Effect of Groundwater Fluctuations on Pore Pressures and Earth Pressures on Coastal Excavation Retaining Walls

Pore water and earth pressures acting on retaining structures are investigated using an efficient coastal double-layered excavation model to determine offshore excavation responses to groundwater fluctuations outside foundation pits. Total pore water pressure includes excess pore water pressure (due to groundwater fluctuations) and steady pore water pressure (due to steady seepage) determined using one-dimensional consolidation theory of double-layered soil and one-dimensional steady-state flow theory, respectively. Rankine's active and passive earth pressures are obtained from pore water pressure. This method is applicable to arbitrary groundwater fluctuation conditions. How physical parameters affect pore water pressure is numerically investigated using examples, demonstrating the method's practicality for calculating pore water and earth pressures.     

黄河口潮滩泥沙絮凝研究

本文基于现场观测的絮团粒径、悬沙浓度及水动力数据,研究了黄河口南部潮滩泥沙絮凝特征。研究发现,黄河口潮滩絮团粒径在25.42～264.44 μm之间,平均为95.20 μm。水体紊动对黄河口潮滩絮凝的影响存在差异,紊动对絮凝促进作用的上限约为G_l=3.76 s⁻¹。紊动强度低于G_l时,紊动促进泥沙絮凝,絮团粒径随紊动加强而增大;反之水体紊动对絮凝主要起抑制作用,絮团粒径随紊动强度增大而减小。悬沙浓度对黄河口潮滩泥沙絮凝起抑制作用,同等紊动条件下高悬沙浓度对应的絮团粒径更小。黄河口潮滩絮团有效密度与粒径呈现负相关关系,沉速主要受粒径影响。本研究补充了对弱潮河口潮滩泥沙絮凝特性的认识。     

Self-Weight Penetration Characteristics of the Suction Foundation with Different Diameters in Sand

During the self-weight penetration process of the suction foundation on the dense sand seabed, due to the shallow penetration depth, the excess seepage seawater from the outside to the inside of the foundation may cause the negative pressure penetration process failure. Increasing the self-weight penetration depth has become an important problem for the safe construction of the suction foundation. The new suction anchor foundation has been proposed, and the self-weight penetration characteristics of the traditional suction foundation and the new suction anchor foundation are studied and compared through laboratory experiments and analysis. For the above two foundation types, by considering five foundation diameters and two bottom shapes, 20 models are tested with the same penetration energy. The effects of different foundation diameters on the penetration depth, the soil plug characteristics, and the surrounding sand layer are studied. The results show that the penetration depth of the new suction foundation is smaller than that of the traditional suction foundation. With the same penetration energy, the penetration depth of the suction foundation becomes shallower as the diameter increases. The smaller the diameter of the suction foundation, the more likely it is to be fully plugged, and the smaller the height of the soil plug will be. In the stage of self-weight penetration, the impact cavity appears around the foundation, which may affect the stability of the suction foundation.

     

基于网络药理学和分子对接技术探究柯里拉京治疗卵巢癌的关键靶点及分子机制

目的：采用网络药理学和分子对接技术相结合的方法探究柯里拉京（Cor）治疗卵巢癌的关键作用靶点和分子机制。方法：利用PharmMapper、TargetNet及Swiss Target Prediction在线工具预测Cor的作用靶点,通过OMIM、TTD、CTD、DisGenet、PharmGKB及MalaCards数据库获取卵巢癌相关的疾病靶点,并将药物靶点与疾病靶点取交集得到Cor治疗卵巢癌的预测靶点。借助STRING数据库、Cytoscape 软件构建蛋白质-蛋白质相互作用（PPI）网络,并采用CentiScape插件筛选出PPI网络中的核心靶点。运用GEPIA和Kaplan-Meier Plotter在线平台分别对这些核心靶点进行基因表达差异分析和生存分析,以明确Cor治疗卵巢癌的关键靶点。利用DAVID数据库进行基因本体（GO）功能及京都基因与基因组百科全书（KEGG）通路富集分析。运用Autodock Vina软件进行正向分子对接,预测关键靶点和Cor之间的结合活性。结果：Cor治疗卵巢癌的预测作用靶点共24个,其中RAC-α丝氨酸/苏氨酸蛋白激酶(AKT1)、表皮生长因子受体(EGFR)、雌激素受体1(ESR1)、原癌基因酪氨酸蛋白激酶(SRC)是Cor治疗卵巢癌的关键靶点,主要涉及血管内皮生长因子(VEGF)信号通路、缺氧诱导因子-1(HIF-1)信号通路及叉头样转录因子(FoxO)信号通路,可能通过调控细胞凋亡、细胞增殖、血管内皮细胞迁移等生物过程而发挥治疗卵巢癌的作用。分子对接结果显示,Cor与预测靶点之间具有较好的亲和力,表明通过网络药理学预测作用靶点的方法具有良好的可靠性。结论：Cor是通过多靶点、多通路的协同作用来干预多个生物过程,从而发挥其抗卵巢癌疗效,为进一步研究其治疗卵巢癌的分子机制提供了新的线索。     

石榴石橄榄岩的熔融实验及其地质意义

在20×10~9Pa和25×10~9Pa条件下,对石榴石橄榄岩进行的14次高温高压熔融实验研究表明,在1600℃时石榴石橄榄岩开始熔融(初熔),熔体中的SiO_2>70％,Na_2O+K_2O>8％,类似于A型花岗岩成分。本实验为地幔花岗岩的成因提供了证据。     

中国海相探矿权区块定量评价方法

在研究了我国海相油气探矿权区块基本油气地质条件、勘探程度、技术经济条件等要素和特点的基础上,给出了48个评价参数和归一化取值参照表,建立了探矿权区块评价工作流程、评分参数及计算公式。提出对我国海相勘探层探矿权区块评价应该注意:与国外海相碳酸盐岩评价的差别;与国内陆相碎屑岩评价的差别;成藏组合的划分;评价内容的有效性、不确定性和评价参数的可信度;成败经验的总结和勘探程度的研究。     

澜沧—耿马地震震源动力学参数研究

本文使用沧澜—耿马地震主震后在震区建立的数字地震仪记录,用波谱法测算澜沧—耿马余震的震源动力学参数。就这些参数的统计特征,对该双主震型两主震区的地下介质不同状态予以讨论。     

The roles of different mechanisms related to the tide-induced fronts in the Yellow Sea in summer

In summer, the Yellow Sea Cold Water Mass （YSCWM） is a stable water mass of low temperature lying at the bottom of the central Yellow Sea （YS）. It is fringed by some typical tidal fronts, which separate deep, stratified water on the offshore side from the well-mixed, shallow water on the inshore side. Three striking fronts--Subei Bank Front （SBF）, Shandong Peninsula Front （SPF）, and Mokpo Front （MKF; a front off the southwestern tip of the Korean Peninsula）--have been iden- tified by various studies from both satellite observations and model results. Tide plays an important role in the formation and maintenance of these fronts. However, it is still a matter of debate as to the roles these two kinds of mechanisms of upwelling and tidal mixing play, and how importance they are in the maintenance processes of the above three fronts. Basing a nested high-resolution model HYCOM （the Hybrid Coordinate Ocean Model）, this study focuses on the different mechanisms of tidal effects on the thermal fronts in the YS in summertime. Through comparative experiments with and without tidal forcing, the results indicate that the MKF is mainly driven by tide-induced upwelling. For the SPF, tidal mixing is the dominant factor, when lower cold water is stirred upwards along the sloping topography of the western YS. Meanwhile, the combined effect of upwelling and tidal mixing is the main cause of the formation of the SBF. Diagnostic analysis of thermal balance shows that horizontal nonlinear advection induced by strong tidal currents also contributes to the thermal balance of frontal areas.     

油气和含油气包裹体及其在油气地质地球化学研究中的意义

本文在综合前人研究的基础上，结合笔者的工作经验，提出了一个实用的油气和含油气包裹体分类方案，详细论述了各类油气和含油气包裹体的相态、组成和均一温度特征。在同一油气藏，均一温度越高，油相包裹体中的气态烃和挥发份的含量也越高。依据油相包裹体的均一温度的变化及其与同生水溶液包裹体的均一温度的关系可以研究油气藏在充填过程中油气组成，特别是气态烃和挥发份含量的演变。进而可以研究油气藏的油源--生油岩的类型和热演化程度。本文评述了依据油相包裹体和同生水溶液包裹体ＰＶＴ相图推断其捕获温度和压力范围的有效性和局限性。最后讨论了各类油气和含油气包裹体的成因机制及其在油气地质和地球化学研究中的意义。     

SAR重构分辨率对海冰侧向融化量预测影响研究

利用RADASAT-2的海冰SAR图像,分别采用Prewitt、Sobel和Canny边缘检测算子计算图像范围内的海冰周长,分析不同图像分辨率、不同边缘检测算子分别对周长计算结果产生的影响。结合冰层侧向融化速率参数化方案进行了海冰侧向融化温度敏感性模拟实验,分析了图像重构分辨率对海冰侧向融化结果的影响。结果表明：海冰破碎程度不同时,对应不同的最佳边缘检测算子和最佳分辨率;仅考虑侧向融化时,随着温度升高,3种算子模拟的海冰面积融化趋势基本一致,均呈指数型增加,Prewitt算子模拟效果最好,对应的最佳重构分辨率为30 m×30 m、65 m×65 m和155 m×155 m。