常用剂量氟苯尼考在罗非鱼肝脏和肾脏中的消除规律及组织学影响

在水温28℃条件下,以12 mg/kg剂量对罗非鱼单次口服给药,采用HPLC方法测定不同时间实验鱼肝脏和肾脏中的药物水平,分析氟苯尼考在罗非鱼肝、肾组织的吸收及消除规律。结果显示,肝脏和肾脏中的药动学参数均符合药动学一室模型,肝脏的药物消除速度快于肾脏,消除半衰期T1/2β分别为4.89 h和15.93 h;药物在肝脏的Tmax为5.43 h,吸收峰值为4.84μg/g;59 h后肝、肾组织中的药物含量均低于0.8μg/g。取12 mg/kg剂量连续给药7 d的实验鱼肝、肾组织,进行组织学观察,结果显示,给药组罗非鱼的肝、肾组织均未出现病理性变化。此外,氟苯尼考对6株罗非鱼常见病原菌的体外抑菌实验中,最小抑菌浓度(MIC)均≤4 mg/L,表明常用剂量氟苯尼考在罗非鱼体内消除快、残留少且不造成组织损伤,对常见病原菌具有良好的抑菌效果。     

柴达木盆地西部新生界陆相湖盆碳酸盐岩沉积环境与沉积模式*

利用野外露头、岩心、测井录井和分析化验资料,对柴达木盆地西部(简称“柴西地区”)新生界干柴沟组湖相碳酸盐岩进行了研究,划分了其沉积微相类型,研究了其分布规律,分析其形成环境和控制因素,并建立了相应沉积模式。该区湖相碳酸盐岩在垂向上与碎屑岩频繁互层,湖相碳酸盐岩包括颗粒灰岩、藻灰岩、泥晶灰岩和混积岩4大类11种,划分出了灰泥坪、颗粒滩、藻丘(礁)、浅湖湾以及(半)深湖泥灰岩相等5种沉积微相。通过分析不同碳酸盐岩及其微相时空展布特征,认为其发育主要受控于湖盆构造运动、湖平面变化、陆源碎屑注入、古气候与古水介质条件、古地貌与古水深环境,并在此基础上建立了柴西湖相碳酸盐岩的沉积模式。研究认为柴达木盆地西部干柴沟组沉积时期,湖盆为典型咸化湖盆,构造活动相对稳定,湖平面上升达到峰值。碳酸盐岩主要发育在湖侵期,高频湖平面变化形成了碳酸盐岩与碎屑岩频繁互层。在枯水期,盆地坡折处发育碎屑岩滩坝或三角洲前缘沉积;在湖侵期,盆地坡折处发育了鲕粒滩及藻灰岩,盆地洼陷区发育泥灰岩或灰质泥岩。     

试论不同力学性质的断裂构造的富水部位及富水性

众所周知,断裂构造与地下水的关系相当密切。尤其是碳酸盐类岩石,岩溶极为发育并富含地下水,其原因在很大程度上与成岩以后的断裂构造有关。因此,研究不同力学性质的断裂构造的富水部位及富水性对于寻找地下水和查清矿区及各类工程的水文地质条件等,均有重要意义。     

吉林省冰雹天气的时空分布

对1990～2003年4～10月吉林省9个市(州)51个气象站冰雹天气的降雹日数、年分布、年变化、日变化和降雹的主要路径等时空分布特征进行统计分析。把近14年与过去30年吉林省冰雹天气气候特征相比较,除冰雹年变化和日变化无差异外,降雹日数年分布和主要冰雹路径有所不同。分析表明,近14年降雹线共9条,大部分大致呈NW-SE走向,其中有2条SW-NE向降雹线穿过全省中部地区。     

GM4磁通门磁力仪秒数据转换及断记报警软件的开发与应用

使用Java编程语言,编写GM4磁通门磁力仪秒数据转换分数据和断记监视软件.秒数据转分数据的方法是,取整分前后45个数据进行高斯滤波,计算得到分钟值,生成的分钟值文件符合geomag软件要求的数据格式.断记监视的方法是,监视实时生成的数据文件字节数是否持续增加,监视H分量观测值是否恒值,避免仪器走直线而不能及时发现,如果事件发生,触发报警.     

A preliminary study on the climatic and environmental changes at the turn from pleistocene to holocene in East Asia

This paper examines the regional climatic and environmental changes from the late Pleistocene to middle Holocene in Central-East Asia. A review is made of the published literature that are specific to pelaeoclimate and physical environment in some geographical regions.It is shown that (1) during the late Pleistocene the annual mean temperature was 5°–6° C lower than present in Qinghai-Xizang (Tibet) plateau, 6° to 9° C lower than today in NE China, 6° C lower than today in E China, and 4° C lower than present in Taiwan island; (2) during the middle Holocene, the annual mean temperature was 4° C warmer than present in Qinghai-Xizang (Tibet) plateau, 3° to 4° C warmer than today in NE China, 2° to 3° C warmer than today in Shanghai area, and only 2° to 2.5° C warmer in Taiwan island.     

辽东湾北部地区走滑构造特征与油气富集规律

辽东湾北部地区右行走滑构造特征较为典型,主要表现为:沿走滑断裂带发育雁行式伸展断裂;剖面上发育花状构造;走滑断裂沿走向呈“S”型或反“S”型波状弯曲;沿走滑断裂带断槽与断鼻构造相间分布。分析认为,渐新世晚期,辽东湾北部地区南北向拉张、东西向挤压的区域应力场控制了右行走滑构造的形成,断槽与断鼻构造相间分布是由于沿走滑断裂带局部应力场性质发生改变所致。右行走滑断裂的“S”型弯曲部位为增压弯部位,走滑断裂两侧断块在此汇聚,地层因应力集中而形成断鼻构造;右行走滑断裂的反“S”型弯曲部位为释拉张部位,走滑断裂两侧断块在此离散,地层因拉张而发生断陷形成断槽。受走滑构造所控制,油气沿走滑断层自断槽向断鼻方向运移、聚集而成藏。研究走滑构造发育特征,对于预测圈闭分布以和研究油气富集规律具有重要意义。     

纤维对石灰改良膨胀土性质的影响分析

首先对膨胀土基本性质做了试验分析,通过天然膨胀土和掺人纤维前后的石灰土的击实试验,得出了掺人少量纤维对石灰土的最优含水率和最大干密度影响很小.通过有荷膨胀率试验,得出了纤维能够抑制石灰土的膨胀性,纤维掺人量在0.05%～0.1%之间时,线膨胀率随纤维掺人量的增多而降低显著,在0.1%～0.2%之间时降低幅度减小.由无侧...     

Simulating the effect of hydrate dissociation on wellhead stability during oil and gas development in deepwater

It is well known that methane hydrate has been identified as an alternative resource due to its massive reserves and clean property. However, hydrate dissociation during oil and gas development (OGD) process in deep water can affect the stability of subsea equipment and formation. Currently, there is a serious lack of studies over quantitative assessment on the effects of hydrate dissociation on wellhead stability. In order to solve this problem, ABAQUS finite element software was used to develop a model and to evaluate the behavior of wellhead caused by hydrate dissociation. The factors that affect the wellhead stability include dissociation range, depth of hydrate formation and mechanical properties of dissociated hydrate region. Based on these, series of simulations were carried out to determine the wellhead displacement. The results revealed that, continuous dissociation of hydrate in homogeneous and isotropic formations can causes the non-linear increment in vertical displacement of wellhead. The displacement of wellhead showed good agreement with the settlement of overlying formations under the same conditions. In addition, the shallower and thicker hydrate formation can aggravate the influence of hydrate dissociation on the wellhead stability. Further, it was observed that with the declining elastic modulus and Poisson’s ratio, the wellhead displacement increases. Hence, these findings not only confirm the effect of hydrate dissociation on the wellhead stability, but also lend support to the actions, such as cooling the drilling fluid, which can reduce the hydrate dissociation range and further make deepwater operations safer and more efficient.