Antithrombotic effects of bromophenol, an alga-derived thrombin inhibitor

Thrombin, the ultimate proteinase of the coagulation cascade, is an attractive target for the treatment of a variety of cardiovascular diseases. A bromophenol derivative named (+)-3-(2,3-dibromo-4, 5-dihydroxy-phenyl)-4-bromo-5,6-dihydroxy-1,3-dihydroiso-benzofuran 1, isolated from the brown alga Leathesia nana exhibited significant thrombin inhibitory activity. In this study, we investigated the inhibition of human thrombin in vitro with this bromophenol derivative, and its antithrombotic efficacy in vivo using the arteriovenous shunt model and the ferric chloride-induced arterial thrombosis model in rats. The results show that the bromophenol derivative is a potential inhibitor of thrombin (IC₅₀=1.03 nmol/L). In antithrombotic experiments in vivo, the bromophenol derivative also shows good effect comparing with the control group. These data indicate that the bromophenol derivative is a potential drug for prophylaxis and the treatment of thrombotic diseases.     

援建江油勘查工作有感

宛城古来名镇扬,光武起兵定朝纲。汉末孔明躬耕处,演兵习武卧龙岗。火烧新野博望坡,惊魂走马曹丞相。     

华北构造区主要地震带分段与强震活动div

在华北构造区划分出银川——河套地震带、汾渭地震带、河北平原地震带、东秦岭——大别地震带、郯庐地震带和长江下游——黄海地震带等6个地震带,并依据地震带构造特征和地震活动的差异性,将其中汾渭地震带划分为延庆——代县段、原平——襄汾段和侯马——渭河段;河北平原地震带划分为三河——涞水段、唐山——邢台段和安阳——成武段;郯庐地震带划分为开原——辽东湾段、渤海段、潍坊——嘉山段和嘉山——广济段;银川——河套地震带初步划分为银川段和河套段．同时,对河北平原地震带南界及其与东秦岭——大别地震带的关系,地震带不同区段存在的主震型和多震型特点,以及可能发生强震的危险区段进行了初步探讨．