基于网络药理学探究补阳还五汤治疗颈椎病的作用机制

目的：基于网络药理学与分子对接技术分析补阳还五汤治疗颈椎病的作用机制。方法：使用TCMSP、化学专业数据库获取补阳还五汤的活性成分,并对潜在靶点进行预测及规范。分别从PharmGKB、DisGeNET、OMIM、GeneCards数据库中得到颈椎病疾病靶点,利用韦恩图获取补阳还五汤与颈椎病的交集靶点。通过CytoScape软件构建中药-活性成分-疾病靶点和蛋白质-蛋白质相互作用（PPI）网络,获得核心有效成分与关键靶点,利用David数据库对潜在靶点进行富集分析。最后运用AutoDock Vina软件对补阳还五汤核心有效成分与关键靶点进行分子对接验证。结果：共获得补阳还五汤治疗颈椎病的有效活性成分97个,包括槲皮素、山柰酚、黄芩素、木犀草素等;交集靶点64个,关键靶点有白细胞介素-6（IL-6）、肿瘤坏死因子（TNF）、丝氨酸/苏氨酸蛋白激酶1（AKT1）、白细胞介素-1B（IL-1B）等;主要涉及肿瘤坏死因子（TNF）、白细胞介素-17（IL-17）、磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（Akt）等信号通路,分子对接结果显示核心有效成分与关键靶点之间结合紧密,为补阳还五汤治疗颈椎病提供相应条件。结论：该研究在总体上预测了补阳还五汤治疗颈椎病的活性成分、靶点和信号通路,作用途径广泛,为下一步的临床应用提供参考及思路。     

Geomorphological evidence for upslope canyon-forming processes on the northern KwaZulu-Natal shelf,SW Indian Ocean,South Africa

A geomorphological and statistical analysis of slope canyons from the northern KwaZulu-Natal continental margin is documented and compared with submarine canyons from the Atlantic margin of the USA. The northern KwaZulu-Natal margin is characterized by increasing upslope relief, concave slope-gradient profiles and features related to upslope growth of the canyon forms. Discounting slope-gradient profile, this morphology is strikingly similar to canyon systems of the New Jersey slope. Several phases of canyon incision indicate that downslope erosion is also an important factor in the evolution of the northern KwaZulu-Natal canyon systems. Despite the strong similarities between the northern KwaZulu-Natal and New Jersey slope-canyon systems, key differences are evident: (1) the concavity of the northern KwaZulu-Natal slope, contrasting with the ∼linear New Jersey slope; (2) the relative isolation of the northern KwaZulu-Natal canyons, rather than the dense clustering of the New Jersey canyons; and (3) the absence of strongly shelf-breaching canyons along the northern KwaZulu-Natal margin. In comparison with the New Jersey margin, we surmise a more youthful stage of canyon evolution, a result of either the canyons themselves being younger or the formative processes being less active. Less complicated patterns of erosion resulting from reduced sediment availability have developed in northern KwaZulu-Natal. The reduction in slope concavity on the New Jersey margin may be the result of grading of the upper slope by intensive headward erosion, a process more subdued—or less evident—on the KwaZulu-Natal margin.     

A new type of Shipboard Meteorological Satellite Receiving-processing System

INTRODUCTIONTheSMSRPSisstalledontheshipnavigatingovertheseaandreceivessatellitecloudmapsatanytimetoprovidereliablereal-timedataofmeteorologyandocean.Itisanimportantequipmentforsafeguardofshipnavigation.Chinahasthousandsofoceanicships.Butalmostallships,withonlyveryfewexception,arenotstalledbySMSRPS.Thecausesareasfollows:1.Thetechniqueisverycomplicated.2.Thedevelopmentcostisveryhigh.3.Ifweintroduceforeignequipment,thecostistooexpensive.4.Foreignequipmentanditssoftwarearecompletelyclo…     

利用卫星遥感资料对南海北部陆架海洋表层温度锋的分析

利用7年(1993～1999)月平均的SST卫星遥感资料，分析了南海北部陆架区域海洋表层温度锋在一年中的逐月变化特征，表明南海北部陆架海洋表层温度锋存在明显的季节内变化。结合风场的卫星遥感资料，分析了东北季风对南海北部陆架温度锋的影响，表明东北季风风速的增加有利于温度锋强度的增强。通过对黑潮南海流套入侵较强的1999年2月与流套入侵较弱的1998年2月的SST卫星遥感资料的对比分析，考察了黑潮南海流套的入侵对南海北部陆架温度锋的影响，结果表明黑潮流套的较强入侵能够增加陆架温度锋的强度，对温度锋的走向也会产生一定的影响。     

哀牢山-红河断裂带中段应变分析

对哀牢山—红河断裂带中段和平—水塘剖面、墨江—元江剖面和其它地段的岩石应变及磁组构进行了分析，表明应变强度的校正磁各向异性度PJ从断裂带向西至三叠系明显降低，变形强度向西迅速减弱。磁化率椭球体主轴展布反映出剪切带内、外变形方式的改变。剪切带内，以水平走滑运动为主；向西则以水平缩短为主。在应变分析中，对断裂带内的S—C组构两组面理夹角、杏仁体和石榴石应变标志体进行了测量，结果显示，剪切带内的磁组构和岩石组构间关系较差。此外，还对这两条剖面中的三叠系进行了应变和磁组构分析，找出了它们与磁化率椭球体对应轴率间的相关性。     

A study on the polarimetric properties of various features using SIR-C data

Spaceborne Imaging Radar (SIR-C) data acquired over Gujarat, India in 1994 were processed and analysed using differnet techniques applicable to polarimetric SAR data such as polarization signatures, polarization index, decomposition of the signal and polarization phase difference and limited groundtruth data. It has been observed that multi-frequency polarimetric data enhances the potential of retrieving geo-physical parameters. The polarization signatures are found to vary with the nature of the target. Target decomposition of the returned signal will be useful for the classification of various features. Polarization Phase Difference (PPD) gives good information about the vegetation parameters.     

GPS signal acquisition using the repeatability of successive code phase measurements

This paper introduces a new method for GPS signal acquisition, which is based on the repeatability of successive code phase measurements and the M-of-N search algorithm. The performance of the proposed method in terms of probability of signal detection is similar to that of traditional methods, except that the calculation of the probability of detection does not rely on the noise distribution or the Carrier-to-Noise ratio (C/N₀). The code phase repeatability-based method is presented along with equations for probability of detection and probability of false detection. If the distribution of the noise is known, it also provides an estimate of the C/N₀. The proposed method is illustrated for coherent and non-coherent acquisition and C/N₀ estimation.     

Mirdita Zone ophiolites and associated sediments in Albania reveal Neotethys Ocean origin

The Mirdita Ophiolite Zone in Albania is associated with widespread mélanges containing components of up to nappe-size. We dated matrix and components of the mélange by radiolarians, conodonts, and other taxa. The components consist of radiolarites, pelagic limestones and shallow-water limestones, all of Triassic age, as well as ophiolites. Triassic radiolarite as a primary cover of ophiolite material proves Middle Triassic onset of Mirdita ocean-floor formation. The mélange contains a turbiditic radiolarite-rich matrix (“radiolaritic flysch”), dated as Late Bajocian to Early Oxfordian. It formed as a synorogenic sediment during west-directed thrusting of ophiolite and sediment-cover nappes representing ocean floor and underplated fragments of the western continental margin. The tectonic structures formed during these orogenic events (“Younger Kimmeridian or Eohellenic Orogeny”) are sealed by Late Jurassic platform carbonates. The geological history conforms with that of the Inner Dinarides and adjoining areas; we therefore correlate the Mirdita-Pindos Ophiolite Zone with the Vardar Zone and explain its present position by far-distance west-directed thrusting.