大亚湾西部海域沉积物中生物硅的含量及其分布特征

采用2. 0 mol/dm~3Na_2CO_3溶液5h单点化学提取-硅钼蓝连续分光光度分析法分别测定了大亚湾西部海域13个表层沉积物和1个沉积物岩芯中生物硅的含量.表层沉积物和沉积物岩芯中生物硅含量占比分别为0. 69%～2. 02%和1. 24%～2. 05%,平均值分别为1. 42%和1. 60%.结果证实西大亚湾沉积物中生物硅含量水平与我国南海近岸海域基本一致.在210Pbex测年的基础上,通过分析沉积物岩芯中生物硅、有机物、无机碳等多指标,揭示近百年来大亚湾周边环境变化对海洋环境的影响,证实了上世纪80年代以来西大亚湾周边农业、海水养殖业和工业发展等人类活动加剧了该海域生态环境变化,尤其90年代核电站运行对海洋生态变化造成一定的影响.     

柔肝通络汤治疗脑梗死急性期40例临床观察

目的：观察柔肝通络汤治疗脑梗死急性期（阴虚络瘀证）的临床疗效。方法：将脑梗死急性期（阴虚络瘀证）患者80例,随机分为2组,每组各40例。治疗组采用柔肝通络汤治疗,对照组采用西医常规治疗。结果：综合疗效总有效率治疗组为87.5%,对照组为72.5%,组间比较,差异有统计学意义（P＜0.05）;中医证候疗效总有效率治疗组为90.0%,对照组为75.0%,组间比较,差异有统计学意义（P＜0.05）;2组血液流变学指标、NIHSS评分治疗前后组内比较及治疗后组间比较,差异均有统计学意义（P＜0.01）。结论：柔肝通络汤治疗脑梗死急性期（阴虚络瘀证）有较好疗效,优于西医常规治疗。     

龙胆祛湿汤加减联合海棠丁香凝胶治疗亚急性湿疹36例

目的：观察龙胆祛湿汤加减联合海棠丁香凝胶治疗亚急性湿疹（湿热蕴肤型）的临床疗效。方法：将76例亚急性湿疹（湿热蕴肤型）患者随机分为治疗组36例与对照组40例。治疗组采用龙胆祛湿汤加减联合海棠丁香凝胶治疗,对照组采用盐酸左西替利嗪治疗。观察2组治疗前后症状体征评分,评定临床疗效。结果：总有效率治疗组为97.22%,对照组为82.50%,组间比较,差异有统计学意义（P<0.05）。结论：龙胆祛湿汤加减联合海棠丁香凝胶治疗亚急性湿疹（湿热蕴肤型）的临床疗效优于盐酸左西替利嗪治疗,值得临床推广应用。     

基于DPPH-HPLC-Q-TOF-MS/MS技术的安化黑茶发酵前后抗氧化活性物质基础研究

目的：建立基于高效液相色谱串联四级杆飞行时间质谱技术（HPLC-Q-TOF-MS/MS）的安化黑茶抗氧化活性成分快速筛选和鉴别的方法,并对安化黑茶生茶及熟茶的抗氧化活性成分分别进行检测和分析。方法：采用Inertsil ODS-2C_{18色谱柱（250mm×4.6mm,5μm）反相HPLC梯度洗脱法分离各主要成分,在负离子模式下,利用四级杆-飞行时间串联质谱对各主要活性成分进行检测;进而在安化黑茶生茶及熟茶乙酸乙酯及正丁醇部位分别加入适量1,1-二苯基-2-苦基苯肼（DPPH）作为实验组,避光室温反应30min后经液质联用分析,并与不加入DPPH的空白组物质进行比较,快速发现其活性成分;并采用对照品、文献比对、质谱裂解规律分析鉴定生茶、熟茶的抗氧化活性成分。结果：依据质谱裂解规律及文献检索,从安化黑茶生茶乙酸乙酯部位中共鉴定出32个抗氧化活性成分,从生茶正丁醇部位中共鉴定出28个抗氧化活性成分;从熟茶乙酸乙酯部位中共鉴定出31个抗氧化活性成分,从熟茶正丁醇部位中共鉴定出26个抗氧化活性成分。结论：利用DPPH-HPLC-Q-TOF-MS/MS技术快速筛选和鉴别安化黑茶中抗氧化活性成分的有效方法,为其质量控制及物质基础研究提供了技术支持。}     

Contribution of trimethylamine N-oxide on the growth and pressure tolerance of deep-sea bacteria

Trimethylamine N-oxide(TMAO) is widely dispersed in marine environments and plays an important role in the biogeochemical cycle of nitrogen. Diverse marine bacteria utilize TMAO as carbon and nitrogen sources or as electron acceptor in anaerobic respiration. Alteration of respiratory component according to the pressure is a common trait of deep-sea bacteria. Deep-sea bacteria from dif ferent genera harbor high hydrostatic pressure(HHP) inducible TMAO reductases that are assumed to be constitutively expressed in the deep-sea piezosphere and facilitating quick reaction to TMAO released from ?sh which is a potential nutrient for bacterial growth. However, whether deep-sea bacteria universally employ this strategy remains unknown. In this study, 237 bacterial strains affliated to 23 genera of Proteobacteria,Bacteroidetes, Firmicutes and Actinobacteria were isolated from seawater, sediment or amphipods collected at dif ferent depths. The pressure tolerance and the utilization of TMAO were examined in 74 strains. The results demonstrated no apparent correlation between the depth where the bacteria inhabit and their pressure tolerance, regarding to our samples. Several deep-sea strains from the genera of Alteromonas, Halomonas,Marinobacter, Photobacterium, and Vibrio showed capacity of TMAO utilization, but none of the isolated Acinebacter, Bacillus, Brevundimonas, Muricauda, Novosphingobium, Rheinheimera, Sphingobium and Stenotrophomonas did, indicating the utilization of TMAO is a species-speci?c feature. Furthermore, we noticed that the ability of TMAO utilization varied among strains of the same species. TMAO has greater impact on the growth of deep-sea isolates of Vibrio neocaledonicus than shallow-water isolates. Taken together, the results describe for the ?rst time the TMAO utilization in deep-sea bacterial strains, and expand our understanding of the physiological characteristic of marine bacteria.     

GNSS精密轨道产品不连续性分析及评估

按照目前的国际规范, 高精度GNSS (Global Navigation Satellite System)轨道产品一般以天为周期进行发布, 提供给用户使用. 连续使用多天的产品存在不同天间的跳变问题. 利用德国地学研究中心(GFZ)、欧洲定轨中心(COD)、欧空局(ESA)、美国喷气试验室(JPL)以及上海天文台(SHA)共5个GNSS分析中心2013---2017年的轨道产品, 分析了轨道跳变的特性. 计算结果表明: GFZ、COD、ESA、SHA和JPL的3维轨道跳变平均分别为7.79cm、1.51cm、7.77cm、11.75cm和2.51cm. 轨道跳变序列的周期特性分析表明: 序列存在90d、120d、340d左右的显著周期项, 对应于海潮对地球自转的影响, 其振幅为数毫米至1cm左右. 表明精密轨道确定需要进一步精化该项模型; GPS的跳变序列还存在与卫星星座相关的175d和352d左右的交点年显著周期项. 此外, 针对COD产品外推轨道的分析, 验证了地球反照辐射压和太阳光压模型等动力学模型对轨道的差异.     

Status of Satellite Orbit Determination and Time Synchronization Technology for Global Navigation Satellite Systems

In the form of satellite ephemerides and clock parameters, the space datum and system time information of one global navigation satellite system (GNSS) is transferred to users. With the continuous updating in the satellite payload such as the high-precision atomic clock, the monitoring and tracking technique such as the inter-satellite link, and in the data processing technique, the accuracy and real-time performance of the satellite ephemeris and clock error products are steadily improved. Starting from December 27th, 2018, the BeiDou Navigation System 3, or BDS-3, has provided the accurate and reliable basic positioning, navigation, and timing (PNT) service for the users in the countries within the “one belt and one road”. This paper has summarized the faced challenges of the precise orbit determination and time synchronization from the regional BDS-2 system to the BDS-3 global system, and the specific solutions at the control segment. In addition, this paper has compared the BDS with other GNSS systems in terms of technical characteristics. Finally, aiming at a higher accuracy and more reliable PNT service, the road map of precise orbit determination and time synchronization technique for the next generation navigation systems is discussed, which will provide a reference for developing the global navigation satellite systems with an even higher accuracy.     

北斗星地双向时频传递与广广播钟差精度分析

与其他卫星导航系统不同,北斗卫星导航系统采用星地双向时间比对技术,直接测量卫星钟相对于地面保持的系统时间的钟差,并用于广播电文钟差参数的建模。讨论了电离层延迟误差、卫星相位中心误差等不同误差源对不同类型卫星双向时间同步卫星钟差精度的影响。实测数据分析结果表明,星地双向卫星钟差内符合精度(RMS)优于0.15 ns。利用双向卫星钟差序列,对广播星历钟差参数预报精度进行了分析,统计结果显示广播电文钟差参数预报1 h,精度在2 ns以内,移动卫星刚入境时,钟差参数预报6 h误差可达10 ns。     

COSMO-SkyMed颜色变换强度RC法南京建设用地变化检测

基于非局部滤波的SAR强度RC合成变化检测法对小图斑、线型地物等动态监测灵敏,且对数据获取无时空基线要求,在多云多雨城市地表要素变化检测中具备潜力。本文研究以多时相SAR强度RC合成图为数据源,提出一种基于色彩空间变换的变化图斑半自动提取方法,即通过色彩空间转换、训练样本选取、监督分类影像分割、变化区域提取4步骤,可实现基于SAR强度图的城市建设用地动态监测与图斑高效更新。选取南京河西新城与江北新区为示范,以最优参数配置（3特征向量与10样本类别）进行试验,实现了优于88%的建设用地查准率指标。     

不同GPS掩星电离层剖面产品相关性分析

将在一定时空限定范围内的不同低轨卫星COSMIC、GRACE、CHAMP、FY3C的电离层掩星电子密度剖面定义为一个掩星对来对比分析不同类型掩星电离层产品。结果表明：COSMIC掩星对之间的电子密度剖面整体轮廓符合得很好,电子密度剖面主要在250 km以下和500 km以上存在较大的偏差,250~500 km的电子密度整体偏差较小,统计得到的COSMIC掩星对的电子密度参量NmF2和hmF2的相关系数能分别达到0.99和0.97,具有高度相关性,不同COSMIC卫星之间没有明显的系统误差;COSMIC、GRACE、CHAMP和FY3C不同低轨卫星间的电子密度剖面略有差异,通过统计电子密度参量NmF2和hmF2之间的相关系数,COSMIC和CHAMP的相关系数分别为0.95和0.86,COSMIC和GRACE的相关系数分别为0.98和0.94,COSMIC和FY3C的相关系数分别为0.96和0.92,不同掩星类型之间的电子密度参量之间也具有高度相关性,验证了不同卫星任务GPS掩星电离层剖面的一致性。