基于数据挖掘分析中药复方治疗肺癌伴恶性胸腔积液的用药规律

目的：运用中医传承计算平台（V3.0）分析中医药治疗肺癌伴恶性胸腔积液的用药规律。方法：计算机检索2000年1月1日至2022年2月28日中国知网（CNKI）、万方数据（WANFANG DATA）、维普中文科技期刊数据库（VIP）中关于中药复方治疗肺癌伴恶性胸腔积液的文献,分析中药的性味归经、功效、频次、药物组合、关联规则及聚类等。结果：共纳入文献98篇,处方103首,中药197味。频次≥20次的中药有18味,排前10位的依次为葶苈子、茯苓、白术、黄芪、大枣、甘草、泽泻、桂枝、半夏、薏苡仁。四气以寒、温、平为主;五味以甘、苦、辛为主;归经以肺、脾、胃经为主。排前3位的功效依次为补虚、利水渗湿、化痰止咳平喘。用药频次≥20次的中药组合有37组,排前4位的依次为茯苓-葶苈子、白术-茯苓、茯苓-黄芪、大枣-葶苈子。支持度≥25%的核心药物为黄芪、白术、茯苓、甘草、葶苈子、大枣、桂枝、泽泻。中药聚类分析提取到4个核心组合。结论：肺癌伴恶性胸腔积液多属晚期,以气血阴阳俱虚为本,饮停胸胁为标,病机多虚实夹杂。中医药治疗此病多以甘温益气补虚治本,苦寒泻肺利水治标,同时兼以温阳化气。     

Complex adaptive blended learning for higher GIS education: A theory-driven pedagogy moving forward after the pandemic

None of the prior studies implementing blended learning (BL) for GIS education has explored pedagogical theories to support BL design, and none coupled blended GIS learning practice with theories. Based on the theoretical framework of complex adaptive blended learning system (CABLS), this article presents a holistic and systematic view of BL for higher GIS education (termed as CABLS-GIS), where its key components are tightly integrated as an integral whole. The framework was implemented for an introductory-level GIS course to empirically evaluate the effectiveness of a BL design from students' perspectives. Most students involved in the implementation agreed that the BL enhanced their learning outcomes. They were mostly positive about the BL and motivated to use the BL materials. Incorporating more BL materials, especially practical ones, and active learning activities were suggested by them. A few negative comments about the BL suggested a thorough consideration of individual learners' characteristics.     

黄山风景区旅游废弃物生态足迹历时性分析

历时性旅游废弃物演化规律及生态影响研究是制定旅游地可持续发展战略的基础性工作。以生态足迹理论为基础,利用1979—2018年相关统计资料与团队实地调研数据,对黄山风景区旅游废弃物生态足迹的长时间序列动态变化进行特征研究。结果表明（：1）黄山风景区旅游废弃物生态足迹演变具有明显的阶段性特征,共分为1979—1987年持续上升、1988—1996年小范围浮动式下降、1997—2005年剧烈振荡以及2006—2018年趋于稳定四个阶段。（2）黄山风景区旅游废弃物生态足迹的来源及构成占比随着当地垃圾处理方式及污染防治措施的变化而变化。其中,固体垃圾的足迹占比最多且达到52.18%～97.99%,并从显性与隐性两方面对当地生态环境产生影响。（3）随着黄山风景区旅游经济增长,区域资源利用效益持续升高,环境质量稳定改善,始终处于可持续发展状态。（4）黄山风景区的实践表明成熟的环境管理体制和不断改进的卫生治理措施可将旅游废弃物造成的生态影响控制在一定范围之内,从而为其他山岳型景区可持续发展提供有益参考。     

Transcriptome profile of Dunaliella salina in Yuncheng Salt Lake reveals salt-stress-related genes under different salinity stresses

Journal of Oceanology and Limnology - Salt stress is an abiotic stress to plants in especially saline lakes. Dunaliella, a halophilic microalga distributed throughout salt lakes and seas, can...     

MamZ protein plays an essential role in magnetosome maturation process of Magnetospirillum gryphiswaldense MSR-1

Journal of Oceanology and Limnology - Based on analysis of gene structure of mamXY operon in Magnetospirillum gryphiswaldense strain MSR-1, we constructed a mamZ deletion mutant strain (ΔmamZ)...     

Numerieal prediction of storm surge in the Qingdao area under the impact of climate change

A typhoon-induced storm surge simulation system was developed for the Qingdao area, including a typhoon diagnostic model for the generation of wind and pressure fields and a 2D Advanced Circulation (ADCIRC) model for simulating the associated storm surge with a 200 m resolution along the Qingdao coastline. The system was validated by an extreme surge event Typhoon Mamie (8509) and the parameters of Typhoon Mamie were used to investigate the sensitivity of typhoon paths to Qingdao storm surges with four selected paths: the paths of Typhoons Mamie (8509), Opal, 3921 and 2413, the selection being made according to their relative position to Qingdao. Experiments based on the Typhoon Mamie (8509) storm surge were also conducted to study the possible influences of future climate changes, including the sea level rise and sea surface temperature (SST) rise, on storm surges along the Qingdao coast. Storm surge conditions under both present day and future (the end of the 21st century) climate scenarios associated with the four selected paths were simulated. The results show that with the same intensity, when typhoons follow the paths of 3921 and 2413, they would lead to the most serious disasters in different areas of Qingdao. Sea level and SST affect storm surges in different ways: sea level rise affects storm surge mainly through its influence on the tide amplitude, while the increased SST has direct impact on the intensity of the surges. The possible maximum risk of storm surges in 2100 in the Qingdao area caused by typhoons like Mamie (8509) was also estimated in this study.     

云南剑川地区象鼻洞遗址孢粉组合和古环境

为了解云南剑川旧石器时代中晚期植被和气候变化特点以及当地环境与人类活动的关系,选取象鼻洞遗址各地层的13个土样进行孢粉分析。结果表明:该遗址堆积时期孢粉植物群以亚热带和温带成分为主,类型相对丰富,呈温暖期气候特征,但气候存在小的波动,呈现出早期温暖湿润、中期短暂干旱、晚期又逐渐暖湿的特点;木本植物花粉在孢粉总量中占绝对优势,说明当时人类活动对自然环境的影响不明显;可作为食物来源的植物很少,因此,当时居住在象鼻洞的人类主要食物应来源于捕捞或狩猎;对照邻近地区已有的研究成果,推测该遗址气候变化与季风活动有关。     

青海省化隆县柏木峡地区找矿前景探析

青海省化隆县柏木峡地区构造及岩浆岩发育,根据在该区实施的1∶2.5万水系沉积物测量结果,各元素异常套合好,同时在异常区见有金矿化点及铅矿化点,认为该区成矿条件优越,找矿前景较好。