卫矛醇对C6胶质瘤细胞体外抗癌活性及机制探讨

目的:研究卫矛醇对C6胶质瘤细胞株的体外增殖及凋亡的影响。方法：将C6大鼠胶质瘤细胞随机分为对照组、卫矛醇干预组、卫矛醇+雷帕霉素组、卫矛醇+3-MA组,各组予不同药物孵育,采用MTT法检测卫矛醇对C6细胞的体外增殖抑制率,筛选出抑制率相对较高且生长状态良好的细胞;应用Hoechest 33342染色透射电镜观察细胞凋亡亚显微结构的改变,采用免疫荧光和Western Blot技术检测与凋亡和自噬相关蛋白的表达水平。结果:卫矛醇对C6胶质瘤细胞增殖有明显的抑制作用,并呈现出良好的浓度-效应相关性,与对照组比较,随着浓度的增加,细胞的增殖抑制率上升(P＜0.01);Hoechst染色结果显示,与对照组相比,共同孵育卫矛醇24 h后的C6细胞出现明显的核固缩现象,证明有大量的细胞出现凋亡;Western Blot结果显示,与对照组相比,促凋亡基因Bax表达上调,抗凋亡基因Bcl-2表达下调。结论:卫矛醇能够抑制C6细胞的增殖,并诱导其凋亡,其作用机制可能与上调Bax、下调Bcl-2有关。     

贵州雾的时空分布特征

采用贵州84个测站累计44a的雾资料,分别从各站多年平均雾日、各站累年出现雾日最多的月份及日数、各站雾最长持续时间、白天雾与夜间雾的概率分布等要素入手,分析贵州雾的时空分布气候特征.     

电阻率图像中的地下水和断层

目的：将电阻率层析成像应用于探测潜伏断层的研究中，本文发现了断层和地下水的一些基本电阻率分布特征，这对于工程物探意义重大，一般情况下，断层两侧具有不同的电阻率特征，但是，根据电阻率层析图像中的电阻率分布，通常难以区分断层和地下水层，这是因为两者不仅都具有低电阻率值，而且还具有非常相似的电阻率异常特征。资料和方法：运用电阻率层析图像的数据，电阻率层析图像中的断层会呈现如下特征：1）由于孔隙度的加大和地下水的存在，使得断层表现出高角度的低阻线性结构。它们既可以出现在浅部盖层中，也可以存在于深部基岩中，特别是在深部区域，它们尤为明显；2）它们还呈现出高角度的线性梯度带，在该梯度带两边的电阻率结构出现整体性的差异，通常情况下，正断层的上盘表现出低阻或／和班驳状的高阻和低阻扰动区，而下盘则为完整的高阻区，这与逆冲断层正好相反；3）与断层有关的电阻率异常区常常具有良好的大尺度水平连续性，并且可以追瞎异常区附近的精细电性结构。而地下水的电阻率特征为：1）如果没有裂隙，地表水所引起的低阻区非常浅，即使存在丰富的水源以及高孔隙度的砾岩和中粗砂。一般情况下，其底端深度不超过强风化区；2）地下水的电阻率值非常低，特别在高矿化度的地区。地下水，包括岩溶水和砂岩水，的电阻率总显示出局部水平延伸或／和面团状特征；3）地下水层的深度朝某个固定方向逐渐增加，并且其电阻率图像会随季节而变；4）一般情况下，在水下渗的地区，会出现降水漏斗，其上部为高阻，而下部为低阻，从而便形成了“Y”或“V”字型的典型结构。结果：利用上述的基本特征一般可以区分断层和地下水。结论：仅依靠电阻率层析图像，可能极难准确地区分断层和裂隙水，这是因为裂隙水不但可能具有高角度的低阻线性结构，而且在一定尺度上具有很好的水平连续性，还有，由于电阻率层析成像较差的垂直分辨率，难以精确确定断层的上端点位置，所以结合其它的物探手段如钻探和浅层地震勘探是非常必要的。     

Sedimentary cycles of trace elements in Salawusu River Valley since 150 ka BP

The paper makes some analyses on 11 trace elements in the Milanggouwan stratigraphical section in the Salawusu River valley, which is regarded as a prototype geology-palaeoclimate record since 150 ka BP. The results show that the content and variation of trace elements has experienced remarkably regular changes in the pace with coarse and fine sedimentary cycles of palaeo-aeolian sands to its overlying fluvio-lacustrine facies or/and palaeosols. The trace elements with chemical properties of relatively active (V, Sr, Cu, Ni, As) and relatively stable (P, Pb, Rb, Mn, Nb, Zr) are a manifestation of the corresponding 27 changeable cycles between peak and valley values, appearing a multi-fiuctuational process line of relative gathering and migration since then. The low numerical value distribution of these two types of trace elements in the aeolian sand facies represents erosion and accumulation under wind force during the cold-dry climate. Whereas their enrichments in both fluvio-lacustrine facies and palaeosols are related to the valley’s special low-lying physiognomic position between the Ordos Plateau and the Loess Plateau under the warm and humid climate conditions. The above relatively migrated and gathered change of the trace elements is the result of 27 climatic cycles of cold-dry and warm-humid, which is probably caused by repeated alternations of winter monsoon and summer monsoon in the Mu Us Sandy Land influenced by the climate vicissitudes in northern hemisphere during glacial and interglacial periods since 150 ka BP.     

A general model for estimating actual evaporation from non-saturated surfaces

Based on energy balance equation and mass transfer equation, a general model to estimate actual evaporation from non-saturated surfaces was derived. Making use of two concepts, “relative evaporation” and “relative drying power”, a relationship was established to account for the departure from saturated conditions. Using this model, the actual evaporation (evapotranspiration) can be calculated without the need of potential evaporation estimation. Furthermore, the model requires only a few meteorological parameters that are readily and routinely obtainable at standard weather stations. Based on nearly 30 years data of 432 meteorological stations and 512 hydrological stations in China, in combined with GIS, nine typical river basins were selected. Using the data of the selected river basins, the model was tested. The results show that the actual evaporation rate can be estimated with an error of less than 10% in most areas of China, except few years in the Yellow River Basin.     

Study of crustal structure with S—wave data from Maqen—Jingbian profile

2-D crustal velocity structure and vp/vs are obtained by processing and interpretation of S-wave data from Maqen-Jingbian deep seismic sounding(DSS)profile.The result shows that there exist obvious differences in 2-D S-wave velocity structure and vp/vs ratio structure along the profile.The S-wave velocities are low and vp/vs ration is high for the westem section of the profile and Haiyuan region,while they are normal for the middle and eastern sections.The changes in lithologic characters of two major anomalous zones are discussed according to lateral variation of S-wave velocity structure and vp/vs ratio structure.It is concluded that the development and occurrence of the Haiyuan strong earthquake is not only related to tectonic activities,but also to lithologic characters of the region.     

壳幔混染作用——下扬子区早中生代玄武岩同位素地质特征

下扬子区中生代（231Ma）玄武质火山岩全岩εNd（t）值-8.62～1.92,87Sr/86Sr 值0.7074～0.7179，206Pb/204Pb值为17.786～18.323。岩石中含有前寒武纪捕虏晶锆石。研究表明玄武质岩石可能是由亏损地幔与元古宙地壳岩石混染作用的结果。     

人地非线性相关作用的探讨

从自组织系统思想出发，提出了人地关系的基本特性，通过逻辑斯蒂听数学变换，分析了人地非线性相关作用的混沌特性，进而讨论了人地关系的分形性质。基于混 过程与分形结构的因果关系，指出：地球表层系统中的人文分形景观乃是人地非线性关系的混沌作用所致。     

泥炭档案气候变化重建的定量模型

泥炭档案气候变化重建的定量模型＊陶发祥洪业汤（中国科学院地球化学研究所，贵阳５５０００２）李汉鼎冷雪天（东北师范大学地理系，长春１３００２４）关键词泥炭档案纤维素稳定同位素气候变化定量模型用泥炭档案定量重建大气ＣＯ２浓度的研究已取得重要进展［１］，但...     

巴楚-伽师Ms6.8地震地磁异常特点分析

通过分析、比较1996--2003年喀什地震台站记录到的新疆伽师及附近地区发生的多次6级地震的地磁前兆异常特征，发现在这几组地震活动过程中喀什地震台的地磁表现出不同的异常特征，说明与地震破裂特征有更深层次的相关性，且地磁响应比异常和总强度差值异常在一定程度上反映了台站周围小范围的震源区介质电性结构的变化。巴楚-伽师6．8级地震前地磁异常特征并不十分突出，有别于1996—1998年伽师强震群震前地磁异常量较丰富的特点。