甲壳动物JAK/STAT信号通路在免疫应答中的功能与调控机制

先天免疫是宿主抵抗病原感染的第一道防线,在病原的传播和疾病的发展过程中发挥重要的作用。甲壳动物属于无脊椎动物,仅具有先天免疫,而不具备适应性免疫,其主要依靠细胞免疫和体液免疫来实现免疫防御功能,抑制病原体增殖。JAK/STAT途径是调节无脊椎动物免疫反应的主要途径之一,本文主要从细胞因子受体(Dome)、JAK酪氨酸激酶(JAK)、信号传导及转录激活因子(STAT)、调节因子的结构、在宿主体内的表达及发挥的功能等来综述在养殖甲壳动物中JAK/STAT信号通路的研究现状。目前已在对虾、螯虾和蟹等近十种甲壳动物中报道了此通路的元件,而且各元件均具有保守的典型结构域,同类元件在不同种类甲壳生物中的结构有所差异,但是功能基本相似。这些元件均被证实通过调节JAK/STAT通路的信号转导来影响抗病能力。目前仅在凡纳滨对虾（Litopenaeus vannamei）中鉴定出JAK/STAT信号通路的所有元件,对其他甲壳动物中剩余元件的鉴定仍有必要,并且甲壳动物JAK/STAT信号通路对其他信号通路的影响还有待深入研究。通过本文希望能为该通路在甲壳动物中调控机制研究提供理论基础和参考。     

青海湖热力状况的模拟与未来情景之研究

运用基于湖泊热量收支与湍流扩散的湖泊热力学模型模拟了青海湖近３０年来湖水热力状况,内容包括湖泊水面温度,温度沿深度的垂直分布,冬季结冰与融冰的起迄时间,冰盖厚度;积雪深度与天数等。在此基础上,运用４个ＧＣＭｓ模型输出的ＣＯ２倍增情景下该地区的气候状况,评价了湖泊热力状况在未来的可能变化情况。     

2016年3月21日金塔县M_S 4.7地震强震动记录分析

2016年3月21日11时29分甘肃省酒泉市金塔县发生M_S 4.7地震,甘肃省强震动台网中心收集到5组三分向加速度记录,常规处理后得到15条零基线校正后的三分向峰值加速度(PGA),选取土层台基类型的62XID台站加速度记录(PGA数值最大)进行分析,绘制校正后的加速度、速度和位移时程曲线及加速度反应谱,为中国西部工程震害调查提供参考资料。     

Study of a smart platform based on backstepping control method

A structural model is significant for the verification of structural control algorithms. However, for nonlinear behavior, experiments are mostly destructive tests that are costly, and conducting repetitive structural experiments is difficult. Therefore, a repetitive structural vibration model is important for structural vibration control. In this study, a smart platform to realize different structural behaviors is developed based on the backstepping control algorithm. Lyapunov functions are used to derive the control law. Simulations show that the designed model can track the structural responses of different arbitrary linear structures very well. In addition, the proposed platform can track responses of different piecewise linear structures and desired models with various hysteresis very well. Numerical results verify the effectiveness of the proposed tracking controller through the backstepping method for the established platform.     

Frequency-dependent rupture process,stress change,and seismogenic mechanism of the 25 April 2015 Nepal Gorkha <Emphasis Type="Italic">M</Emphasis><Subscript>w</Subscript> 7.8 earthquake

On 25 April 2015, an M _w 7.8 earthquake occurred on the Main Himalaya Thrust fault with a dip angle of ~ 7° about 77 km northwest of Kathmandu, Nepal. This Nepal Gorkha event is the largest one on the Himalayan thrust belt since 1950. Here we use the compressive sensing method in the frequency domain to track the seismic radiation and rupture process of this event using teleseismic P waves recorded by array stations in North America. We also compute the distribution of static shear stress changes on the fault plane from a coseismic slip model. Our results indicate a dominant east-southeastward unilateral rupture process from the epicenter with an average rupture speed of ~3 km s^?1. Coseismic radiation of this earthquake shows clear frequency-dependent features. The lower frequency (0.05–0.3 Hz) radiation mainly originates from large coseismic slip regions with negative coseismic shear stress changes. In comparison, higher frequency (0.3–0.6 Hz) radiation appears to be from the down-dip part around the margin of large slip areas, which has been loaded and presents positive coseismic shear stress changes. We propose an asperity model to interpret this Nepal earthquake sequence and compare the frequency-dependent coseismic radiation with that in subduction zones. Such frequency-dependent radiation indicates the depth-varying frictional properties on the plate interface of the Nepal section in the main Himalaya thrust system, similar to previous findings in oceanic subduction zones. Our findings provide further evidence of the spatial correlation between changes of static stress status on the fault plane and the observed frequency-dependent coseismic radiation during large earthquakes. Our results show that the frequency-dependent coseismic radiation is not only found for megathrust earthquakes in the oceanic subduction environment, but also holds true for thrust events in the continental collision zone.     

Snowdrift effect on snow deposition: Insights from a comparison of a snow pit profile and meteorological observations in east Antarctica

A high-frequency and precise ultrasonic sounder was used to monitor precipitated/deposited and drift snow events over a 3-year period(17 January 2005 to 4 January 2008) at the Eagle automatic weather station site,inland Antarctica.Ion species and oxygen isotope ratios were also generated from a snow pit below the sensor.These accumulation and snowdrift events were used to examine the synchronism with seasonal variations of δ~(18)O and ion species,providing an opportunity to assess the snowdrift effect in typical Antarctic inland conditions.There were up to 1-year differences for this 3-year-long snow pit between the traditional dating method and ultrasonic records.This difference implies that in areas with low accumulation or high wind,the snowdrift effect can induce abnormal disturbances on snow deposition.The snowdrift effect should be seriously taken into account for high-resolution dating of ice cores and estimation of surface mass balance,especially when the morphology of most Antarctic inland areas is similar to that of the Eagle site.     

Origin and Evolution of Aquitard Porewater in the Western Coastal Plain of Bohai Bay,China

High‐salinity paleowater from low‐permeability aquitards in coastal areas can be a major threat to groundwater resources; however, such water has rarely been studied. The chemical and isotopic compositions of porewater extracted from a 200‐m‐thick Quaternary sedimentary sequence in the western coastal plain of Bohai Bay, China, were analyzed to investigate the salinity origin and chemical evolution of porewater in aquitards. Porewater samples derived at depths shallower than 32 m are characterized by Cl‐Na type saline water (total dissolved solids [TDS], 10.9–84.3 g/L), whereas those at depths greater than 32 m comprise Cl·SO₄‐Na type brackish water (TDS, 2.2–6.3 g/L). Saline porewater is interpreted as evaporated seawater prior to halite saturation, as evidenced by Cl‐Br relationships. Although substantial dilution of saline porewater with meteoric water is supported by a wider Cl^? range and δ²H‐δ¹⁸O covariance, the original marine waters were not completely flushed out. The deeper brackish porewater is determined to be a mixture of fresher porewater and brine groundwater and had a component of old brine of less than 10%, as indicated by a mixing model defined using δ²H and Cl^? tracers. Porewater δ²H‐δ¹⁸O relationships and negative deuterium excess ranging from ?25.9‰ to ?2.9‰ indicate the existence of an arid climate since Late Pleistocene in Tianjin Plain. The aquitard porewaters were chemically modified through water‐rock interactions due to the long residence time.     

地震前兆仪器管理系统建设

长期以来,对前兆台网仪器的管理缺乏系统性。为此,研发了前兆仪器管理系统。该系统实现了对前兆仪器从购买到淘汰整个生命周期的管理,其中包括安装、接入、运行、故障、停测、报废等,以及仪器故障维修流程的管理,其中包括故障登记、处理、维修、备机备件库等。基于这些信息,对仪器及故障维修情况进行综合统计分析,为管理决策提供信息支持。本文主要介绍了该系统设计的一些主要技术方面和系统实现的主要功能。     

城市水利工程对京杭大运河无锡段水位影响分析

根据京杭大运河无锡段历年河流水位与降水量的关联,结合城市水利工程,分析了京杭大运河无锡段水位变化规律。重点研究了2003年前后水位变化的形成机制,推求出水利工程和气候条件下水位的变化特点,总结了城市水利工程对京杭大运河流向产生的影响。为本地区研究城市水利工程影响下河流水位变化情况及防汛应用提供了数据支持。     

祁连山北部基岩河道宽度对构造和岩性的响应

活动造山带基岩河流地貌研究,目前已成为构造地貌学研究的前沿和热点。河道宽度形态的调整变化是基岩河流响应构造、岩性和气候等扰动的重要方式之一。通过研究祁连山北部地区6个重点流域基岩河道的宽度形态发现:河道宽度总体上呈现出东西向和南北向的变化特征,河道向下游增宽的速率,东段地区显著高于中段地区,低山带显著高于高山带;对比河道宽度的变化特征与构造抬升速率及岩性抗蚀性的变化,可以推断:在祁连山北部地区,基岩河道宽度响应构造抬升和岩性抗蚀性的变化进行了系统地调整,构造抬升控制了流域河道宽度变化的总体趋势,而岩性抗蚀性变化则导致了流域内部局部河段河道宽度的大幅波动。在祁连山北部地区开展的基岩河道宽度形态研究,为利用基岩河道形态研究造山带的构造变形奠定了基础,对于探索构造抬升背景下地貌的发育过程具有十分重要的意义。