渤、黄海假潮的气象学成因

对渤、黄海14个主要海湾的原始验潮记录进行了分析，从中筛选出水位变化幅度大于或等于50cm的54个假潮个例，着重分析了伴随假潮过程的天气形势，把可能引发假潮的天气形势归纳为4种基本类型。分析结果显示：绝大多数（92％）引发假潮的天气个例都与锋面活动有关；所有个例中低层大气基本上都是弱静力稳定，且都具有较强的垂直风速切变。根据观测事实和稳定度理论分析认为，低层大气的弱静力稳定层结构以及由垂直风速切变引起的剪切不稳定性，是假潮气象学成因的一种必要条件和物理机制。     

Crustal Thinning of the Northern Continental Margin of the South China Sea

Magnetic data suggest that the distribution of the oceanic crust in the northern South China Sea (SCS) may extend to about 21 °N and 118.5 °E. To examine the crustal features of the corresponding continent–ocean transition zone, we have studied the crustal structures of the northern continental margin of the SCS. We have also performed gravity modeling by using a simple four-layer crustal model to understand the geometry of the Moho surface and the crustal thicknesses beneath this transition zone. In general, we can distinguish the crustal structures of the study area into the continental crust, the thinned continental crust, and the oceanic crust. However, some volcanic intrusions or extrusions exist. Our results indicate the existence of oceanic crust in the northernmost SCS as observed by magnetic data. Accordingly, we have moved the continent–ocean boundary (COB) in the northeastern SCS from about 19 °N and 119.5 °E to 21 °N and 118.5 °E. Morphologically, the new COB is located along the base of the continental slope. The southeastward thinning of the continental crust in the study area is prominent. The average value of crustal thinning factor of the thinned continental crust zone is about 1.3–1.5. In the study region, the Moho depths generally vary from ca. 28 km to ca. 12 km and the crustal thicknesses vary from ca. 24 km to ca. 6 km; a regional maximum exists around the Dongsha Island. Our gravity modeling has shown that the oceanic crust in the northern SCS is slightly thicker than normal oceanic crust. This situation could be ascribed to the post-spreading volcanism or underplating in this region.     

基于网络药理学探究补阳还五汤治疗颈椎病的作用机制

目的：基于网络药理学与分子对接技术分析补阳还五汤治疗颈椎病的作用机制。方法：使用TCMSP、化学专业数据库获取补阳还五汤的活性成分,并对潜在靶点进行预测及规范。分别从PharmGKB、DisGeNET、OMIM、GeneCards数据库中得到颈椎病疾病靶点,利用韦恩图获取补阳还五汤与颈椎病的交集靶点。通过CytoScape软件构建中药-活性成分-疾病靶点和蛋白质-蛋白质相互作用（PPI）网络,获得核心有效成分与关键靶点,利用David数据库对潜在靶点进行富集分析。最后运用AutoDock Vina软件对补阳还五汤核心有效成分与关键靶点进行分子对接验证。结果：共获得补阳还五汤治疗颈椎病的有效活性成分97个,包括槲皮素、山柰酚、黄芩素、木犀草素等;交集靶点64个,关键靶点有白细胞介素-6（IL-6）、肿瘤坏死因子（TNF）、丝氨酸/苏氨酸蛋白激酶1（AKT1）、白细胞介素-1B（IL-1B）等;主要涉及肿瘤坏死因子（TNF）、白细胞介素-17（IL-17）、磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（Akt）等信号通路,分子对接结果显示核心有效成分与关键靶点之间结合紧密,为补阳还五汤治疗颈椎病提供相应条件。结论：该研究在总体上预测了补阳还五汤治疗颈椎病的活性成分、靶点和信号通路,作用途径广泛,为下一步的临床应用提供参考及思路。     

碘－钒盐催化下合成的四溴邻苯二甲酸酐

报道一种新的有效催化剂－碘－钒盐和在一定条件下合成四溴邻苯二甲酸酐的方法。探讨催化剂的组成配比、用量、温度及废酸循环使用等因素对合成方法的影响。该催化剂的催化效果和常用的碘、碘－铁催化剂相同，适用于四溴邻苯二甲酸酐的合成。     

合浦珠母贝卵子电击脉冲参数的初步研究

运用电脉冲转基因仪对合浦珠母贝卵子进行电脉冲处理以优化电穿孔法转基因的电击参数。实验中调制百分比：100％；脉冲间隔：1．0s：电极距离：2mm；脉冲个数：5个，参数保持不变。用不同的电脉冲参数组合（脉冲电压100-400V、脉冲持续时间0．5～3．0ms、脉冲频率10～50kHz，共28个组合）对卵子电击，然后加入精子进行授精，统计各组受精率和孵化率，以受精率和孵化率达到50％以上为衡量指标。结果表明，合浦珠母贝卵子对低脉冲频率和高电压非常敏感，当频率低于20kHz或脉冲电压高于400V时对卵子损伤较大。脉冲持续时间对其影响不大，适应范围较宽。优化的转基因电击脉冲参教组合为：脉冲电压1.0kV／cm，脉冲持续时间20ms，脉冲频率50kHz，或者脉冲电压1．5kV／cm，脉冲持续时间1．5ms，脉冲频率50kHz。     

进入渤海的热带气旋路径特点分析

热带气旋是夏季影响渤海的灾害性天气系统之一。其影响路径主要有三类，各类路径在影响时前期中高纬500hPa高空环流形势及夏季西太平洋副热带高压特征指数有显著差异。     

Types and characters of sub-bottom acoustic reflection in eastern part of Bohai Sea

Ｈｉｇｈ－ｒｅｓｏｌｕｔｉｏｎｓｕｂ－ｂｏｔｔｏｍｐｒｏｆｉｌｅｒｈａｓｒｅｖｅｄｅｄｓｅｄｉｍｅｎｔａｌｓｔｒａｔａａｎｄｅｎｔｉｒｏｎｍｅｎｔｓｉｎｔｈｅｅｕｔｔｍｐ．ｏｆｔｈｅｌ３ｏｈａｉＳｅａｓｉｎｃｅｔｈｅｌｔａｔｅＰｌｅｉｓｔｏｃｅｎｅ．Ａｔｃｃｏｒｄｉｎｇｔｏｔｈｅｃｈａｒａｃｔｅｒｓｏｆａｃａｕｓｅｉｃｒｅｆｌｅｃｔｉｏｎａｎｄｓｅｉｓｍｉｃｔｓｔｒａｔｔｌｇｍｐｈｉｃｐｒｉｎｃｉ－ｐｌｅ，ｓｏｍｅｃｌｔ．ｉｆｉｃａｔｉｏｎｏｆｔｙｐｉｃａｌａｃｏｕｓｔｉｃｒｅｆｌｅｃｔｉｏｎｉｓｎｚａｄｅｏｕｔｔｎｄｗｉＵｂｅｆａｖｏｕｒａｂｌｅｆｏｒｉｎｔｅｒｐｒｅｔａｔｉｏｎａｎｄｒｅｃｏｇｎｂａｔｉｏｎｏｆａｏｏｕｓｔｉｃｐｒｏｆｉｌｅｓｉｎｔｈｉｓａｒｅａ     

南海晚第四纪浮游有孔虫类群变化所表征的古海洋学特征

通过对南海4个岩心的74个样品进行Q型因子分析,求得4个浮游有孔虫组合:亚热带-热带组合,温凉组合,热带易溶组合和亚热带组合。亚热带-热带组合为优势组合,它的发育状况反映了晚第四纪西太平洋热带海水对南海的影响程度,其因子载荷作为古海流特征的参数。温凉组合的发育与南海存在冷涡有关。利用转换函数FP-12E计算了南海南部表层古水温,冰期与间冰期的表层水温平均变化冬季为4.7℃和2.9℃,夏季为3.0℃和2.1℃,季节性温差冰期最大可达8.6℃,间冰期最大可达5.0℃,均比太平洋同一纬度海区的大。冬季表层古水温波动比夏季的大。全新世的表层水温呈上升趋势,但在NS86-43柱中有一变冷现象,这可能和the younger Younger Dryas有关。     

茶皂素对几种鱼类和对虾的毒性研究

本研究以茶皂素类作为“清池剂”,试图解决对虾养殖的基础和应用技术问题。试验结果表明:对虾对茶皂素和油茶皂素有较高的耐受力;茶皂素与油茶皂素均具鱼毒活性,油茶皂素则较强。鱼种不同,中毒反应也略有差异;两种茶皂素的鱼毒速度快,在致死浓度时16h内出现中毒死亡,毒性降解也快,浓度为5×10~(-6)时40h后不再引起鱼类中毒。     

Investigation of the hydrate reservoir production under different depressurization modes

Abstract

Large reserves of natural gas hydrates exist, and the depressurization method has the greatest potential for gas hydrate reservoir recovery. Currently, the most commonly adopted depressurization simulation method is a constant bottom-hole pressure production scheme. This study proposes a new depressurization mode with decreasing bottom-hole pressure. The production characteristic was numerically investigated using this method. The results show the following: (1) As the depressurization exponent (n) decreases, the development effect improves, and production indexes including cumulative gas production/dissociation and gas-water ratio increase. However, the reservoir energy consumption is higher and the hydrate reformation is more severe. (2) Compared to the proposed depressurization mode, the hydrate production index of the constant bottom-hole pressure production (n?=?0) is better. However, the hydrate reservoir energy consumption is higher and the hydrate reformation is more severe using constant bottom-hole pressure production. (3) To achieve a balance between production and reservoir energy consumption during depressurization production, the bottom-hole pressure should be controlled by selecting a suitable depressurization exponent between n_min and n_max, which can be determined through numerical simulations.