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71.
The pharmacokinetic profiles and sulfamethoxazole (SMX) acetylation process in turbot reared at 18°C were investigated. Either SMX (parent drug) or its acetylized metabolite, N4-acetylsulfamethoxazole (AcSMX), was administered intravascularly to turbot at a dosage of 50 mg/kg BW. Serum concentrations of the parent drug and its metabolite were both measured by HPLC, and the changes in concentration over time were analyzed in two- and non-compartment models because SMX treatment produced multiple peaks. The results demonstrated that the elimination half-life of the parent drugs, SMX and AcSMX, were 159.2 and 5.9 h, respectively. The apparent volume of distribution was 0.2 and 0.8 L/kg, and the clearance was 0.038 and 0.222 L/(h·kg), for SMX and AcSMX, respectively. SMX acetylation in turbot was 2.8%, and the deacetylation of AcSMX was 0.2%. These findings may be useful in optimizing SMX dosage regimens in turbot aquaculture. 相似文献
72.
73.
Kyung-Il Chang Nelson G. Hogg Moon-Sik Suk Sang-Kyung Byun Young-Gyu Kim Kuh Kim 《Deep Sea Research Part I: Oceanographic Research Papers》2002,49(12)
The Ulleung Basin is one of three deep basins that are contained within the East/Japan Sea. Current meter moorings have been maintained in this basin beginning in 1996. The data from these moorings are used to investigate the mean circulation pattern, variability of deep flows, and volume transports of major water masses in the Ulleung Basin with supporting hydrographic data and help from a high-resolution numerical model. The bottom water within the Ulleung Basin, which must enter through a constricted passage from the north, is found to circulate cyclonically—a pattern that seems prevalent throughout the East Sea. A strong current of about 6 cms−1 on average flows southward over the continental slope off the Korean coast underlying the northward East Korean Warm Current as part of the mean abyssal cyclonic circulation. Volume transports of the northward East Korean Warm Current, and southward flowing East Sea Intermediate Water and East Sea Proper Water are estimated to be 1.4 Sv (1 Sv=10−6 m3 s−1), 0.8 Sv, and 3.0–4.0 Sv, respectively. Deep flow variability involves a wide range of time scales with no apparent seasonal variations, whereas the deep currents in the northern East Sea are known to be strongly seasonal. 相似文献
74.
利用泥蚶(Tegillarca granosa)铁蛋白原核表达工程菌获得的重组铁蛋白,通过圆二色光谱分析蛋白二级结构,扫描电镜和电感耦合等离子质谱研究重组铁蛋白富集Fe~(2+)、Mn~(2+)、Cd~(2+)、Cr~(3+)、Hg~(2+)、Pb~(2+)和As~(3+)等7种重金属离子的特性,同时探索利用重组铁蛋白修饰丝网印刷电极,设计和制备重组铁蛋白检测Pb~(2+)和Cd~(2+)浓度的电化学生物传感器。结果表明复性成功的铁蛋白多为完整的?-螺旋结构,而复性不成功的蛋白聚集体则多为无规卷曲。重组铁蛋白的直径和形态与富集的离子种类有关。泥蚶铁蛋白对单一金属离子Fe~(2+)和Mn~(2+)的富集凸显优势。对两种混合金属离子的富集大多表现为竞争关系。但重组铁蛋白对Hg~(2+)和As~(3+)混合组的富集量明显高于单一金属离子组的富集量,对Hg~(2+)和As~(3+)混合组的富集表现出协同促进作用。重组铁蛋白传感器对Pb~(2+)和Cd~(2+)溶液的最低检测限为10μg/L。 相似文献
75.
Young-Ok Kim Eun Jin Yang Jung-Hoon Kang Kyoungsoon Shin Man Chang Cheol Soo Myung 《Ocean Science Journal》2007,42(1):9-17
The summer distributions of planktonic microbial communities (heterotrophic and phtosynthetic bacteria, phtosynthetic and
heterotrophic nanoflagellates, ciliate plankton, and microphytoplankton) were compared between inner and outer areas of Lake
Sihwa, divided by an artificial breakwater, located on the western coast of Korea, in September 2003. The semienclosed, inner
area was characterized by hyposaline surface water (<17 psu), and by low concentrations of dissolved oxygen (avg. 0.4 mg L1) and high concentrations of inorganic nutrients (nitrogenous nutrients >36 μM, phosphate <4 μM) in the bottom layer. Higher
densities of heterotrophic bacteria and nanoflagellates also occurred in the inner area than did in the outer area, while
microphytoplankton (mainly diatoms) occurred abundantly in the outer area. A tiny tintinnid ciliate, Tintinnopsis nana, bloomed
into more than 106 cells L1 at the surface layer of the inner area, while its abundance was much lower (103-104 cells L1) in the outer area of the breakwater. Ciliate abundance was highly correlated with heterotrophic bacteria (r = 0.886, p <
0.001) and heterotrophic flagellates (r = 0.962, p < 0.001), indicating that rich food availability may have led to theT. nana bloom. These results suggest that the breakwater causes the eutrophic environment in artificial lakes with limited flushing
of enriched water and develops into abundant bacteria, nanoflagellates, and ciliates. 相似文献
76.
对太平洋500hPa候高度场和距平场进行了主成分分析,得出反映500hPa候高度特征的典型场。指出候高度场的第1特征向量的空间型是季节变化的主要型,它可解释总方差的74.5%,候高度场的其余特征向量与距平场的特征向量是按顺序的对应相似。这些典型场可以很好地描述北太平洋的大气环流特征。距平场的第1特征向量空间型清楚地反映了与厄尔·尼诺现象有关的环流型。 相似文献
77.
To ascertain the importance of sputtering by solar wind ions on the formation of a sodium exosphere around Mercury and the Moon, we have irradiated with 4 keV He ions, the Na bearing tectosilicates: albite, labradorite, and anorthoclase, as well as adsorbed Na layers deposited on albite and on olivine (a neosilicate that does not contain Na). Sodium at the surface and near surface (<40 Å) was quantified with X-ray photoelectron spectroscopy before and after each irradiation to determine the depletion cross section. We measured a cross section for sputtering of Na adsorbed on mineral surfaces, σs ≈ 1 × 10?15 cm2 atom?1. In addition, mass spectrometric analyses of the sputtered flux show that a large fraction of the Na is sputtered as ions rather than as neutral atoms. These results have strong implications for modeling the sodium population within the mercurian and the lunar exospheres. 相似文献
78.
Bathymetry enhancement by altimetry-derived gravity anomalies in the East Sea (Sea of Japan) 总被引:1,自引:0,他引:1
Kwang Bae Kim Yu-Shen Hsiao Jeong Woo Kim Bang Yong Lee Yi Kyun Kwon Chang Hwan Kim 《Marine Geophysical Researches》2010,31(4):285-298
The gravity-geologic method (GGM) was used to enhance the bathymetry of the East Sea (Sea of Japan) with satellite altimetry-derived
free-air gravity anomalies and shipborne depth measurements. By comparison with the bathymetry model of Smith and Sandwell’s
(SAS) approach (1994), GGM was found to have an advantage with short wavelength (≤12 km) components, while SAS better predicts
longer wavelength (≥25 km) components, despite its dependency on density contrast. To mitigate this limitation, a tuning density
contrast of 10.25 g/cm3 between seawater and the seafloor was primarily estimated by the downward continuation method and then validated by the check
points method with GGM. Similarly, SAS is limited by the “A” value in low-pass part of the Wiener filter, which defines the effective range of the wavelength components on bathymetry.
As a final result, we present an enhanced GGM bathymetry model by integrating all available data. 相似文献
79.
A moving particle image velocimetry (PIV) system was successfully developed and used in a large towing tank for ship model tests to observe velocity fields near ship models. The experimental method involved adjustable optical devices for various test conditions and a special particle-seeding device. The streamwise and cross-streamwise flow fields of a yacht model and a tanker model were measured. Ship type, bottom shape, and towing speed were found to be the causes of problems affecting optical access and image quality. Possible solutions, deeper optical ducts, dark painting color, and pre-processed analysis method, were proposed and discussed. 相似文献
80.
1 .IntroductionEvery year ,Taiwanis subjectedtotwo or three typhoonintrusions in average which always causedisasters . Most of the disasters which occur around the coastal zone are due to seabed instability andcoastal structure destruction caused bytyphoo… 相似文献