基于生物信息学探讨骨质疏松症与2型糖尿病的关系

目的：基于生物信息学探讨骨质疏松症与 2 型糖尿病的关系。方法：通过基因表达汇编（GEO）数据库检索骨质疏松症和2型糖尿病的相关数据集,并筛选骨质疏松症-2型糖尿病共同差异表达基因,将数据导入STRING数据库找寻关键基因,以一个单细胞测序数据集作为检验集验证关键基因细胞层面的表达水平,对筛选结果进行基因本体（GO）功能及京都基因与基因组百科全书（KEGG）通路富集分析,并对关键靶点、相关中药进行频数统计及功效分类。结果：骨质疏松症与 2 型糖尿病相关通路集中在 ErbB信号通路、丝活化蛋白激酶（MAPK）信号通路、神经营养素信号通路、NOD样受体信号通路。频数统计结果显示,与骨质疏松症-2型糖尿病关键基因相关的中药有51味,以功效分类,可分为清热解毒药、止痛药、祛风药、补虚药、止呕药。结论：骨质疏松症和2型糖尿病都是复杂的代谢性疾病,涉及众多基因表达网络和信号通路。尽管两种疾病存在复杂的基因网络背景,但是分析结果表明两种疾病之间仍存在高度重合的差异基因表达和信号通路。这表明两种疾病的分子机制密切相关,可能存在共同调控的靶点,因此这些靶点可能成为药物同时干预两种疾病的治疗靶点。     

伶仃洋沉积动力特点的研究

位于珠江三角洲东侧的伶仃洋，因径流下泄与潮流进退的流向不一，使它各分流口门的出口水道都有主槽和支槽之分，即都有主干水道和分汊水道。陆架高盐海水入侵又使伶仃洋内沉积动力过程在空间分布上发生差异，如沉积物分布有粗－细－稍粗之分；而水体中的密度、速度差异，常常产生锋带，对水下地形的发展有不可忽视的影响。因而全面认识发生在伶仃洋内的沉积动力作用，对深水航道的选线极为重要。     

珠江口沉积物酸挥发性硫化物与重金属生物毒性的研究

研究了2003年10月采于珠江口5个站位的沉积物剖面酸挥发性硫化物(AVS)和同时提取的重金属(SEM:Pb,Zn,Cu,Cd,Ni)。其中,站位1、2位于中滩,其沉积物的AVS含量变化范围较小,为0.25—4.06μmol.g-1;站位3、4位于西滩,其沉积物的AVS含量变化范围较大,为0—26.09μmol.g-1。中滩和西滩沉积物的AVS含量均随深度增加。西滩表层沉积物的AVS含量接近于零,这可能与该水域较强的底层流和沉积物的再悬浮作用有关。站位5位于珠江口外侧,其表层沉积物的AVS含量相对较高,且垂向变化较小,可能是还原性沉积物间歇性再悬浮后重新沉积的结果。站位1、2和5沉积物中同时提取的重金属含量大体在0.95±0.2μmol.g-1范围内,随深度增加略呈下降趋势;而西滩沉积物重金属含量相对较高,为1.43—2.42μmol.g-1,且在一定深度范围内随深度增加呈明显下降的趋势,表明珠江口西滩沉积物中的重金属污染有加重的趋势。对AVS/SEM摩尔比值和单个金属的毒性效应研究显示,珠江口内尤其是西滩的表层沉积物存在重金属污染,对其中生活的底栖生物具有潜在的毒性效应。     

钢筋混凝土梁结构断裂损伤诊断方法

提出一种基于BP神经网络的结构破损诊断方法,该方法以结构破损前后柔度的变化作为破损诊断网络输入,为了解决由于系统响应样本数据空间分布不均匀对网络收敛速度及网络诊断影响问题,对网络训练样本采用广义空间格点进行了交换,模拟算例及应用实例均表明,本文方法能准确诊断结构破损位置与破坏程度,是一种有效的结构破损诊断方法.     

A New Pursuit Mode of Nonlinear Wave Surface

The numerical mode of nonlinear wave transformation based on both the Laplace equation for water field and the Bemoulli equation for water surface is a kind of time-domain boundary problem with initial conditions. And the basis for establishing the numerical mode of nonlinear wave in time domain is to trace the position of wave free surface and to calculale the instantaneous surface height and surface potential function. This paper firstly utilizes the ‘0-1‘ combined BEM to separate the boundary by means of discretization of Green‘ s integral equation based on the Laplace equation, then separates the free surface of wave with FEM and derives the FEM equation of wave surface that satisfies the nonlinear boundary conditions. By jointly solving the above BEM and FEM equations, the wave potential and surface height could be obtained with iteration in time domain. Thus a new kind of nonlinear numerical mode is established for calculating wave transformation. The wave test in the numerical wave tank shows that the numerical simulation with this mode is of high accuracy.     

基于雷达海冰图像互相关的冰漂流场测量

我国的渤海和黄海北部在每年冬季都出现不同程度的冰情,它直接影响结冰海区的石油平台、船舶以及港口等设施的正常作业,对海冰的观测与预报随着上述海区的开发利用越发显得重要,利用航海雷达连续准确地跟踪海冰漂移运动轨迹,是当今观测、调查、研究冰漂流移动规律的有效方法之一,我国的科研人员利用雷达成像技术对渤海的冰情进行了长期的雷达海冰观测、研究,在由雷达海冰图像对海冰的物理特征的识别、分类以及冰漂流场测量方面取得了一些进展[1-4]。     

中国鱼类名录ⅩⅢ——鲽形目、纯形目、海蛾鱼目、鮟鱇目

鲽形目3亚目8科51属142种。鲀形目2亚目9科57属143种。海蛾鱼目1科2属3种，鮟鱇目3亚目11科23属41种。     

Action of Cnoidal Waves on Vertical Walls

Based on the 2nd order cnoidal wave theory, the characters of shallow water standing waves and their action on vertical walls are studied in this paper. The theoretical expressions of the wave surface elevation in front of and the wave pressure on the vertical wall are obtained. In order to verify the theoretical results, model tests were made in the State Key Laboratory of Coastal and Offshore Engineering at DUT. For the wave surface elevation in front of the wall and the wave forces on the wall at the moment when the wave surface at the wall surface goes down to the bottom of the wave trough, the calculated results coincide quite well with the experimental results. For the wave forces on the wall at the moment when the wave surface at the wall surface goes up to the top of the wave crest, the theoretical expressions are modified by the experimental results. For the convenience of practical use, calculations are made for the wave conditions which usually occur in enginering practice by use of the inves     

The behaviour of 59Fe in marine microhabitat

Under the artificial condition the 59Fe morphology in sea water, its concentration in sediment and phytoplankton, its distribution and metabolism in tissue organs of marine animals were studied. The results showed that the morphology of 59Fe was in a particulate state in sea water. The adsorption rule of 59Fe by three kinds of sediments was similar. The concentration ability of 59Fe by phytoplankton was very strong. The critical concentration organs of S9Fe by marine animals were viscera. The gross radioactivity of 59Fe was mainly concentrated in protein. The concentration factor of 59Fe by DNA was the highest one. After excretion experiment, 59Fe of all the tissue organs was not detected. Small part of59Fe remained in the organic acid and protein state. There was a redistribution process in sediment for59Fe.     

VERIFICATION OF INTERNAL WAVES IN OFFSHORE AREAS BY MEANS OF CURRENT OBSERVATIONS

Based on the shear effect of internal wave currents in stratified fluid, the necessary condition for the possible existence of an internal wave and the sufficient condition under which there will be no internal wave are deduced starting from the continuity equation of incompressible fluid. The above two conditions are verified by the measured results from vertical current meter arraies at some observation stations in the Bohai Sea and the South Huanghai Sea. In the treatment of measured results, first of all, the tidal period components are separated from the measured currents by Fourier-analysis method, and then the internal wave currents of tidal period from the tidal period components in the light of some considerations. The analytical results of observed currents are well consistent with theoretical analysis. Furthermore, one can also deduce some features of internal waves therefrom. Consequently, it is concluded that the observation from a vertical current meter array is an important means to verif