健脾柔肝息风汤对抽动障碍模型大鼠行为学及多巴胺受体mRNA表达的影响

目的：探讨健脾柔肝息风汤对抽动障碍模型大鼠运动性抽动的调节机制,为临床治疗抽动障碍提供实验依据。方法：将60只SD大鼠随机分为空白组,模型组,氟哌啶醇组,健脾柔肝息风汤低、中、高剂量组,每组各10只,除空白组外各组大鼠连续7 d腹腔注射亚氨基二丙腈（IDPN）造模,造模成功后连续灌胃6周,灌胃后第1、3、6周分别观察大鼠的行为学改变,采用RT-PCR法检测大鼠脑组织DRD1 mRNA、DRD2 mRNA含量。结果：灌胃6周后,与模型组比较,健脾柔肝息风汤中、高剂量组及氟哌啶醇组在运动行为评分、刻板行为评分及DRD1 mRNA含量方面均有所下降（P<0.05）;而健脾柔肝息风汤低、中、高剂量组及氟哌啶醇组在DRD2 mRNA含量方面有所下降（P<0.05）。结论：健脾柔肝息风汤可通过降低TD模型大鼠脑组织多巴胺DRD1 mRNA、DRD2 mRNA的含量,而改善TD模型大鼠运动性抽动行为。     

机载LiDAR地形特征信息快速提取

为更有效地获取地形特征信息,提出一种机载LiDAR地形特征信息快速提取算法。首先,通过构建二次曲面拟合模型,建立实测LiDAR地形数据与拟合曲面的几何规则;然后,采用LM算法迭代参数寻优,获得最优化结果下的地形拟合参数,计算拟合时间及拟合精度;最后,以地形拟合模型为基础,进行地形特征信息的快速提取。通过机载LiDAR实测数据验证,当最优搜索半径为2 m时,地形曲面的拟合时间仅为0.02 s,RMSE仅为5.09 cm。该算法保证了地形特征信息提取效率和精度,能够有效满足机载LiDAR科学研究和工程应用的技术需求。     

尼泊尔地震的NOAA卫星数据震前异常分析

发生地震时常伴随有地热辐射增强现象,这些异常信息隐藏于遥感卫星NOAA所捕获的地球射出长波辐射（OLR）数据中,目前多数研究还停留在对源数据的解读,缺乏有效的信息处理技术,致使大部分的OLR数据没有得到充分利用。因此,本文提出一种基于鞅理论的概率统计方法来识别异常特征算法,从有噪声的非结构化的源数据中提取出震前OLR数据异常变化特征序列,从时间序列和地域范围进行震前异常分析。本算法实验是以尼泊尔的在2014年9月至2015年7月期间（包括2015年4月25日Ms7.8大地震）发生的3次地震的OLR数据为例,实验结果显示震中区域的OLR数据在震前的2~3个月开始有显著的异常数据变化,通过分析发现数据显示数据异常在震前出现的时间长短与地震的大小相关,异常的发生区域与震区周围的地貌特征相关。这说明基于鞅理论的算法所提取的OLR数据异常点序列的确与地震发生的时间地点是有关系的。     

Bearing capacity of offshore umbrella suction anchor foundation in silty soil under varying loading modes

Considering the current disadvantages of present offshore wind turbine foundations, a novel anchor foundation with skirt and branches is proposed, called offshore umbrella suction anchor foundation (USAF). A series of experiments and numerical simulations were performed to explore the bearing capacity of the USAF under various kinds of loading modes. The bearing characteristics and the anchor–soil interactions are described in detail for horizontal static loading, horizontal cyclic loading, and an antidrawing (pullout) test in silty soil. In the static loading test, the load–deflection of the anchor under step loading was analyzed and the normalized curve of the load–deflection was obtained to determine the ultimate horizontal bearing capacity of the anchor under normal working conditions. Under horizontal cyclic loading, the relationship between the plastic cumulative deformation and cyclic number was determined. In addition, the responses of USAF were investigated for a low wave frequency and storm surges. In the drawing test, it was found that a “segmentation phenomenon” occurred during the test. Moreover, a method to identify the maximum antidrawing load of USAF was provided based on dynamic mechanics. The numerical results show that the use of anchor branches and skirt can enhance the bearing performance of USAF to a certain degree. However, the anchor branch has a slight positive influence on the bearing performance improvement. The USAF is not only similar to a stiff short pile, but a rotation occurs. The failure envelope under composite loading (V-M) was obtained and the changes associated with changes in the aspect ratio of the internal compartment were clarified.     

脐带缆螺旋滑移分析及力学性能研究

针对脐带缆内部螺旋层,应用Darboux标架建立螺旋结构空间坐标系,推导弯曲载荷下螺旋结构的局部变形和滑移。考虑螺旋构件间的接触和摩擦作用,建立螺旋结构的受力平衡偏微分方程,并研究螺旋角和摩擦系数对螺旋结构滑移的影响。基于同层螺旋结构本构关系相同假设,将所有螺旋结构力学性能线性叠加,拟合脐带缆整体弯曲刚度。运用建立的理论解析方法,对某双层铠装脐带缆的力学性能进行研究,并与数值模拟结果进行对比验证。对比结果表明,理论解析得到的螺旋滑移结果与数值模拟结果一致,理论解析得到的脐带缆弯曲刚度与数值模拟结果在全滑动阶段比较接近。     

退火对B掺杂纳米金刚石薄膜微结构和电化学性能的影响

采用热丝化学气相沉积法制备B掺杂纳米金刚石薄膜,并对薄膜进行真空退火处理,系统研究了不同退火温度对B掺杂纳米金刚石薄膜的微结构和电化学性能的影响.结果表明,当退火温度升高到800 ℃后,薄膜的Raman谱图中由未退火时在1157,1346,1470,1555 cm^-1处的4个峰转变为只有D峰和G峰,说明晶界上的氢大量解吸附量减少;并且D峰和G峰的积分强度比I_D/I_G值变为最小,即sp²相团簇     

Role of buffer layer in electronic structures of iron phthalocyanine molecules on Au(111)

We investigate the electronic structures of one and two monolayer iron phthalocyanine (FePc) molecules on Au(111) surfaces. The first monolayer FePc is lying flat on the Au(111) substrate, and the second monolayer FePc is tilted at ～15° relative to the substrate plane along the nearest neighbour [101^-] direction with a lobe downward to the central hole of the unit cell in the first layer. The structural information obtained by first-principles calculations is in agreement with the experiment results. Furthermore, it is demonstrated that the electronic structures of FePc molecules in one-monolayer FePc/Au(111) system are perturbed significantly, while the electronic structures of FePc molecules in the second monolayer in two-monolayer FePc/Au(111) system remain almost unchanged due to the screening of the buffer layer on Au(111).     

Modelling the effect of wave overtopping on nearshore hydrodynamics and morphodynamics around shore-parallel breakwaters

Wave overtopping nearshore coastal structures, such as shore-parallel breakwaters, can significantly alter the current circulation and sediment transport patterns around the structures, which in turn affects the formation of tombolos and salients in the nearshore area. This paper describes the implementation of a wave overtopping module into an existing depth-averaged coastal morphological mode: COAST2D and model applications to investigate the effect of wave overtopping on the hydrodynamics and morphodynamics around a group of shore-parallel breakwaters. The hydrodynamic aspects of the model were validated against a series of laboratory conditions. The model was then applied to a study site at Sea Palling, Norfolk, UK, where 9 shore-parallel segmented breakwaters including 4 surface-piercing and 5 low-crested breakwaters are present, for the storm conditions in Nov 2006. The model results were compared with laboratory data and field measurements, showing a good agreement on both hydrodynamics and morphological changes. Further analysis of wave overtopping effect on the nearshore hydrodynamics and morphodynamics reveals that wave overtopping has significant impacts on the nearshore circulation, sediment transport and the resulting morphological changes within such a complex breakwater scheme under the storm and macro-tide conditions. The results indicate the importance of including the wave overtopping in modelling nearshore morphodynamics with the presence of coastal structures.     

巴丹吉林沙漠北缘拐子湖流沙下垫面近地层湍流强度和陆面过程特征

利用巴丹吉林沙漠北缘拐子湖流沙下垫面2013年7、10月和2014年1、4月的湍流通量资料,计算并分析了研究区近地层湍流强度,同时针对风速分量、温度、水汽和CO₂归一化标准差随稳定度的变化关系和总体输送系数等陆面过程特征进行分析。结果表明：（1）风速各分量的湍流强度均随风速的增加逐渐减小,风速处于2 m·s^-1以下时湍流发展最为旺盛。湍流强度主要由水平方向风速分量决定,垂直方向风速的作用较小,且近中性和不稳定层结利于湍流的发展。与其他地区相比,平坦且没有建筑物的沙漠地区,机械湍流较弱,湍流强度相应较小。（2）风速各分量的归一化标准差与稳定度（z/L）均满足1/3次方函数规律,其中垂直方向风速分量的拟合曲线方程较好。（3）动量输送系数C_d具有明显的夏季高、冬季低的变化状态且各月的日变化形态均呈夜间低、日间高的循环形态。热量输送系数C_h的不同月份日变化间并没有明显的排列次序,且日出日落前后具有明显的波动。不稳定层结时,C_d和C_h均随风速的增加逐渐减小;稳定层结时,C_d和C_h均随着风速的增加逐渐上升。     

Cloning and phylogenetic analysis of a fatty acid elongase gene from Nannochloropsis oculata CS179

Nannochloropsis oculata CS179, a unicellular marine microalga, is rich in long-chain polyunsaturated fatty acids (LCPUFAs). Elongase and desaturase play a key role in the biosynthesis of PUFAs. A new elongase gene, which encodes 322 amino acids, was identified via RT-PCR and 5′ and 3′ RACE. The sequence of the elongase gene was blast-searched in the NCBI GenBank and showed a similarity to those of the cryptosporidium. But the NJ-tree revealed that the N. oculata CS179 elongase clustered with those of the microalgae Phaeodactylum tricornutum, Ostreococcus tauri and Thalassiosira pseudonana.