Pharmacokinetics and acetylation of sulfamethoxazole in turbot <Emphasis Type="Italic">Scophthalmus maximus</Emphasis> after intravascular administration

The pharmacokinetic profiles and sulfamethoxazole (SMX) acetylation process in turbot reared at 18°C were investigated. Either SMX (parent drug) or its acetylized metabolite, N₄-acetylsulfamethoxazole (AcSMX), was administered intravascularly to turbot at a dosage of 50 mg/kg BW. Serum concentrations of the parent drug and its metabolite were both measured by HPLC, and the changes in concentration over time were analyzed in two- and non-compartment models because SMX treatment produced multiple peaks. The results demonstrated that the elimination half-life of the parent drugs, SMX and AcSMX, were 159.2 and 5.9 h, respectively. The apparent volume of distribution was 0.2 and 0.8 L/kg, and the clearance was 0.038 and 0.222 L/(h·kg), for SMX and AcSMX, respectively. SMX acetylation in turbot was 2.8%, and the deacetylation of AcSMX was 0.2%. These findings may be useful in optimizing SMX dosage regimens in turbot aquaculture.     

吉林红旗岭镁铁-超镁铁质岩体地球化学特征及其岩石成因意义

红旗岭铜镍硫化物矿床位于兴-蒙造山带东部。矿区出露30多个镁铁-超镁铁质侵入体,主要由橄榄岩、辉石岩和辉(苏)长岩组成。本文通过对红旗岭含矿镁铁-超镁铁质岩体的主、微量及铂族元素(PGE)的研究,探讨了红旗岭岩体成矿母岩浆性质、PGE亏损的原因以及岩体形成的构造环境。全岩主、微量元素地球化学分析表明,红旗岭岩体具有高MgO(平均28.75%)、低TiO2(平均0.44%),富集轻稀土元素(LREE)、亏损高场强元素(HFSE),极低ΣPGE(平均2.08×10~(-9))和高Cu/Pd(平均2916×10~3)的特征。岩石样品显示相似的微量和PGE配分模式,表明其来源于相同的岩浆源区。根据橄榄石-熔体平衡及质量平衡原理估算出红旗岭母岩浆为高镁玄武质岩浆(MgO=10.74%、FeO=7.78%)。红旗岭母岩浆在早期演化过程中发生硫化物熔离作用导致了红旗岭含矿岩体PGE的极度亏损。结合中亚造山带东段构造演化历史,本文认为红旗岭岩体形成于晚三叠世碰撞后伸展环境,矿床的形成受到了古亚洲洋俯冲结束后板片断离的影响。     

山西保德上二叠统孙家沟组中发现锯齿龙类集群埋藏化石

正1研究目的(Objective)晚二叠末期地球生物大灭绝事件已被众多地质学家所证实。近年来,随着全球海相P-T界线层型剖面和"金钉子"(GSSP)在中国浙江煤山确立,生物地层学的研究热点又转向陆相P-T界线研究。地处华北地区的山西,陆相二叠系、三叠系齐全,是该时期众多组名的命名地点,且各地层中保存有各门类动、植物化石,有望成为陆相P-T界线研究的理想地区。有观点认为,晚二叠世,由于全球气温急剧升高,植物大量死亡,陆生脊椎动物由于不适     

帕米尔高原东北缘活动构造对塔什库尔干盆地地热控制作用

帕米尔东北缘位于青藏高原西北部,是新构造运动最强烈的地区之一。受控于公格尔拉张断裂作用的塔什库尔干盆地,活动构造强烈,高的大地热流值和丰富的地下水,使其具备地热资源形成的地质构造和水文条件。基于塔什库尔干盆地北部的曲曼地区地质构造、湖相地层年代学调查研究,该地区发育晚更新世的NNE向f_1和f_2正断层以及第四纪沉积物之下存在隐伏的近EW向的断层f_3。这3条断层是塔什库尔干断裂在不同构造演化时期形成的次级断层。结合EH-4电磁成像和钻孔及抽水试验等资料表明NNE向f_1和f_2正断层是地热系统的导水通道,而近EW向f_3断层为导热通道。该地区地热模式是大地热流为热源-地下水深循环逐渐加热-构造控水和控热。     

钻井利器的故事之“铝合金钻杆”

地球科学的发展对地球深部数据的依赖程度越来越高,作为“入地”重要手段的科学超深井工程是研究深部地质学的重要方法,被誉为是“伸入地壳的望远镜”。与钢钻杆相比,铝合金钻杆以其独特的优越性(质量轻、比强度高、钻进深度深、所需能耗少),已成为难进入地区、大位移井、超深井等钻柱设计的优选方案。本文从科普的角度介绍了钻柱与钻杆的区别、钻柱的使用极限长度、铝合金钻杆的技术优势及其现存的不足之处,以此提高对铝合金钻杆的认识,促进铝合金钻杆的研究和发展。     

煤层气U型对接井施工关键技术探讨

煤层气地面排采先后经历了常规直井、常规定向井、U型井以及羽状分支井等阶段,其中U型井具有同步排采,占地少、最大限度沟通煤层裂隙等优点而逐渐成为当今煤层气地面排采的新宠。以YQ01井组为例,对U型对接井施工中难点问题进行梳理,提出了各主要施工阶段需要注意事项及技术措施,解决了井眼轨迹控制难、复杂情况高发、水平井与直井连通精度高等问题。节省了钻井成本,为后续煤层气U型对接井施工提供了技术借鉴。     

Occurrence and conceptual sedimentary model of Cambrian gypsum-bearing evaporites in the Sichuan Basin,SW China

During the Cambrian, gypsum-bearing evaporites formed in the Sichuan Basin, SW China. These rocks are important for oil and gas sealing, but details of their distribution and origin are not well established. This study examines the regional distribution and origin of the gypsum-bearing evaporites using a comprehensive analysis of drilling data from 34 wells, 5 measured cross-sections in the basin and surrounding area, and 96 maps of area-survey data. Results show that in the stratigraphic succession, the gypsum-bearing evaporites occur mainly in the Lower Cambrian Longwangmiao Formation, the Middle Cambrian Douposi Formation, and the Middle-Upper Cambrian Xixiangchi Group. Geographically, the rocks are found mainly in the southeastern part of the basin, and the distribution of deposits shows an overall SW-NE trend. The sedimentary environments for evaporite formation were evaporative lagoon and inter-platform basin in a platform setting. Gypsum was generated by the underwater concentration of sea water in a strongly evaporative environment. Both an evaporative restricted platform and a mixeddeposition restricted platform model appear to be applicable to the development of gypsum in the Sichuan Basin. The gypsum-bearing evaporites with the best sealing capacity are located mostly in the southeastern part of the basin. These constraints can be applied directly to regional exploration, and have implications for the regional paleogeography and paleoclimate.