Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice

Excessive alcohol consumption leads to liver disease. Extensive evidence suggests that C-phycocyanin (C-PC), a chromophore phycocyanobilin derived from Spirulina platensis, exerts protective effects against chemical-induced organ damage. In this study, we investigated whether C-PC could protect against ethanol-induced acute liver injury. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride (TG), total cholesterol (CHOL), low-density lipoprotein (LDL), liver homogenate malondialdehyde (MDA), superoxide dismutase (SOD) content were measured, and pathological examination of liver sections were examined. C-PC showed obvious inhibitory effects on serum ALT, AST, TG, CHOL, LDL and MDA, and SOD content significantly increased in the liver. The structure of hepatic lobules was clear, liver sinus returned to normal, and liver cell cords were arranged in neat rows. Cloudiness, swelling, inflammatory cell infiltration and spotty necrosis of liver cells were significantly reduced. Therefore, C-PC can significantly protect against ethanol-induced acute liver injury.     

大都市区的形成机制及其定界：以北京为例

源于欧美的大都市区,在中国具有特殊的形成机制和联系形式。对北京的研究表明,其形成主要由中心城市工业化的扩散和农村非农业化两种过程所决定,并据此提出了中国大都市区定界的初步方法。进一步研究还发现中国已经出现了都市连绵带。     

�й���½GPS����Ĺ��켰����ѧ��������Ԫ����

????????й?????????????????????????????????????????????????????????????????????????μ??й?????α? ?????GPS???????????????????????????????:??????????????????10???????й????????????????????????10??GPS?????????????????????;?????????????????????:??????????????????????????,??????????????????????????????????????,??????????????????????黡???????????????????????????,?????????????????????????????????????????????:1)?й?????????????????????????????????????????????????????????????????????????????;2)?Щ????????????????????????????????????й??????????????????     

南极数值天气预报应用与研究进展

多个业务化的全球预报模式和有限区域预报模式应用于南极地区,已经成为南极天气预报和南极气候诊断研究的主要工具.现今南极地区的数值天气预报模式在模拟南极大气环流和天气系统方面性能不够理想,原因是多方面的:南极天气气候的特殊性(包括边界层的参数化、中尺度气旋等)、模式对南极复杂地形的描述不够充分、由于缺乏观测资料而使得模式的...     

Methods for extraction of microorganism DNA from glacier surface snow

In order to thoroughly investigate the diversity of glacier microorganisms, four DNA extraction methods with different lysis patterns were tested and two screened methods (the Bosshard-Bano method and the Zhou method) were optimized for the most effective form of the filter membrane (cut vs. uncut), the DNA extraction method, and the precipitation method. The two optimized methods were then compared with the commercial Mo-Bio DNA extraction kit, and the results showed that the kit was generally suitable for extraction of microorganism DNA from glacier surface snow. Procedurally, it was found that a modified Bosshard- Bano method (i.e., cutting the filter membrane into pieces, using a specific lysis pattern [lysozyme (5 mg/mL)-protease K (1 mg/mL)-CTAB (1%)-SDS (1%)], performing the extraction only once by chloroform-isoamyl alcohol (24:1), and conducting DNA precipitation by pure ethanol) was also an effective and less expensive method for extraction of microorganism DNA from glacier surface snow.     

湖北省潮汐形变观测异常及干扰识别

对2003—2013年湖北省数字化定点形变潮汐观测中的突跳、阶变、震颤等异常的分析发现,气象因素对形变潮汐观测的影响复杂:1)不同气压场控制影响形变观测的异常形态不同,但响应频率一致;2)台风对形变观测的秒值和分钟值数据在1～4秒和2～4分钟较高频段均有响应;3)台址条件不同,降雨对形变观测产生的畸变影响不同。影响范围一般在0～全日波频段且存在较大的噪声;4)短时大气温度变化对形变观测有一定影响,会使曲线发生抖动或暂态波动,在64～128分钟和128～256分钟较低频段上有响应。水库冲沙、水库蓄水、土石开挖等环境荷载变化对分钟值观测曲线产生明显阶跃、抖动型实时畸变。人员进洞、施工、仪器标定检修等人为活动对观测曲线的影响可直接识别。     

干涸尾闾湖盆区泥漠地表磨蚀释尘特征

沙粒的表面磨蚀效应是地表产尘、释尘的重要机制,针对干湖盆泥漠地表开展磨蚀释尘实验研究,对理解干湖盆地表风蚀过程及盐碱尘暴形成机理具有重要意义。对采自西居延海干涸湖盆泥漠地表土样进行室内磨蚀模拟实验,研究了不同粒级（细、中、粗）沙粒不同落沙角度（30°,45°,60°）的磨蚀效应。结果表明：（1）泥漠地表磨蚀实验中能够产生明显释尘效应的沙粒粒级阈值为中沙（0.25 mm<M_d<0.50 mm）;（2）磨蚀粒径粒级相同时,磨蚀角度会对泥漠地表磨蚀释尘速率产生影响,磨蚀量的角度排序为60°>30°>45°,但同一粒级3种角度下的磨蚀释尘率差异不显著。（3）磨蚀角度为45°时,计算了泥漠地表的质量磨蚀率与能量磨蚀率,其中中沙为0.04 g·kg^-1、0.43 g·J^-1,粗沙为0.08 g·kg^-1、0.74 g·J^-1,极粗沙为0.26 g·kg^-1、2.54 g·J^-1;在磨蚀沙粒粒级倍增而磨蚀角度不变情况下,泥漠地表磨蚀释尘率与能量磨蚀率未发生正比例线性增长变化。     

Sequential city growth: Theory and evidence from the US

City growth patterns are attracting more attention in urban geography studies. This paper examines how cities develop and grow in the upper tail of size distribution in a large-scale economy based on a theoretical model under new economic geography framework and the empirical evidence from the US. The results show that cities grow in a sequential pattern. Cities with the best economic conditions are the first to grow fastest until they reach a critical size, then their growth rates slow down and the smaller cities farther down in the urban hierarchy become the fastest-growing ones in sequence. This paper also reveals three related features of urban system. First, the city size distribution evolves from low-level balanced to primate and finally high-level balanced pattern in an inverted U-shaped path. Second, there exist persistent discontinuities, or gaps, between city size classes. Third, city size in the upper tail exhibits conditional convergence characteristics. This paper could not only contribute to enhancing the understanding of urbanization process and city size distribution dynamics, but also be widely used in making effective policies and scientific urban planning.     

白令海峡治理的合作机制研究

近年来随着北极冰盖的融化,北极通航已成为可能,而白令海峡作为北极航道重要的出口/入口,其战略地位也将逐步显现并被各国关注。在讨论白令海峡的治理与合作时,首先要明确白令海峡是用于国际航行的海峡,而作为海峡沿岸国的美国和俄罗斯对于白令海峡的管控与合作将成为影响未来北极航行的重要因素。为同时保障海峡沿岸国与使用国的利益,可借鉴马六甲海峡的治理经验,在现有治理机制的基础上进一步深化海峡沿岸国与海峡使用国的合作机制。中国作为海峡使用国也有必要积极参与白令海峡的合作治理。     

基于贝叶斯层次时空模型的甘肃省土地利用程度演变分析

以甘肃省为例,在基于Google Earth Engine (GEE)平台实现1995年、2000年、2005年、2010年、2015年和2020年土地变化监测的基础上,利用贝叶斯层次时空模型(BHM)分析土地利用程度的时空变化特征。结果表明：① 研究期间内甘肃省土地利用程度呈增长趋势,其中1995―2000年和2010―2015年增长速度较明显;② 土地利用程度空间格局“东高西低”,热点区域主要分布在陇中、陇东和陇南地区;③ 土地利用程度局部变化呈现明显区域差异,整体表现为“东弱西强”,局部变化热点区域主要分布在河西地区;④ 影响土地利用程度变化的主要因素是经济规模和产业结构,其中经济因素影响程度最高。