基于网络药理学与分子对接探究连脂清肠汤治疗溃疡性结肠炎的作用机制

目的：应用网络药理学与分子对接技术探究连脂清肠汤（LQD）治疗溃疡性结肠炎（UC）的作用机制。方法：利用TCMSP和TCMID数据库收集LQD的活性成分及靶点,通过GeneCard、OMIM及TTD数据库获取UC疾病靶点,将药物与疾病靶点匹配得到共同靶点,使用Cytoscape 软件构建“中药-成分-靶点-疾病”网络图,将关键靶点导入STRING平台构建PPI网络,并用DAVID数据库对关键靶点进行基因本体（GO）功能、京都基因与基因组百科全书（KEGG）通路富集分析,利用Auto Dock Tools对筛选所得活性成分与靶点蛋白进行分子对接验证。结果：获得LQD有效活性成分123种,LQD作用靶点216个,UC靶点1189个,共同靶点117个。LQD治疗UC的主要活性成分包括槲皮素、山柰酚、柚皮素、甘草查尔酮a、芒柄花黄素等。核心靶基因包括信号转录活化因子3（STAT3）、转录因子激活蛋白1（JUN）、丝氨酸/苏氨酸激酶1（AKT1）、核转录因子-κB p65（RELA）、白细胞介素-6（IL-6）等。GO功能主要包括RNA聚合酶Ⅱ启动子转录的正调控、凋亡过程的负调控、细胞核、细胞溶质、细胞质、蛋白结合、酶结合等。KEGG通路主要有癌症通路、TNF信号通路、PI3K-Akt信号通路等。分子对接结果表明核心成分与核心靶点结合性较好。结论：LQD治疗UC具有多组分、多靶点和多通路的特点。     

Relation of Velocity Distribution and Mass for DA White Dwarfstwo

White dwarfs are the evolutionary endpoint of the low-and-medium mass stars. In the studies of white dwarfs, the mass of white dwarf is an important physical parameter. In this paper, we give an analysis about the velocity distribution of DA white dwarfs in the Sloan Digital Sky Survey (SDSS), and hope to find the relation between mass and velocity distribution of white dwarfs. We get the radial velocity and tangential velocity of every DA white dwarf according to their proper motion and spectral shift. Through analyzing the velocity distribution of DA white dwarfs, we find that the small-mass white dwarfs, which are produced from the single-star evolution channel, have a relatively large velocity dispersion.     

基于二分图的温度网络拓扑性质研究

利用中国地区435个台站1961—2002年逐日平均温度序列,将温度变化发生在9天时间尺度上的特征编码在网络中,通过研究二分图温度网络(BGT网络)中节点与项目的关系,揭示出9天时间尺度上温度变化的特征及其在空间上的拓扑统计性质.网络中各节点RRRD, RrDD, eeed, DRRD, DDRR等所代表的温度波动模态在网络中异常频发,对9天尺度温度变化的预报有一定的指导意义.统计网络的节点度分布,集群系数等拓扑结构特征量,发现BGT网络服从正态分布特征.BGT网络项目内节点度的多样性大体上     

Spatial and temporal distributions of nitrogen, phosphorus and heavy metals in the intertidal sediment of the Chang jiang River Estuary in China

Spatial and temporal distributions of nutrients (N and P) and heavy metals (Cu, Zn, Pb and Cd) in the intertidal sediments at Dongtan wetland of the Changjiang River (Yangtze River) Estuary were examined by laying one transect running seaward to landward during January, April, June, August and October of 2005. Total nitrogen (TN) and heavy metal concentrations in the intertidal sediment showed an increasing trend from open bare °at to the high marsh, with the maximum concentrations in the high marsh and the minimum values in open bare °at. In contrast, sediment total phosphorus (TP) concentrations changed little among sampling sites. One-way ANOVA found that there were signiˉcantly temporal variations of nutrients and heavy metals concentrations in the intertidal sediment (P <0.05). The concentrations of heavy metals generally showed an increasing trend from January to October. As compared with other large estuaries, heavy metal contamination in the intertidal sediment of the Changjiang River Estuary was relatively low.     

Difference-frequency ultrasound generation from microbubbles under dual-frequency excitation

The difference-frequency (DF) ultrasound generated by using parametric effect promises to improve detection depth owing to its low attenuation, which is beneficial for deep tissue imaging. With ultrasound contrast agents infusion, the harmonic components scattered from the microbubbles, including DF, can be generated due to the nonlinear vibration. A theoretical study on the DF generation from microbubbles under the dual-frequency excitation is proposed in formula based on the solution of the RPNNP equation. The optimisation of the DF generation is discussed associated with the applied acoustic pressure, frequency, and the microbubble size. Experiments are performed to validate the theoretical predictions by using a dual-frequency signal to excite microbubbles. Both the numerical and experimental results demonstrate that the optimised DF ultrasound can be achieved as the difference frequency is close to the resonance frequency of the microbubble and improve the contrast-to-tissue ratio in imaging.     

Ka波段毫米波云雷达对青藏高原东南缘降水回波的分析

利用丽江站新建的Ka波段毫米波云雷达获得的高时间分辨率的垂直观测资料,结合同址的地面自动气象站和雨滴谱的分钟数据、常规探空数据和附近C波段天气雷达的强度回波,分析了两次降水过程前后云雷达反射率因子Z、径向速度V_r、速度谱宽S_w的垂直变化规律。分析表明:在发生弱降水时,云雷达Z在垂直方向的变化不明显;但V_r、S_w值在0℃层稍低位置有一个明显的分界层(融化层),粒子通过融化层后V_r、S_w都是快速变大,这个变化主要是粒子的相态由固态变成液态引发的,可以通过V_r、S_w突变值的位置来识别0℃层亮带的高度。从C波段天气雷达回波强度、剖面图及云雷达位置的时间-高度图看,对毛毛雨和小雨的回波,强度和高度差异比较明显,毛毛雨比小雨回波高度低、强度弱,与云雷达相比C波段雷达对高一些的云观测不到,对距离较远的弱降水回波无法观测到;由于相同粒子对不同波长电磁波的散射不一样,造成两种雷达垂直方向观测到的Z变化不同。对比弱降水回波,云雷达在...     

陕南岚皋县柳家坡滑坡形成机制研究

柳家坡滑坡位于陕西岚皋县城北,属松散坡积物类滑坡。滑体为粘质砾砂土,渗透性差,受动水压力作用易发生流土;滑床为泥板岩和片岩。滑体和滑床工程地质性质差异明显,二者界面为滑体下滑的主滑面。该滑坡为一古滑坡,曾多次发生变形滑动,2003年在连续强降雨和坡脚切坡等因素诱发下重新活动,目前处于欠稳定状态,若遇强降雨仍有可能发生整体失稳。对陕西南秦岭区域滑坡调查表明无论是滑坡类型,还是滑坡体物质组成及变形规律,柳家坡滑坡在陕南都具有一定的代表性。     

岩溶在古地理研究中的作用——“关于古地理研究中若干原则问题的商榷”一文的补充及讨论

本文从现代、地史时期岩溶剥蚀速度及岩溶铝土矿的形成等方面探讨岩溶在古地理研究中的重大作用,从而提出稳定地区“缺失”某一时期地层,并非该时期为陆;而是前期仍有沉积,后期才真正上升为陆,遭受剥蚀。     

小尺度地形阻塞作用的数值试验

本文采用数值试验方法,讨论了一个高度只有200m的小尺度地形的阻塞作用,表明当大气低层的平均风速和温度层结使得Froude数小于1时,就有可能在地形的上风向形成阻塞。本文共试验了一般稳定层结、深厚逆温和浅薄逆温几种情况,讨论了数值结果和Froude数判别式之间的差异和原因,并计算了阻塞发生时的浓度分布。     

关于中国大陆五级以上地震的时间间隔问题

本文研究了我国大陆地区五级以上地震的时间间隔分布情况,发现我国大陆M_S≥5.0地震的时间间隔ΔT与其频次N_(ΔT)之间存在以下关系式:lgN_(ΔT)=2.14-0.15·ΔT本文还讨论了我国大陆出现长期无五级以上地震后,是否将有七级地震的问题。