卫矛醇对C6胶质瘤细胞体外抗癌活性及机制探讨

目的:研究卫矛醇对C6胶质瘤细胞株的体外增殖及凋亡的影响。方法：将C6大鼠胶质瘤细胞随机分为对照组、卫矛醇干预组、卫矛醇+雷帕霉素组、卫矛醇+3-MA组,各组予不同药物孵育,采用MTT法检测卫矛醇对C6细胞的体外增殖抑制率,筛选出抑制率相对较高且生长状态良好的细胞;应用Hoechest 33342染色透射电镜观察细胞凋亡亚显微结构的改变,采用免疫荧光和Western Blot技术检测与凋亡和自噬相关蛋白的表达水平。结果:卫矛醇对C6胶质瘤细胞增殖有明显的抑制作用,并呈现出良好的浓度-效应相关性,与对照组比较,随着浓度的增加,细胞的增殖抑制率上升(P＜0.01);Hoechst染色结果显示,与对照组相比,共同孵育卫矛醇24 h后的C6细胞出现明显的核固缩现象,证明有大量的细胞出现凋亡;Western Blot结果显示,与对照组相比,促凋亡基因Bax表达上调,抗凋亡基因Bcl-2表达下调。结论:卫矛醇能够抑制C6细胞的增殖,并诱导其凋亡,其作用机制可能与上调Bax、下调Bcl-2有关。     

虚拟现实技术在矿物数字博物馆中的应用

详细介绍基于照片的虚拟现实技术在矿物数字博物馆中的实现方法和应用,并对VRML与基于照片的虚拟现实技术进行分析研究,进而对两种实现方法的发展方向和应用前景提出见解。     

Sm-Nd ISOTOPIC AGE OF LAMPROPHYRES IN THE GEZHEN GOLD-BEARING SHEAR ZONE ON HAINAN ISLAND AND ITS GEOLOGICAL IMPLICATIONS

Sm-Nd isotopic compositions of eight lamprophyre samples, which come from the Gezhen gold-bearing shear zone on western Hainan Island, are measured. The Sm-Nd isochron age is 495.98±13.14 Ma, (143Nd/144Nd) 0=0.512094, εNd(t) ranges from +1.80 to +2.00 and TDM from 982 Ma to 1196 Ma (average: 1060 Ma). The authors point out that the whole-rock Sm-Nd isochron age (495.98 ± 13.14 Ma) really represents the petrogenetic age of lamprophyre and the time of magmatism during subsequent subduction.     

An oases dynamics model and its application in the Manas oasis

This study applies theories of systems and system dynamics to ecological economic systems in the oasis environment, with the intention of finding the basic characteristics of the oasis environment and its feedback structures. This study explores the inner mechanisms of economic development in the oasis environment and its relationship to policy variables. This model is applied to economic development in the Manas oasis of the Xinjiang Uygur Autonomous Region of China. System dynamics method starts from studying feedback structure within the system study and then searches for the best solution through identifying the right "policy point" and through model simulation in the computer. It embodies the cream of "systems cybernetics theory". This study is justified because the nature of the oasis system and the simulation results are scientifically sound and practically feasible.     

衡阳市生态环境现状及其改善对策

资源的不合理开发利用导致衡阳生态环境严重恶化。加强生态环境保护与建设对衡阳乃至湖南的可持续发展具有重要的意义。在分析衡阳市资源开发存在问题及其主要原因的基础上j探讨了在资源开发中建立可持续发展的良性生态环境的途径和措施，指出了要发展生态产业、开展生态环境的保护和建设，必须大力实施生态农业、生态林业、生态能源、生态旅游等生态经济工程，从而为衡阳市经济建设莫定坚实的生态可持续发展基础。     

论桩基施工中流砂现象处理

地下水流动对土体产生渗透力；当渗透力大于土体的抗剪强度，土体破坏，也就是当施工造成地下水水力坡度超过砂层的临界水力坡度即产生流砂现象．运用水文地质工程地质学方面的原理其处理方法有两类：—是莫尔一库仑法：即c法和φ法；二是临界水力坡度法(Ic法)．     

盐渍土与分散性针孔试验影响

通过具体实例,研究了新疆氯盐渍、硫酸盐渍土对针孔试验的影响,认为氯盐渍土因其胶结作用,随着盐量的增加,土样孔径大小、流量变化不大。硫酸盐渍土因其膨胀性,随着盐量的增加,土样孔径、流量减小,对土样的冲蚀破坏作用而不相同。     

洪家渡水电站左坝肩高边坡稳定及加固措施研究

贵州洪家渡水电站左坝肩高边坡开挖高度310 m,采用弹塑性有限元数值模拟方法对左坝肩高边坡施工期岩体应力应变状态进行分析研究,并结合现场变形观测资料对计算结果进行验证,从而对左坝肩高边坡的稳定性进行评价并提出相应的加固措施。     

基于复模态的有限元模型修正算法

针对地下结构地震响应分析中无限地基辐射阻尼问题，引入复模态情况下的具有非简化的堆积阻尼矩阵的阻尼模型，并针对具有集中质量阵的阻尼模型提出了合并与质量有关的阻尼和堆积阻尼的思想，并据此提出了一种修正此类有限元模型的两步法，首先从复模态参数中提取实模态参数，采用基于模态残余力的识别算法修正刚度矩阵，然后根据复模态参数和已得的刚度矩阵来识别阻尼模型中的刚度参与系数和质量阻尼堆积阻尼联合矩阵。     

EFFECTS OF THREE KINDS OF PHYSICAL PROCESSES ON TYPHOON INTENSITY*

This paper designs three quasi-geostrophic barotropic models with a radial/horizontal grid length being 2 kin,one in the polar coordinates,one on a stationary typhoon circulation condition and another on a non-stationary typhoon circulation condition in the Cartesian coordinates,to investigate the effects of azimuthal and radial linear advections,and nonlinear advection on the inward propagation of mesoscale vorticity and the changes of typhoon intensity.Results show that the azimuthal linear advection may result in the formation of spiral vorticity bands;the radial linear advection in a certain parameter set is able to transfer vorticity inwards,leading to a slight enhancement of typhoon;the nonlinear advection of perturbation vorticity on a stationary typhoon circulation condition may transfer more vorticities inwards,thus resulting in a distinct enhancement of typhoon;and the nonlinear advection on a non-stationary typhoon circulation condition possesses duality,i.e.on the one hand,the advection increases the vorticity of inward propagation,thus favorable to the intensification of typhoon,and on the other hand,in the inward propagation process of vorticity the originally concentric and axisymmetric structure of typhoon basic flow is damaged,and a complex flow pattern forms,which in turn tends to weaken the circulation of typhoon.At last the paper discusses the possible applications of those results in typhoon intensity prediction.