噻唑烷酸对肝组织GSH含量的影响及其作用机制的研究

建立丁胱亚磺酰亚胺(L-Buthionine Sulfoximine,BSO)排空小鼠肝组织谷胱甘肽(Glutathione,GSH)模型,研究噻唑烷酸(N-acetyl-glucosamine-thiazolidine-4(R)-carboxylic acid,GlcNAcCys)提高肝组织GSH含量,保护肝脏免受外源性毒物、药物损伤的可能机制。正常对照组小鼠腹腔注射生理盐水,BSO组及GlcNAcCys不同剂量组小鼠注射BSO(6mmol/kg体质量,i.p.)。2 h后,正常对照组和BSO组注射生理盐水,GlcNAcCys低、中、高剂量组分别注射不同剂量的GlcNAcCys(200、4009、00 mg/kg体质量)。6 h后,用Ellman’s法测定肝匀浆总巯基(Total Sulfhydryl,T-SH)含量;荧光分光光度法测定GSH含量;用试剂盒检测肝匀浆中谷胱甘肽还原酶(Glutathione Reductase,GR)和谷胱甘肽-S转移酶(Glutathione S-transferase,GST)活性;RT-PCR法检测谷氨酰半胱氨酸连接酶催化亚基(Glutamyl-L-cysteine Ligase,GCL)基因表达。GlcNAcCys能够提高肝匀浆中T-SH和GSH含量,增强抗氧化酶GR、GST活性,RT-PCR结果显示,GlcNAcCys能够诱导GCL mRNA的表达。GlcNAcCys能够提高肝组织T-SH、GSH的含量,增强GST、GR酶活力,增强肝脏的解毒功能,保护肝脏免受毒性中间代谢物的损伤。GlcNAcCys提高肝组织T-SH、GSH含量的机制与其诱导GCLmRNA的表达有关。     

南海西沙西南海域表层沉积物特征

西沙西南海域表层沉积物样品矿物成分，地球化学，微体古生物分析测试结果表明：沉积物可分为７种类型，沉积环境主要是陆坡，部分为深海平原，海洋生物，海洋化学以及火山物质的沉积起到了积极的作用，陆源物质的影响较小，它们主要来源于北部大陆和南部岛礁等物源区。     

利用GPS拖体在万山区域测量平均海面技术研究

Wanshan area has been chosen to be the specified field to calibrate and validate(Cal/Val) the HY-2 altimeter and its follow-on satellites. In March 2018, an experiment has been conducted to determine the sea surface height(SSH) under the HY-2 A ground track(Pass No. 203). A GPS towing-body(GPS-TB) was designed to measure the SSH covering an area of about 6 km×28 km wide centered on the HY-2 A altimeter satellite ground track. Three GPS reference stations, one tide gauge and a GPS buoy were placed in the research area, in order to process and resolve the kinematic solution and check the precision of the GPS-TB respectively. All the GPS data were calculated by the GAMIT/GLOBK software and TRACK module. The sea surface was determined by the GPS-TB solution and the tide gauge placed on Zhiwan Island. Then the sea surface of this area was interpolated by Arc GIS10.2 with ordinary Kriging method. The results showed that the precision of the GPS-TB is about 1.10 cm compared with the tide gauge placed nearby, which has an equivalent precision with the GPS buoy. The interpolated sea surface has a bias of –1.5–4.0 cm with standard deviation of 0.2–2.4 cm compared with the checking line. The gradient of the measured sea surface is about 1.62 cm/km along the HY-2 orbit which shows a good agreement compared with the CLS11 mean sea surface(MSS). In the Cal/Val of satellites, the sea surface between the tide gauge/GPS buoy and the footprint of altimeter can be improved by this work.     

Holocene cheniers in the Yangtze Delta, China

Nineteen cheniers formed in the middle and late Holocene have been distinguished and studied.

In fair weather the wave action along the Yangtze Delta is weak, with a wave height of 0.5–1.0 m and average wave energy of 0.127 erg/s. However, in late summer and early autumn the coastal area is usually swept by typhoons, which sometimes are extremely violent. The development of cheniers is mainly controlled by these strong typhoons. As a result, a number of the sedimentary characteristics of the cheniers are related to the typhoon-generated high-energy environment.

Moreover, the study shows that the top elevation of a fully developed chenier indicates the spring high water level during a violent typhoon (11–12 on the Beaufort scale).     

三种海产帘蛤目贝类的核型研究

以大竹蛏、紫石房蛤和中国蛤蜊的鳃组织为材料,经注射植物血球凝集素和秋水仙素处理,低渗作用后,采用滴片法和压片法制片,对3种贝的核型进行了研究.结果表明,3种贝类的二倍体染色体数均为38条,大竹蛏的核型为26m+6sm+2st+4t,NF=0;紫石房蛤的核型为32m+2sm+4st/t,NF=2;中国蛤蜊的核型为20m+16sm+2st/t,NF=4.在3种贝类的染色体中均未发现随体及性染色体.     

太平洋三海区热液烟囱物的氧同位素特征及形成温度

使用氧同位素方法 ,测试了西太平洋马里亚纳岛弧、马里亚纳海槽、冲绳海槽和东太平洋加拉帕戈斯裂谷的海底热液烟囱和硫化物全岩样品。结果表明 :马里亚纳岛弧上的埃斯梅拉尔达破火山口的热液硫化物的形成温度最高 (达 2 75℃ ) ,而成为高温产物的代表 ;冲绳海槽和加拉帕戈斯裂谷烟囱 ,表现为中高温类型 ,其氧同位素温度在 1 5 0℃左右 ;马里亚纳海槽以蛋白石为主要矿物的烟囱物 ,则显示出典型的低温热液类型 ,少量黄铁矿砂试样则表现出中温类型特征。但上述区域大都不同程度地存在有闪锌矿、黄铁矿、黄铜矿等中高温热液矿物 ,说明研究区除马里亚纳海槽明显有中低温热液活动类型外 ,其它区域皆具备中高温热液活动特征     

用于极地的中尺度大气模式Polar MM5的改进和检验

介绍了一个用于极地研究的中尺度大气模式———Polar MM5,阐述了该模式区别于标准的中尺度大气模式MM5的动力学和物理特征。利用Polar MM5获得了10 d的模拟结果表明,Polar MM5能较好地模拟高纬度地区近地面气象变量特征,尤其是对近地面温度和水汽混合比可得到高精度模拟结果,证实了在高纬度地区对标准MM5所进行的物理参数化方案的改进是切实有效的。     

地基-非线性结构相互作用体系的主共振与分叉

本文考虑上部结构的恢复力为双线型模型,地基上简化为集中参数模型,运用平均法研究相互作用体系的主共振,得到主共振的定数解并讨论其稳定性。文中导出相互作用体系的分叉方程,并根据厅异性理论给出开折参数平面下的分叉图和转迁集,讨论不同物理参数域内系统的振动行为并通过算例得到一些定性的结论。     

Differential gene expression in the body wall of the sea cucumber(Apostichopus japonicus) under strong lighting and dark conditions

Sea cucumber, Apostichopus japonicus is very sensitive to light changes. It is important to study the influence of light on the molecular response of A. japonicus. In this study, RNA-seq provided a general overview of the gene expression profiles of the body walls of A. japonicus exposed to strong light("light"), normal light("control") and fully dark("dark") environment. In the comparisons of "control" vs. "dark", "control" vs. "light" and "dark" vs."light", 1 161, 113 and 1 705 differentially expressed genes(DEGs) were identified following the criteria of|log_2 ratio|≥1 and FDR≤0.001, respectively. Gene ontology analysis showed that "cellular process" and "binding"enriched the most DEGs in the category of "biological process" and "molecular function", while "cell" and "cell part" enriched the most DEGs in the category of "cellular component". And the DEGs were mapped to 214, 41 and229 pathways in the Kyoto Encyclopedia of Genes and Genomes database, and 51, 2 and 57 pathways were significantly enriched, respectively. Light-specific DEGs identified in this study will be important targets for further investigation to establish the biochemical mechanisms involved in the adaption of this sea cucumber to changes in the level of environmental light.     

Processes of the deposition and vicissitude of Mu Us Desert, China since 150 ka B.P.

“Milanggouwan stratigraphical section” named lately takes down 27 cycles of alternately evolutionary histories of desert depositions in the Mu Us area with the fluviolacustrine facies and palaeosols since 150 ka B. P. Studies show that the sedimentary form was induced by the growth and decline and confrontation each other between the winter monsoon and the summer monsoon of East Asia in the past 150 ka. Project supported by the National Natural Science Foundation of China (Grant No. 49473192).