Use of suppressive subtractive hybridization and cDNA arrays to discover patterns of altered gene expression in the liver of dihydrotestosterone and 11-ketotestosterone exposed adult male largemouth bass (Micropterus salmoides)

In this study male largemouth bass (LMB) were exposed to the naturally occurring androgens, dihydrotestosterone (DHT) or 11-ketotestosterone (11-KT) in order to identify genes that are differentially regulated by these steroid hormones. Using subtractive hybridization on livers of fish treated with DHT against vehicle control, many novel LMB genes were cloned. These genes were added to our gene library and arrayed. Six genes were up-regulated and five were down-regulated by both androgens. But, each androgen also regulated specific genes. One gene that was identified as a potential androgen marker was spermidine-spermine-N(1)-acetyltransferase that was up-regulated by both androgens. Determining which genes are responsive to natural androgens will help to identify biochemical pathways that are impacted.     

PLL Tracking Performance in the Presence of Oscillator Phase Noise

The tracking performance of a Phase Lock Loop (PLL) is affected by the influence of several error sources. In addition to thermal noise and dynamic stress error, oscillator phase noise can cause significant phase jitter which degrades the tracking performance. Oscillator phase noise is usually caused by two different effects: Allan deviation phase noise is caused by frequency instabilities of the receiver's reference oscillator and the satellite's frequency standard. It can be termed as system-inherent phase noise and is relevant for both static and dynamic applications. “External” phase noise, however, is caused by vibration and is a major problem for dynamic applications. In the context of this paper, both types of phase noise will be modeled and the resulting integrals will be evaluated for PLLs up to the third order. Besides, phase jitter induced by thermal noise and signal dynamics will also be discussed, thus providing all necessary formulas for analyzing the performance of a phase lock loop in case of different forms of stress. Since the main focus is centered on the effects of oscillator phase noise, the overall PLL performance is graphically illustrated with and without consideration of oscillator phase noise. © 2002 Wiley Periodicals, Inc.     

Club convergence and spatial distribution dynamics of carbon intensity in China’s construction industry

Climate change caused by carbon emissions continuously threatens sustainable development. Due to China’s immense territory, there are remarkable regional differences in carbon emissions. The construction industry, which has strong internal industrial differences, further leads to carbon emission disparity in China. Policymakers should consider spatial effects and attempt to eliminate carbon emission inequality to promote the sustainable development of the construction industry and realize emission reduction targets. Based on the classic Markov chain and spatial Markov chain, this paper investigates the club convergence and spatial distribution dynamics of China’s carbon intensity in the construction industry from 2005 to 2014. The results show that the provincial carbon intensity in the construction industry is characterized by “convergence clubs” during the research period, and very low-level and very high-level convergence clubs have strong stability. Moreover, the carbon intensity class transitions of provinces tend to be consistent with that of their neighbors. Furthermore, the transition of carbon intensity types is highly influenced by their regional backgrounds. The provinces with high carbon emissions have a negative influence on their neighbors, whereas the provinces with low carbon emissions have a positive influence. These analyses provide a spatial interpretation to the “club convergence” of carbon intensity.     

The isotopic composition and elemental abundance of lutetium in meteorites and terrestrial samples and the 176Lu cosmochronometer

The isotopic composition of lutetium has been measured in a range of terrestrial and meteoritic materials using solid-source mass spectrometric techniques. The meteoritic and terrestrial isotopic abundances are identical within experimental errors. The absolute ¹⁷⁵Lu/¹⁷⁶Lu ratio as determined in this work is 37.36 ± 0.07 at the 95% confidence level. On the basis of this measurement the atomic weight of lutetium has been calculated to be 174.967 ± 0.002, which is in good agreement with the currently accepted figure of 174.97 ± 0.01.Using the stable isotope dilution technique the abundance of lutetium has been determined in 25 stone, 1 stony-iron and 8 iron meteorites, and in 12 standard rocks, with an accuracy of ±5% at the 95% confidence level. In general, there is good agreement between this work and other published data.The ¹⁷⁶Lu-¹⁷⁶Hf pair has been proposed as an s process nucleocosmochronometer, because of the long half-life of ¹⁷⁶Lu and the unique fact that both are s process isobars. The isotopic and elemental abundances of lutetium as measured in this work have been used with published nuclear data to estimate the mean age of s process nucleosynthesis for this isobaric pair, using the Schramm-Wasserburg formalism. The mean age cannot be accurately determined at the present time because of the lack of 30 keV neutron capture cross-section data for s only process nuclides and an accurate measurement of the branching ratio of ¹⁷⁵Lu + n. However, it is possible to place constraints on the nuclear parameters in this mass region using a reasonable s process chronology based on the decay of ¹⁷⁶Lu.     

A Late Pleistocene submarine slide on the Bear Island Trough Mouth Fan

A large submarine slide on the southern flank of the Bear Island Trough Mouth Fan, southwestern Barents Sea continental slope, has a run-out distance of about 400 km, a total volume of about 1100 km³, and is younger than 330 ka. Three seismic units, comprising mainly hemipelagic sediments has partly filled the slide scar. An increased sedimentation rate on the Bear Island Trough Mouth Fan from Late Pliocene time, probably in combination with abundant earthquakes, is the most likely cause of the slide. Based on these and previous studies, we suggest that large-scale slides were important sediment transport processes during Plio-Pleistocene.     

Experimental study of the mechanical properties of expansive soil with added nanomaterials

The main purpose of this paper is to describe ways to improve the microstructure of expansive soil by adding nanomaterials. Mechanical tests were done to explore the changes in shear strength and compression index of expansive soil that was modified by adding different amounts of two kinds of nanomaterials (nano-alumina and nano-silica). The test results show that adding 1.2% nano-alumina and about 2% nano-silica to expansive soil provides the optimal compression index. The test results show that adding 1.2% nano-alumina and about 1.5% nano-silica to expansive soil provides the optimal unconfined compression stress. Scanning electron microscopy of the microstructure of expansive soil modified by nanomaterials provided a deeper understanding of the effects of nanomaterials on improving expansive soil.     

A constitutive model for mechanical and chemo‐mechanical compaction in sedimentary basins and finite element analysis

Compaction and associated fluid flow are fundamental processes in sedimentary basin deformation. Purely mechanical compaction originates mainly from pore fluid expulsion and rearrangement of solid particles during burial, while chemo‐mechanical compaction results from Intergranular Pressure‐Solution (IPS) and represents a major mechanism of deformation in sedimentary basins during diagenesis. The aim of the present contribution is to provide a comprehensive 3D framework for constitutive and numerical modeling of purely mechanical and chemo‐mechanical compaction in sedimentary basins. Extending the concepts that have been previously proposed for the modeling of purely mechanical compaction in finite poroplasticity, deformation by IPS is addressed herein by means of additional viscoplastic terms in the state equations of the porous material. The finite element model integrates the poroplastic and poroviscoplastic components of deformation at large strains. The corresponding implementation allows for numerical simulation of sediments accretion/erosion periods by progressive activation/deactivation of the gravity forces within a fictitious closed material system. Validation of the numerical approach is assessed by means of comparison with closed‐form solutions derived in the context of a simplified compaction model. The last part of the paper presents the results of numerical basin simulation performed in one dimensional setting, demonstrating the ability of the modeling to capture the main features in elastoplastic and viscoplastic compaction. Copyright © 2016 John Wiley & Sons, Ltd.     

Geography in a restructuring world?

In those parts of their discipline which can be categorised as spatial analysis, geographers have focused attention on distance as a key variable, and have paid little attention to bounded spaces and territoriality strategies. In a rapidly restructuring world, in which distance is becoming increasingly irrelevant as an influence on many forms of behaviour, territoriality remains an important aspect of the manipulation of space for economic, social, political and cultural purposes: in the terminology of Hagerstrands classic model, while the coupling and capability constraints on interaction are weakening, the authority constraint remains strong.