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101.
102.
目的:基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制。方法:应用TCMSP和UniProt数据库平台查询青蛇方组方的有效活性成分及靶基因,与疾病靶基因取交集后构建蛋白质-蛋白质相互作用(PPI)网络;应用DAVID数据库,对潜在核心作用靶点基因进行基因本体(GO)功能、京都基因与基因组百科全书(KEGG)通路富集分析。利用分子对接原理论证青蛇方生物活性成分与核心靶点的分子结合能力。结果:筛选出青蛇方有效成分63种,作用靶点99个;主要有β-谷甾醇、2,4,7-三羟基-9,10-二氢菲、靛蓝素、豆甾醇、色氨酸等关键成分;转录因子AP-1(JUN)、肿瘤坏死因子(TNF)、原癌基因(RELA)、干扰素γ(IFNG)、转化生长因子-β1(TGF-β1)等核心基因。关键信号通路有癌症信号通路、恰加斯病通路、弓形体病通路、脂质和动脉粥样硬化通路等,分子对接结果显示活性成分与核心靶点基因结合能力较强。结论:青蛇方外用可以通过多种活性成分、多种通路有效抑制免疫炎症反应,促进免疫系统正常运行,从而达到治疗湿疹的目的。 相似文献
103.
传统认为中国南方的离子吸附型稀土矿床可划分为以“足洞式”为代表的重稀土型和以“河岭式”(或“花山式”)为代表的轻稀土型两种矿化类型。然而,近年来发现的许多矿床(如清溪、寨背和馒头山等)的赋矿风化壳中出现了轻稀土矿与重稀土矿并存现象,表现出特殊的“上轻下重”双层矿体结构。这指示了除重稀土型和轻稀土型之外,还存在着轻重稀土共生型的过渡类型。本研究通过对三种不同成矿类型的若干典型矿床系统对比,指出成矿类型的多样性与母岩性质密切相关,尤其是母岩的稀土元素地球化学和稀土载体矿物属性是制约成矿类型变化的关键因素。统计数据表明,从重稀土型→轻重稀土共生型→轻稀土型,成矿母岩的全岩稀土总量变化不大(ΣREY: 200×10-6~450×10-6→200×10-6~500×10-6→200×10-6~800×10-6),但轻重稀土配分值出现较显著的区间性差异(ΣLREE/ΣHREY: 02~1→1~5→2~10)。与之同时,母岩中能为离子相稀土提供物源且具有重稀土配分属性的稀土副矿物类型和数量明显减少,这与全岩稀土元素地球化学特征中重稀土分量占比的降低趋势也互相匹配。该结果指示,以往认为重稀土配分母岩形成重稀土矿床、轻稀土配分母岩形成轻稀土矿床的传统观点需要外延,即一部分具有低度轻稀土配分属性(1<ΣLREE/ΣHREY<5)且含有丰富易风化稀土副矿物的母岩还可能形成轻重稀土共生型矿床,该认识可为今后离子吸附型稀土矿床勘查工作提供新的找矿依据。 相似文献
104.
105.
Observations of two quiescent filaments show oscillatory variations in Doppler shift and central intensity of the He i 10830 Å line.The oscillatory periods range from about 5 to 15 min, with dominant periods of 5, 9, and 16 min. The 5-min period is also detected in the intensity variations, after correction for atmospheric effects. Doppler shifts precede intensity variations by about one period. The possibility that the oscillations are Alfvén waves is discussed.The Doppler signals of the filament form fibril-like structures. The fibrils are all inclined at an angle of about 25° to the long axis of the filament. The magnetic field has a similar orientation relative to the major direction of the filament, and the measured Doppler signals are apparently produced by motions along magnetic flux tubes threading the filament.The measured lifetimes of the small-scale fibrils of quiescent disk filaments are very likely a combined effect of intensity modulations and reshuffling of the structures. 相似文献
106.
新疆第三次荒漠化监测中的问题及其建议 总被引:4,自引:1,他引:4
回顾了新疆3次在荒漠化监测中所进行的荒漠化监测与评价指标体系的建立,也是新疆开展荒漠化监测的基础;介绍了以遥感与地理信息为主要技术的荒漠化监测评价的方法;阐述了新疆第三次荒漠化监测中存在的问题。指出目前新疆荒漠化评价存在的主要问题是评价指标的不确定性、评价指标体系的难操作性和遥感数据源选用的随机性,进而对上述问题的解决途径进行了讨论。 相似文献
107.
Study on the kinetics of iron oxide leaching by oxalic acid 总被引:2,自引:0,他引:2
Suong Oh Lee Tam Tran Yi Yong Park Seong Jun Kim Myong Jun Kim 《International Journal of Mineral Processing》2006,80(2-4):144-152
The presence of iron oxides in clay or silica raw materials is detrimental to the manufacturing of high quality ceramics. Although iron has been traditionally removed by physical mineral processing, acid washing has been tested as it is more effective, especially for extremely low iron (of less than 0.1% w/w). However, inorganic acids such as sulphuric or hydrochloric acids easily contaminate the clay products with SO42− and Cl−, and therefore should be avoided as much as possible. On the other hand, if oxalic acid is used, any acid left behind will be destroyed during the firing of the ceramic products. The characteristics of dissolution of iron oxides were therefore investigated in this study.The dissolution of iron oxides in oxalic acid was found to be very slow at temperatures within the range 25–60 °C, but its rate increases rapidly above 90 °C. The dissolution rate also increases with increasing oxalate concentration at the constant pH values set within the optimum range of pH2.5–3.0. At this optimum pH, the dissolution of fine pure hematite (Fe2O3) (105–140 μm) follows a diffusion-controlled shrinking core model. The rate expression expressed as 1 − (2 / 3)x − (1 − x)2 / 3 where x is a fraction of iron dissolution was found to be proportional to [oxalate]1.5.The addition of magnetite to the leach liquor at 10% w/w hematite was found to enhance the dissolution rate dramatically. Such addition of magnetite allows coarser hematite in the range 0.5–1.4 mm to be leached at a reasonable rate. 相似文献
108.
109.
Effect of polypropylene fibre and lime admixture on engineering properties of clayey soil 总被引:2,自引:0,他引:2
In order to reduce the brittleness of soil stabilized by lime only, a recent study of a newly proposed mixture of polypropylene fibre and lime for ground improvement is described and reported in the paper. To investigate and understand the influence of the mixture of polypropylene fibre and lime on the engineering properties of a clayey soil, nine groups of treated soil specimens were prepared and tested at three different percentages of fibre content (i.e. 0.05%, 0.15%, 0.25% by weight of the parent soil) and three different percentages of lime (i.e. 2%, 5%, 8% by weight of the parent soil). These treated specimens were subjected to unconfined compression, direct shear, swelling and shrinkage tests. Through scanning electron microscopy (SEM) analysis of the specimens after shearing, the improving mechanisms of polypropylene fibre and lime in the soil were discussed and the observed test results were explained. It was found that fibre content, lime content and curing duration had significant influence on the engineering properties of the fibre–lime treated soil. An increase in lime content resulted in an initial increase followed by a slight decrease in unconfined compressive strength, cohesion and angle of internal friction of the clayey soil. On the other hand, an increase in lime content led to a reduction of swelling and shrinkage potential. However, an increase in fibre content caused an increase in strength and shrinkage potential but brought on the reduction of swelling potential. An increase in curing duration improved the unconfined compressive strength and shear strength parameters of the stabilized soil significantly. Based on the SEM analysis, it was found that the presence of fibre contributed to physical interaction between fibre and soil whereas the use of lime produced chemical reaction between lime and soil and changed soil fabric significantly. 相似文献
110.
在综合分析黄衢高速公路K20 500~K21 000段地质及勘探资料的基础上,分析了外徐塘大桥桥位区的岩溶发育情况及其分布特征,并对本区岩溶发育成因进行了初步探讨。认为岩溶主要发育在河道内,发育程度一般,受构造控制。 相似文献