Does geographic location impact the survival differential between screen- and interval-detected breast cancers?

Although mammography screening programs aim to diagnose breast cancer at an early stage, not all tumours are detected during the regular screening examination. This study examines the influence of various characteristics, including geographical residence, on the survival between screen- and interval-detected breast cancers among participants of a public population-based breast screening program in Queensland, Australia. The investigation was performed using the linked population-based datasets from BreastScreen Queensland and the Queensland Cancer Registry for the period of 1997–2008 for women aged 40–89 years at diagnosis. A Bayesian spatial relative survival modelling approach that accommodates rare outcomes in small geographic regions was adopted, with the use of Markov chain Monte Carlo computation, to evaluate the relative excess risk of breast cancer. In the multivariate Bayesian spatial model, higher relative excess risk of mortality was observed in interval-detected cancer (RER = 1.59, 95 % credible interval = [1.33, 1.89]) compared to screen-detected cancer. Higher cancer survival among the study cohort was also observed among younger women (40–59 years), those of non-Indigenous ethnicity, with localised (stage I) tumour stage as well as those not in the work force. There was no independent association with marital status. Moreover, there was no substantive evidence of either measured geographical or latent random spatial inequalities in survival among screening participants across Queensland, meaning the higher survival for screen-detected breast cancer patients compared to interval-detected women was consistent across the state. These results provide suggestive evidence supporting the effectiveness of the BreastScreen Queensland screening program in reaching socio-economically disadvantaged women as well as those living in rural and remote areas of the state, but also highlights the need for any interval cancer awareness programs to be geographically widespread.     

Annual to decadal morphodynamics of the foredune system at Greenwich Dunes,Prince Edward Island,Canada

The purpose of this study was to quantify relationships between season, sediment availability, sediment transport pathways, and beach/foredune morphology at Greenwich Dunes, PEI. This was done for periods ranging from a few days to multiple decades using erosion pins, bedframe measurements, annual surveys, and digital photogrammetry using historical aerial photographs. The relative significance of seasonal/annual processes versus response of the foredune system to broader geomorphic controls (e.g. relative sea level rise, storms, etc.) was also assessed. The data show that there are clear seasonal differences in the patterns of sand supply from the beach to the foredune at Greenwich and that there are differences in sediment supply to the foredune between the east and west reaches of the study area, resulting in ongoing differences in foredune morphology. They also demonstrate that models that incorporate wind climate alone, or even models that include other factors like beach moisture, would not be able to predict the amount of sediment movement from the beach to the foredune in this environment unless there were some way to parameterize system morphology, especially the presence or absence of a dune ramp. Finally, the data suggest that the foredune can migrate landward while maintaining its form via transfers of sediment from the stoss slope, over the crest, and onto the lee slope. Although the rate of foredune development or recovery after disturbance changes over time due to morphological feedback, the overall decadal evolution of the foredune system at Greenwich is consistent with, and supports, the Davidson‐Arnott (2005) conceptual model of dune transgression under rising sea level. Copyright © 2012 John Wiley & Sons, Ltd.     

A large landslide event in a post‐glacial landscape: rethinking glacial legacy

Threlkeld Knotts (c. 500 m above sea level) in the English Lake District has hitherto been considered to be a glacially‐modified intrusion of microgranite. However, its surface features are incompatible with glacial modification; neither can these nor the subsurface structures revealed by ground‐penetrating radar (GPR) be explained by post‐glacial subaerial processes acting on a glacially‐modified microgranite intrusion. Here we re‐interpret Threlkeld Knotts as a very large post‐glacial landslide involving the microgranite, with an estimated volume of about 4 × 10⁷ m³. This interpretation is tested against published and recent information on the geology of the site, the glacial geomorphic history of the area and newly‐acquired GPR data. More than 60 large post‐Last Glacial Maximum (LGM) rock–slope failures have significantly modified the glaciated landscape of the Lake District; this is one of the largest. Recognition of this major landslide deposit in such a well‐studied environment highlights the need to continuously re‐examine landscapes in the light of increasing knowledge of geomorphic processes and with available technology in currently active or de‐glaciating environments. Copyright © 2012 John Wiley & Sons, Ltd.     

A strain-induced freshwater pump in the Liverpool Bay ROFI

Liverpool Bay is a region of freshwater influence which receives significant freshwater loading from a number of major English and Welsh rivers. Strong tidal current flow interacts with a persistent freshwater-induced horizontal density gradient to produce strain-induced periodic stratification (SIPS). Recent work (Palmer in Ocean Dyn 60:219–226, 2010; Verspecht et al. in Geophys Res Lett 37:L18602, 2010) has identified significant modification to tidal ellipses in Liverpool Bay during stratification due to an associated reduction in pycnocline eddy viscosity. Palmer (Ocean Dyn 60:219–226, 2010) identified that this modification results in asymmetry in flow in the upper and lower layers capable of permanently transporting freshwater away from the Welsh coastline via a SIPS pumping mechanism. Observational data from a new set of observations from the Irish Sea Observatory site B confirm these results; the measured residual flow is 4.0 cm s⁻¹ to the north in the surface mixed layer and 2.4 cm s⁻¹ to the south in the bottom mixed layer. A realistically forced 3D hydrodynamic ocean model POLCOMS succeeds in reproducing many of the characteristics of flow and vertical density structure at site B and is used to estimate the transport of water through a transect WT that runs parallel with the Welsh coast. Model results show that SIPS is the dominant steady state, occurring for 78.2% of the time whilst enduring stratification exists only 21.0% of the year and enduring mixed periods, <1%. SIPS produces a persistent offshore flow of freshened surface water throughout the year. The estimated net flux of water in the surface mixed layer is 327 km³ year ⁻¹, of which 281 km³ year⁻¹ is attributable to SIPS periods. Whilst the freshwater component of this flux is small, the net flux of freshwater through WT during SIPS is significant, the model estimates 1.69 km³ year⁻¹ of freshwater to be transported away from the coast attributable to SIPS periods equivalent to 23% of annual average river flow from the four catchment areas feeding Liverpool Bay. The results show SIPS pumping to be an important process in determining the fate of freshwater and associated loads entering Liverpool Bay.     

Recent ventifact development on the central Oregon coast,western USA

The unusual location of ventifacts, on a boulder‐built jetty at the mouth of the Siuslaw River, Oregon coast, western USA, allows ventifact age and wind abrasion rates to be estimated with some precision. The jetty was built mainly between 1892–1901 and extended throughout the twentieth century. Consideration of historical shoreline position and the history of jetty construction and repair suggests the ventifacts have formed since about 1930. Morphologically the ventifacts are aligned south‐to‐north reflecting winter winds and sediment transport from the adjacent beach. Wind‐parallel grooves and ridges with sharp, sinuous crests are developed on inclined boulder surfaces on top of the jetty and reflect suspended sand transport in wind vortices. Deeply pitted surfaces on steep boulder surfaces nearest the beach reflect impact by saltating sand grains. Based on present wind regimes (1992–2000) from three regional weather stations, southerly winds above the sand transport threshold occur for 21·9–29·6 per cent of the time. Based on estimated depth of loss from boulder surfaces, wind abrasion rates are calculated to be on the order of 0·24–1·63 mm a^?1. This is the first well‐constrained field estimate of ventifact age and ventifaction rate from a modern coastal environment. Copyright © 2003 John Wiley & Sons, Ltd.     

Temperature evolution between 50 K and 320 K of the thermal expansion tensor of gypsum derived from neutron powder diffraction data

The unit cell parameters, extracted from Rietveld analysis of neutron powder diffraction data collected between 4.2 K and 320 K, have been used to calculate the temperature evolution of the thermal expansion tensor for gypsum for 50 ≤ T ≤ 320 K. At 300 K the magnitudes of the principal axes are α ₁₁  = 1.2(6) × 10⁻⁶ K⁻¹, α ₂₂  = 36.82(1) × 10⁻⁶ K⁻¹ and α ₃₃  = 25.1(5) × 10⁻⁶ K⁻¹. The maximum axis, α ₂₂ , is parallel to b, and using Institution of Radio Engineers (IRE) convention for the tensor orthonormal basis, the axes α ₁₁ and α ₃₃ have directions equal to (−0.979, 0, 0.201) and (0.201, 0, 0.979) respectively. The orientation and temperature dependent behaviour of the thermal expansion tensor is related to the crystal structure in the I2/a setting. Received 12 February 1998 / Revised, accepted 19 October 1998     

Analytical expressions to determine the isothermal compressibility tensor and the isobaric thermal expansion tensor for monoclinic crystals: application to determine the direction of maximum compressibility in jadeite

Expressions are presented to allow the simple determination of the magnitudes and directions of the principal axes for the isothermal compressibility tensor and the isobaric thermal expansion tensor for monoclinic crystals. The method is applied to re-evaluate the apparently contradictory results that have recently been obtained for the direction of maximum compressibility in jadeite. The term ‘unit strain’ to describe these second rank tensors is discouraged and the use of the representation quadric for visualisation of second rank tensors is recommended.     

Shark interactions in pelagic longline fisheries

Substantial ecological, economic and social problems result from shark interactions in pelagic longline fisheries. Improved understanding of industry attitudes and practices towards shark interactions assists with managing these problems. Information on fisher knowledge and new strategies for shark avoidance may benefit sharks and fishers. A study of 12 pelagic longline fisheries from eight countries shows that incentives to avoid sharks vary along a continuum, based on whether sharks represent an economic disadvantage or advantage. Shark avoidance practices are limited, including avoiding certain areas, moving when shark interaction rates are high, using fish instead of squid for bait and deeper setting. Some conventionally employed fishing gear and methods used to target non-shark species contribute to shark avoidance. Shark repellents hold promise; more research and development is needed. Development of specifically designed equipment to discard sharks could improve shark post release survival prospects, reduce gear loss and improve crew safety. With expanding exploitation of sharks for fins and meat, improved data collection, monitoring and precautionary shark management measures are needed to ensure that shark fishing mortality levels are sustainable.