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841.
目的:运用网络药理学方法研究桔梗治疗肺动脉高压(PH)的作用机制。方法:通过中药系统药理学数据库与分析平台(TCMSP)筛选桔梗有效化合物及其作用靶点,使用Gene Cards数据库筛选疾病候选靶点,利用Cytoscape-v 3.7.2软件构建化合物-靶点-疾病网络,运用String数据平台绘制蛋白相互作用网络,运用R软件分析靶基因的GO功能,使用DAVID数据库分析KEGG通路。结果:桔梗治疗PH的有效化合物包含木犀草素、金合欢素、菠菜甾醇及顺式-二氢槲皮素,相关潜在靶点涉及PTGS1、PTGS2、HSP90AA1等。GO功能富集分析显示预测靶点主要与氧化应激反应、细胞生长增殖等生物过程及细胞因子活性、细胞因子与受体结合情况、氧化还原酶活性等分子功能相关。KEGG富集分析显示潜在基因主要集中在白细胞介素-17、磷脂酰肌醇3-激酶-蛋白激酶B、缺氧诱导因子-1等信号通路。结论:桔梗可能通过抗炎、抗氧化应激、促血管舒张及抑制平滑肌细胞增殖等机制发挥治疗PH的作用。 相似文献
842.
目的:观察益心通络利水方对急性ST段抬高型心肌梗死(STEMI)PCI术后心衰患者心肌重构的影响。方法:选取STEMI PCI术后心衰患者140 例,按照随机数字表法将其分为2组,每组各70 例。对照组采用西医常规治疗方案,治疗组在对照组基础上加用益心通络利水方治疗,2组均连续治疗4周。比较治疗后2组患者中医证候疗效,测量并比较治疗前后2组患者左房内径、左室内径、左室射血分数(LVEF),并利用三维斑点追踪成像(3D-STI)技术观察左室整体纵向应变(GLS)、径向应变(GRS)及圆周应变(GCS)。结果:总有效率治疗组为92.8%(65/70),对照组为74.3%(52/70),组间比较,差异有统计学意义(P<0.05);治疗后治疗组左房内径、左室内径、LVEF较治疗前均有改善,且较对照组改善明显,差异均有统计学意义(P<0.05);2组GLS、GRS、GCS值治疗前后组内比较及治疗后组间比较,差异均有统计学意义(P<0.05或P<0.01)。结论:益心通络利水方能够改善STEMI PCI术后患者临床症状及心肌重构,提高心功能,3D-STI能够更早期、敏感、准确地评价介入术后心衰患者的心脏收缩功能。 相似文献
843.
降水是全球能量/水循环中的重要过程。本文着重分析 FY-3 气象卫星降水探测能力,展望风云卫星后续规划中降水探测技术的发展前景。分析表明,以 FY-3 降水星为主星,与其他 FY-3 极轨卫星组成的 FY-3 气象卫星降水探测体系,在设计层面上,从载荷类型、数量、通道设置等方面均优于由美国发起并已在轨运行的全球降水测量(Global Precipitation Measurement,GPM)计划核心星的设计性能。FY-3 降水星设计装载 Ka / Ku 双频降水测量雷达,卫星轨道设计覆盖南北纬 50°范围内的中低纬地区,对影响我国区域的台风暴雨等强对流天气系统结构具有三维探测能力。FY-3 气象卫星星座的降水探测能力为气象防灾减灾提供了基础支撑。 相似文献
844.
845.
Research on ecosystem service consumption not only helps to reveal the utilization intensity and management level of the ecosystem in Guilin, but it also provides a scientific basis for ecosystem investment, trade, subsidies and taxation by the Guilin government departments. Based on household survey data of urban and rural ecological consumption, the physical quantity accounting method is adopted for multivariate statistical analyses, such as analysis of variance and multiple comparison. This analysis reveals the differences and changes in the consumption level, consumption structure and consumption pattern of the main ecological products in Guilin among the various counties. The results fit into four main themes. (1) The annual per capita consumption of the main ecological products in Guilin varies either extremely significantly or significantly among the counties, but the consumption level of ecological products varies according to the type of products. There are significant or extremely significant differences in the annual per capita consumption of cereals, melons and fruits, pork, poultry, beef and mutton, fresh eggs and milk between urban and rural residents. (2) There are extremely significant differences in the annual per capita consumption of fruits, pork, poultry, beef and mutton, fish, fresh milk and vegetable oil among urban residents in different counties. There are also extremely significant differences in the annual per capita consumption of cereals, pork, poultry and alcohol among rural residents in different counties, and significant differences in the annual per capita consumption of fresh eggs and milk. The consumption level of ecological products by urban and rural resident varies with the type of products. (3) The ecological consumption patterns of all counties in Guilin mainly follow the “cereal + vegetable + fruit + meat” pattern for urban residents and the “cereal + vegetable + meat” pattern for rural residents (except for the rural residents in Pingle, which show the “cereal + vegetable” pattern). The consumption structure of urban residents is better than that of rural residents. (4) There is a large gap between the ecological consumption of urban and rural residents in Guilin and China's recommended standards, except for cereals and meat. The main problems are excessive meat intake, and insufficient intake of dark vegetables, fruits, eggs, milk and fish. Therefore, we should make full use of forestland, grassland, water and other resources in the area, and vigorously develop fishery, fruit and vegetable production and herbivorous animal husbandry to meet people's ecological needs for dark fruits and vegetables, eggs, milk and fish in Guilin City. 相似文献
846.
Wang Caixia Wang Min Chen Binbin Qin Wenli Lin Lidong Dai Chuanjun Yu Hengguo Li Renhui Zhao Min Ma Zengling 《中国海洋湖沼学报》2021,39(6):2237-2251
Journal of Oceanology and Limnology - Harmful algal bloom (HAB) is an ecological disaster to local mariculture. At present, its impact on macrophytes has not been well studied. In this study, we... 相似文献
847.
测定14周龄贵妃鸡的体尺与屠宰性能相关指标,通过简单相关和典型相关分析,研究贵妃鸡体尺与屠宰性能的相关关系。结果表明:贵妃鸡公母鸡14周龄体质量分别为1 120.67 g和845.33 g,公鸡的体尺和屠宰性能(全净膛质量除外)均高于母鸡(P0.01);体尺与屠宰性能指标间存在不同程度的相关性,其中有2对典型相关系数达到了显著水平(P0.05),典型相关系数分别为0.985和0.824,体尺和屠宰性能的相关性主要由胫围、龙骨长、屠体质量、体质量和半净膛质量间引起;贵妃鸡可通过体尺选择提高屠宰性能。 相似文献
848.
849.
850.
Land cover change affects surface radiation budget and energy balance by chang- ing surface albedo and further impacts the regional and global climate. In this article, high spatial and temporal resolution satellite products were used to analyze the driving mechanism for surface albedo change caused by land cover change during 1990-2010. In addition, the annual-scale radiative forcing caused by surface albedo changes in China's 50 ecological regions were calculated to reveal the biophysical mechanisms of land cover change affecting climate change at regional scale. Our results showed that the national land cover changes were mainly caused by land reclamation, grassland desertification and urbanization in past 20 years, which were almost induced by anthropogenic activities. Grassland and forest area decreased by 0.60% and 0.11%, respectively. The area of urban and farmland increased by 0.60% and 0.19%, respectively. The mean radiative forcing caused by land cover changes during 1990-2010 was 0.062 W/m2 in China, indicating a warming climate effect. However, spatial heterogeneity of radiative forcing was huge among different ecological regions. Farmland conversing to urban construction land, the main type of land cover change for the urban and suburban agricultural ecological region in Beijing-Tianjin-Tangshan region, caused an albedo reduction by 0.00456 and a maximum positive radiative forcing of 0.863 WIm2, which was presented as warming climate effects. Grassland and forest conversing to farmland, the main type of land cover change for the temperate humid agricultural and wetland ecological region in Sanjiang Plain, caused an albedo increase by 0.00152 and a maximum negative radiative forcing of 0.184 W/m2, implying cooling climate effects. 相似文献