四君子汤加减联合阿帕替尼治疗老年晚期胃癌脾胃气虚证30例

目的：观察四君子汤加减联合阿帕替尼治疗老年晚期胃癌脾胃气虚证患者的临床效果及不良反应情况。方法：将60例老年晚期胃癌脾胃气虚证患者随机分为治疗组和对照组,每组各30例。对照组口服阿帕替尼治疗,治疗组在对照组的基础上加服四君子汤加减治疗。观察2组的近期疗效、KPS评分,治疗组用药前后CEA、CA199、CA72-4水平变化,2组免疫功能及不良反应情况。结果：治疗组患者客观缓解率和疾病控制率分别为56.67%、93.33%,优于对照组的30.00%、66.67%,2组比较,差异有统计学意义（P<0.05）。2组患者KPS评分治疗前后组内比较及治疗后组间比较,差异均有统计学意义（P<0.05）。治疗组CEA、CA199、CA72-4水平治疗后较治疗前明显下降（P<0.01）。对照组CD4^{+、CD4+/CD8+水平治疗后较治疗前升高;治疗组CD3+、CD4+、CD4+/CD8+水平较治疗前升高,且治疗组CD3+、CD4+水平升高幅度优于对照组,差异均有统计学意义（P<0.05）。治疗组不良反应如白细胞减少、乏力、蛋白尿、血压升高等发生情况明显低于对照组,差异均有统计学意义（P<0.05）。结论：四君子汤加减联合阿帕替尼治疗老年晚期胃癌脾胃气虚证患者效果较单用阿帕替尼为优,可有效降低CEA、CA199、CA72-4水平,提高患者免疫功能,且不良反应发生率低,值得临床推广。}     

The local properties of supernova explosions and their host galaxies

We aim to understand the properties at the locations of supernova(SN) explosions in their host galaxies and compare with the global properties of these host galaxies. We use the integral field spectrograph(IFS) of Mapping Nearby Galaxies at Apache Point Observatory(MaNGA) to generate 2 D maps of the parameter properties for 11 SN host galaxies. The sample galaxies are analyzed one by one in detail in terms of their properties of velocity field, star formation rate, oxygen abundance, stellar mass, etc.This sample of SN host galaxies has redshifts around z~0.03, which is higher than those of previous related works. The higher redshift distribution allows us to obtain the properties of more distant SN host galaxies. Metallicity(gas-phase oxygen abundance) estimated from integrated spectra can represent the local metallicity at SN explosion sites with small bias. All the host galaxies in our sample are metal-rich galaxies(12+log(O/H) 8.5) except for NGC 6387, which means SNe may be more inclined to explode in metallicity-rich galaxies. There is a positive relation between global gas-phase oxygen abundance and the stellar mass of host galaxies. We also try to compare the differences of the host galaxies between SNe Ia and SNe II. In our sample, both SNe Ia and SNe II can explode in normal galaxies, but SNe II can also explode in an interacting or a merging system, in which star formation is occurring in the galaxy.     

QTL Detection for Albinism-Related Loci in Chinese Tongue Sole (<Emphasis Type="Italic">Cynoglossus semilaevis</Emphasis>)

The Chinese tongue sole (Cynoglossus semilaevis) is widely cultured in the coastal region of East Asia and has excellent economic value. However, the high albino rate of the breeding population has caused a significant loss to the aquaculture industry. To study the molecular mechanism of albinism, the present study used an albino Chinese tongue sole family to construct three simple sequence repeat (SSR) linkage groups, and draft a preliminary linkage map related to albinism. After albinism-related loci mapping, 18 albinism-related loci were detected under two models (containing 2407 genes) compared to the Chinese tongue sole genome. One of these loci, the tyrosinase related protein (tyrp2), which has been reported previously as an important gene regulating both eumelanin and phaeomelanin levels, was indicated to be the possible cause of albinism. Thirty-five Gene Ontology (GO) terms and 14 Kyoto Encyclopedia of Genes and Genome pathways were annotated via bioinformatic analyses. One GO term with protein tyrosine kinase activity, which contained 10 genes, was previously suggested to affect fish albinism. These results establish a foundation for further in-depth study of albinism in Chinese tongue sole.     

瓯江口海域春秋季鱼类多样性及群落结构研究

根据2013年5月(春)、2013年10月(秋)在温州瓯江口海域进行渔业资源定点拖网调查获得的鱼类数据,利用渔获率作为数量分布的指标,对瓯江口海域的鱼类生态类群和鱼类种类组成、优势种、物种数目空间分布及多样性和鱼类群落结构进行了分析。结果显示:两次调查共鉴定鱼类66种,隶属12目37科51属,其中暖温性鱼类29种,占44%,暖水性鱼类37种,占66%,种类季节间变化较为稳定,优势种季节更替明显,春季优势种有银鲳Pampus argenteus、花鲈Lateolabrax japonicus、日本鳀Engraulis japonicus、棕腹刺鲀Gastrophysus spadiceus 4种,而秋季为花鲈、斑鰶Konosirus punctatus、龙头鱼Harpodon nehereus 3种;种类数平面分布结果显示,种类数春季沿岸区域高,秋季岛礁区域高,生物多样性春季高于秋季;多样性指数与种类数平面分布结果相似,均为江口外部海域高于内部,近岸和岛礁处高于中部,地形、台湾暖流和瓯江淡水团对其分布影响较大;春、秋季鱼类群落结构差异不大,种级和属级之间具有相似性。     

尾流中悬浮拦截弹环境噪声特性研究

尾流自导鱼雷对水面舰艇构成严重威胁。 为了把悬浮拦截弹被动拦截方式从非尾流区域扩展到尾流区,拦截尾流自导鱼雷,需要研究尾流内噪声特点,分析出拦截弹在尾流区的环境噪声特性。 基于悬浮拦截弹对不同吨位舰船尾流噪声进行研究,结合高阶累积量从概率论的角度出发,计算了尾流噪声的斜度和峰度随尾流年龄的变化规律;噪声斜度判断噪声是否满足对称分布,峰度判断噪声是否为高斯信号。 将实测数据与仿真数据峰度和斜度进行比对,得出结论：舰船尾流噪声环境可以近似看作是高斯信号,服从对称分布,且该分布特性与舰船吨位不相关。     

石油深井地震观测中“井管突升,地面崩裂”异常机理及其社会影响对策研究

１９７９年以来,天津地区先后有９口石油深井出现了“井管突升,地面崩裂”异常现象,本文通过这９口井的基本情况,分布特点,异常类型等方面的分析,对这一现象产生的机理进行了研究;认为;这一现象的发生是由于地面局部沉降的结果,并对其进行数值模拟,力学解释,同时提出了安定社会的三项对策。     

东海污损生物群落研究 Ⅱ.数量组成和分布

东海表层板污损藻类月平均湿重为２１０．８ｇ／ｍ２。底层板污损动物的月平均湿重为４９４．５ｇ／ｍ２。以甲壳动物的数量占绝对优势,其次为腔肠动物,其余各类群占比例较小。不同类型海域污损藻类的月平均湿重为远岸区高于近岸区高于内湾区高于河口区。污损动物的月平均湿重为远岸区高于内湾区高于近岸区高于河口区。污损生物数量有明显的季节变化。藻类的季节变化大;污损动物以夏、秋数量最大,冬、春数量小     

松粉热模拟产物中饱和烃生物标志物分布

松粉和高岭土混合样品热模拟残渣氯仿抽提物和烃饱馏份中的生物标志物主要是正构烷烃系列化合物,其次是类异戊二烯烷烃、甾族系列、三环二萜烷和系列化合物,检测出少量量烷基环己烷系列,异构烷烃系列和类胡萝卜烷系列生物标志物。各类地球化学指标显示松粉热解排烃呈现１５０￣２５０℃和３００￣４００℃两个高峰期,前期生烃物质可能来地孢粉抽粉壁中的类脂物,后期主要来泊于分外壁中的孢粉素,后斯的排烃量大于前期。正构烷烷     

油田断裂封闭性研究

文中着重阐述了断裂封闭性的研究方法。定性研究以断裂的力学性质和断裂两侧岩性对置情况为重点,同时结合断裂几何学特征、断裂活动强度、断裂形成时期与油气成藏期匹配关系以及断裂与构造应力场关系分析方法。半定量-定量研究新引入排驱压力分析、油藏描述技术-断层封堵量计算和断层泥涂抹计算以及断层封闭性模糊综合评判等新技术,将断裂评判为不封闭、封闭较好和封闭最好三种类型。不封闭的断裂为油气运移的通道,封闭较好和封闭最好的断裂遮挡油气,聚集成藏。