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We studied interactions of nitromusk compounds musk ketone and musk xylene and polycyclic musks Galaxolide trade mark (HHCB), Celestolide trade mark (ADBI), Tetralide trade mark (AHTN), and Traseolide trade mark (AITI) with multixenobiotic resistance (mxr) transporters in gill tissue of the marine mussel Mytilus californianus (Conrad, 1837). A competitive substrate transport test with rhodamine B was used to assay modulation of transport activity by musks. All tested musks inhibited the transport activity in the low microm range as indicated by increased accumulation of rhodamine B in the tissue. Compared to known substrates of mxr transporters, the effective concentration range was similar to quinidine and about 100 times higher than verapamil. Musk ketone and musk xylene also inhibited efflux of rhodamine B from gill tissue which was loaded with the dye and subsequently incubated with these compounds. Synthetic musk compounds are persistent environmental pollutants in aquatic environments with a high potential to bioaccumulate. As potent inhibitors of mxr transporters they may also play a role as chemosensitizers that enable toxic mxr substrates to accumulate in cells of aquatic organisms. 相似文献
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In this study male largemouth bass (LMB) were exposed to the naturally occurring androgens, dihydrotestosterone (DHT) or 11-ketotestosterone (11-KT) in order to identify genes that are differentially regulated by these steroid hormones. Using subtractive hybridization on livers of fish treated with DHT against vehicle control, many novel LMB genes were cloned. These genes were added to our gene library and arrayed. Six genes were up-regulated and five were down-regulated by both androgens. But, each androgen also regulated specific genes. One gene that was identified as a potential androgen marker was spermidine-spermine-N(1)-acetyltransferase that was up-regulated by both androgens. Determining which genes are responsive to natural androgens will help to identify biochemical pathways that are impacted. 相似文献
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Regoli F Gorbi S Frenzilli G Nigro M Corsi I Focardi S Winston GW 《Marine environmental research》2002,54(3-5):419-423
An integrate approach will be discussed for investigations on oxidative stress in xenobiotic toxicity. While the analysis of individual antioxidants is useful for their sensitivity and to understand the mode of action of a stressor, the integration with the analysis of the total antioxidant capacity provides a more holistic assessment of the overall biological significance of such variations. TOSC has a greater predictive value on the health condition of the organisms and allows to discriminate the different role of specific ROS in oxidative stress syndrome. 相似文献
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Trends in emigration from Ireland over time are reviewed. "During the eighteenth and nineteenth centuries overseas migration to the United States and seasonal harvest migration to Britain were the main types of movement, but over the past 100 years the Irish have developed a special affinity for settling in British towns. Although the outflow was halted for a time during the 1970s, when return migration took over, the 1980s have seen a renewal of the exodus. This time, however, the character of the flow has changed from predominantly low-skill construction and factory workers to embrace better-educated emigrants, including many graduates. This shift reflects Ireland's changing position in the international market for labour." 相似文献
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S.I. Sherman E.A.Gorbunova 《地学前缘》2008,15(3):337-347
已有的地质和地球物理方法无法对年、月、旬等现今时间尺度上的断层活动变化进行有效预测。运用基于地震活动定量指数运算程序的地理信息技术可以解决这个问题。这种方法被应用于贝加尔裂谷系(BRS)及邻区的研究当中。研究发现,断层活动变化发生在以几年为周期的时间尺度上,这无法用区域应力场的变化进行合理解释。沿着穿越贝加尔裂谷系的剖面编制了活动断层图以及地震活动定量指数曲线。提出的这种方法可以根据地震活动定量指数对活动断层进行仔细的分类,从而为解决地震中期预报相关问题开辟了重要途径。这种方法还被用来研究断层现今活动的时空变化和形成机制。研究发现,在实时尺度上断层活动具有高频发生的特征,这种现象可能是由于脆性岩石圈板内和块体内部运动产生的慢变形波的干扰导致的。利用变形波的通过速度可以对活动断层进行分组,各组具有不同的地质和地球物理特征参数,同时还可以对变形波波前的方向以及某一区域内主要断层在实时间隔内(地质上的瞬间)的活动情况进行预测。 相似文献