clearly display reflections from the major coal seams within the stratigraphic sequence. The downgoing wave spectra were subjected to attenuation analysis. The deduced specific quality factor Q for Permian coal measure rocks lies in the range 20–70. Similar estimates were obtained in the time domain from measurements of pulse broadening. Synthetic VSP seismograms, computed using an exact recursive formulation, are an indispensable aid to interpretation. They illustrate the filtering effects of coal seams and sequences, and the effects of the contribution of internal and free-surface multiple reflections in the recorded wavetrains.     

Short gamma-ray bursts from SGR giant flares and neutron star mergers: two populations are better than one

There is increasing evidence of a local population of short duration gamma-ray bursts (sGRB), but it remains to be seen whether this is a separate population to higher redshift bursts. Here we choose plausible luminosity functions (LFs) for both neutron star binary mergers and giant flares from soft gamma repeaters (SGR), and combined with theoretical and observed Galactic intrinsic rates we examine whether a single progenitor model can reproduce both the overall Burst and Transient Source Experiment (BATSE) sGRB number counts and a local population, or whether a dual progenitor population is required. Though there are large uncertainties in the intrinsic rates, we find that at least a bimodal LF consisting of lower and higher luminosity populations is required to reproduce both the overall BATSE sGRB number counts and a local burst distribution. Furthermore, the best-fitting parameters of the lower luminosity population agree well with the known properties of SGR giant flares, and the predicted numbers are sufficient to account for previous estimates of the local sGRB population.     

Biosorption of Rare-Earth Elements and Yttrium by Heterotrophic Bacteria in an Aqueous Environment

This paper reports the results of the experimental determination of the coefficient of sorption of rare-earth elements and yttrium (REY) under conditions of acidic pH using several strains of heterotrophic bacteria (Microbacterium sp., Curtobacterium sp., Bacillus subtilis, Pseudomonas putida, and Bacillus pumilis) that are widespread in natural and technogenic waters of the Far East (Russia). Insignificant fractionation between heavy and light rare-earth elements, negative cerium and dysprosium anomalies, and a positive europium anomaly were revealed. The selectivity of REY biosorption by gram-positive and gram-negative bacteria, as well as inertia of the biosorption process under more acidic conditions of the medium, were shown.     

Mean crustal velocity: a critical parameter for interpreting crustal structure and crustal growth

Mean crustal velocity is a critical parameter for genesis of continental crystalline crust because it is a function of mean crustal composition and therefore may be used to resolve continental crustal growth in space and time. Although the best values of mean crustal velocity are determined from wide-angle reflection measurements, most studied here necessarily come from vertical averages in crustal refraction determinations. The mode of 158 values of mean crustal velocity is 6.3 km/s, a velocity which corresponds to a mean crustal composition of granodiorite to felsic quartz diorite; Archean crust may be slightly more mafic. Mean crustal velocities range from 5.8 to 7.0 km/s. The lowest values invariably are found in thermally disturbed rift zones and the highest values correspond to velocities in gabbro. Velocities in island arcs may be as low as 6.0 km/s but are typically 6.5–6.9 km/s which corresponds to andesitic composition; estimates of island arc composition are andesitic. If values of mean crustal velocity are not biased, this observation suggests that continental crust did not grow simply by addition of island arc material. Possibilities are that crust formed from fusion of island arcs and was later changed to more felsic composition by addition of material from the mantle or that the late Archean episode of major crustal growth did not involve processes similar to younger island arcs. Some crustal blocks might be changed in composition and thickness by such processes as underplating, interthrusting, necking and sub-crustal erosion. Specially designed experiments are suggested to determine this parameter so critical for understanding genesis of continental crust.