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Excessive alcohol consumption leads to liver disease. Extensive evidence suggests that C-phycocyanin (C-PC), a chromophore phycocyanobilin derived from Spirulina platensis, exerts protective effects against chemical-induced organ damage. In this study, we investigated whether C-PC could protect against ethanol-induced acute liver injury. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride (TG), total cholesterol (CHOL), low-density lipoprotein (LDL), liver homogenate malondialdehyde (MDA), superoxide dismutase (SOD) content were measured, and pathological examination of liver sections were examined. C-PC showed obvious inhibitory effects on serum ALT, AST, TG, CHOL, LDL and MDA, and SOD content significantly increased in the liver. The structure of hepatic lobules was clear, liver sinus returned to normal, and liver cell cords were arranged in neat rows. Cloudiness, swelling, inflammatory cell infiltration and spotty necrosis of liver cells were significantly reduced. Therefore, C-PC can significantly protect against ethanol-induced acute liver injury. 相似文献
85.
Phenotypic and genetic parameters for growth-related traits in the half-smooth tongue sole, Cynoglossus semilaevis, were estimated in 22 full-sib families produced by normal and neo-male breeding stocks. As phenotypic males with female genotypes, neo-males are harmful in C. semilaevis aquaculture because they reduce overall production. The present study evaluated the difference in the growth-related traits: total length (TL), body weight (BW) and square root of body weight (SQ_BW) at the age of 570 days between normal and neo-male offspring (neo-males used as male parents). The difference in the proportion of females between normal and neo-male offspring was also assessed. Based on the linear mixed model, restricted maximum likelihood (REML) and best linear unbiased prediction (BLUP) were used to estimate various (co)variance components and estimated breeding values (EBVs) of growth-related traits. As a result, all the mean values of the three studied traits were significantly larger in normal offspring than in neo-male offspring. Additionally, the female proportion was significantly larger in normal offspring than in neo-male offspring. Heritability was 0.128±0.066 2 for TL, 0.128±0.065 5 for BW and 0.132±0.062 9 for SQ_BW, all of which were low level heritabilities. The correlation coefficients of EBVs and phenotypic values of the target traits were 0.516 for TL, 0.524 for BW and 0.506 for SQ_BW, all of which were highly significant (P <0.01). Genetic correlations among TL, BW and SQ_BW were positive high (0.921–0.969) and higher than those of phenotype (0.711–0.748), both of which had low standard errors (0.063–0.123 for genotype, and 0.010–0.018 for phenotype). Compared with normal offspring, neo-male offspring have lower breeding values for each studied trait through EBVs comparison. Therefore, neo-male offspring should not be used as broodstock in a C. semilaevis breeding programs. 相似文献
86.
Hydrogeology Journal - Quantifying groundwater/surface-water interactions is essential for managing water resources and revealing contaminant fate. There has been little concern on the exchange... 相似文献
87.
YuZhang Bi YanJun Du SiMing He XinPo Sun DongPo Wang XinPo Li Heng Liang Yong Wu 《Landslides》2018,15(5):1029-1043
In mountainous areas, channelized rock avalanches swarm downslope leading to large impact forces on building structures in residential areas. Arrays of rock avalanche baffles are usually installed in front of rigid barriers to attenuate the flow energy of rock avalanches. However, previous studies have not sufficiently addressed the mechanisms of interaction between the rock avalanches and baffles. In addition, empirical design approaches such as debris flow (Tang et al., Quat Int 250:63–73, 2012), rockfall (Spang and Rautenstrauch, 1237–1243, 1988), snow avalanches (Favier et al., 14:3–15, 2012), and rock avalanches (Manzella and Labiouse, Landslides 10:23–36, 2013), which are applied in natural geo-disasters mitigation cannot met construction requirements. This study presents details of numerical modeling using the discrete element method (DEM) to investigate the effect of the configuration of baffles (number and spacing of baffle columns and rows) on the impact force that rock avalanches exert on baffles. The numerical modeling is firstly conducted to provide insights into the flow interaction between rock avalanches and an array of baffles. Then, a modeling analysis is made to investigate the change pattern of the impact force with respect to baffle configurations. The results demonstrate that three crucial influencing factors (baffle row numbers, baffle column spacing, and baffle row spacing) have close relationship with energy dissipation of baffles. Interestingly, it is found that capacity of energy dissipation of baffles increases with increasing baffle row numbers and baffle row spacing, while it decreases with increasing baffle column spacing. The results obtained from this study are useful for facilitating design of baffles against rock avalanches. 相似文献
88.
Foundation soils are often under non-proportional cyclic loadings. The deformation behaviour and the mechanism of non-coaxiality under continuous pure principal stress rotation for clays are not clearly investigated up to now. In order to study the effect of pure principal stress rotation, a series of cyclic undrained tests on Shanghai soft clay subjected to cyclic rotation of principal stress directions keeping the deviatoric stress constant under the pure rotation condition were conducted using hollow cylinder apparatus. Based on this, the evolutions of excess pore pressure and strains during cyclic loading were investigated, together with the effects of the intermediate principal stress parameter and the deviatoric stress level on stress–strain stiffness and non-coaxiality. The result can provide an experimental basis for constitutive modelling of clays describing the behaviour under non-proportional loadings. 相似文献
89.
Sheng Hua Tan Shi Wei Wong Du Jia Chin Min Lee Lee Ying Hui Ong Siaw Yah Chong Azman Kassim 《Environmental Earth Sciences》2018,77(16):589
Rainfall-induced landslide is a common geohazard in tropical and humid regions. Capillary barrier system (CBS) is a popular and widely studied mitigating measure for rainfall-induced landslides. However, several previous studies have shown that the performance of the conventional CBS under intense rainfalls has not been particularly convincing. This paper aims to explore the feasibility and effectiveness of a newly proposed system, known as “biomediated capillary barrier system” (B-CBS) in minimizing water infiltration into soil. A one-dimensional soil column was used to investigate the infiltration characteristics of the proposed system. The results showed that the B-CBS of biomediated residual soil overlying original residual soil (Test IV) could effectively control the infiltration into soil by taking advantage of the less-permeable biomediated soil cover. The B-CBS of biomediated residual soil overlying gravelly sand (Test V) and the three-layered B-CBS of fine sand overlying gravelly sand and biomediated residual soil (Test VI) showed the best performance in terms of minimizing the water infiltration. A suction of about 5 kPa still remained in the soil column after 60 min of infiltration from the ponded water on the soil surface. 相似文献
90.
Yongquan Hu Qiang Wang Jinzhou Zhao Ziyi Guo Yong Zhang Chun Mao 《Environmental Earth Sciences》2018,77(23):778
The aim of the study involves examining the effect of heavy oil viscosity on fracture geometry in detail by establishing a heavy oil fracturing model and conventional fracturing model based on thermal–hydraulic–mechanical (THM) coupled theory, Walther viscosity model, and K–D–R temperature model. We consider viscosity and density within the heavy oil fracturing model as functions of pressure and temperature while that as constants within the conventional fracturing model. A heavy oil production well is set as an example to analyze the differences between the two models to account for the thermo-poro-elastic effect. The results show that temperature exhibits the most significant influence on the heavy oil viscosity while the influence of pressure is the least. In addition, a cooling area with a width of 0–1 m and varied length is generated near the fracture. The heavy oil viscosity increases sharply in this area, thereby indicating an area of viscosity increment. The heavy oil viscosity increases faster and is closer to wellbore, and a high viscosity increment reduces the mobility of the heavy oil and prevents the fracturing fluid from entering into the reservoir. The special viscosity distribution results in significant differences in pore pressure, oil saturation, and changing trends between these two models. In the heavy oil reservoir fracturing model, the thermal effect completely exceeds the influence of pore elasticity, and the values of the fracture length, width, and static pressure exceed those calculated in the conventional fracturing model. Thus, a comparison of the measured values indicates that the results obtained by considering viscosity as a function of temperature and pressure are more accurate. Therefore, the results of this study are expected to provide good guidelines for the design of heavy oil fracturing. 相似文献