单环刺螠纤溶酶UFEⅠ药效作用和免疫原性的初步研究

为评价单环刺螠纤溶酶(UFEⅠ)的抗凝血和抗血栓形成作用,并对其免疫原性进行初步研究.文中通过小鼠血液凝固时间实验和大鼠颈动脉血栓形成模型研究UFE Ⅰ抗凝血和抗血栓作用.用纯UFE Ⅰ为抗原免疫小鼠,间接ELISA法测定特异性抗体的动态变化及效价.结果UFE Ⅰ能明显延长小鼠凝血时间,有效抑制大鼠体内的血栓形成,并显著降低大鼠纤维蛋白原含量(FIB),延长活化部分凝血活酶时间(APTT).免疫原性的研究结果为UFE Ⅰ末次免疫小鼠后,产生微量特异性抗体,且抗体水平呈现先升后降的动态变化;方阵法确定了ELISA的优化条件,测定UFE Ⅰ免疫后产生的抗体效价为1∶1 280.本文研究显示,单环刺螠纤溶酶UFEⅠ具有显著的抗凝血和抗血栓形成作用,在小鼠体内产生一过性抗体,但对动物机体不造成负面影响.     

海洋平肝潜阳中药石决明对血管紧张素转化酶抑制作用研究

为研究海洋平肝潜阳中药石决明的降血压活性,采用高效液相色谱法,体外测定石决明对血管紧张素转化酶(ACE)的抑制作用。以马尿酰-组氨酰-亮氨酸为反应底物,血管紧张素转化酶为催化剂,反应所生成的马尿酸为测定指标,未加酶抑制剂的反应为空白对照。采用Waters C18色谱柱,以乙腈-水为流动相梯度洗脱,流速0.6mL·min-1,检测波长228nm,进样量10μL;马尿酸在0.005～1.000mmol·L-1范围内呈良好的线性关系(R2=0.999 9),最低检测限为0.2μmol·L-1,对马尿酸的回收率范围为95.0%～102.8%。将方法应用于海洋中药石决明的ACE抑制活性测定,其IC50值为49.20mg·mL-1。本研究为石决明治疗肝阳上亢型高血压的机制和有效成分的深入探讨提供一定依据。     

Evaluation and fusion of SST data from MTSAT and TMI in East China Sea, Yellow Sea and Bohai Sea in 2008

Two typical satellite sea surface temperature (SST) datasets, from the Multi-functional Transport Satellite (MTSAT) and Tropical Rainfall Measuring Mission Microwave Imager (TMI), were evaluated for the East China Sea, Yellow Sea, and Bohai Sea throughout 2008. Most monthly-mean availabilities of MTSAT are higher than those of TMI, whereas the seasonal variation of the latter is less than that of the former. The analysis on the one-year data shows that the annual mean availability of MTSAT (61%) is greater than that of TMI (56%). This is mainly because MTSAT is a geostationary satellite, which achieves longer observation than the sun-synchronous TMI. The daily availability of TMI (28%-75%) is more constant than that of MTSAT (9%-93%). The signal of infrared sensors on MTSAT is easily disturbed on cloudy days. In contrast, the TMI microwave sensor can obtain information through clouds. Based on in-situ SSTs, the SST accuracy of TMI is superior to that of MTSAT. In 2008, the root mean square (RMS) error of TMI and MTSAT were 0.77 K and 0.84 K, respectively. The annual mean biases were 0.14 K (TMI) and -0.31 K (MTSAT). To attain a high availability of SSTs, we propose a fusion method to merge both SSTs. The annual mean availability of fusion SSTs increases 17% compared to MTSAT. In addition, the availabilities of the fusion SSTs become more constant. The annual mean RMS and bias of fusion SSTs (0.78 K and -0.06 K, respectively) are better than those of MTSAT (0.84 K and -0.31 K).     

Effects of spectral nudging on the 2010 East Asia summer monsoon using WRF model

The performance of spectral nudging in an investigation of the 2010 East Asia summer monsoon was assessed using the Weather Research and Forecasting (WRF) model, forced by 1-degree NCEP Global Final Analysis (FNL). Two pairs of experiments were made, spectral nudging (SP) and non-spectral nudging (NOSP), with five members in each group. The members were distinguished by different initial times, and the analysis was based on the ensemble mean of the two simulation pairs. The SP was able to constrain error growth in large-scale circulation in upper-level, during simulation, and generate realistic regional scale patterns. The main focus was the model ability to simulate precipitation. The Tropical Rainfall Measuring Mission (TRMM) 3B42 product was used for precipitation verification. Mean precipitation magnitude was generally overestimated by WRF. Nevertheless, SP simulations suppressed overestimation relative to the NOSP experiments. Compared to TRMM, SP also improved model simulation of precipitation in spatial and temporal distributions, with the ability to reproduce movement of rainbands. However, extreme precipitation events were suppressed in the SP simulations.     

支持多种模糊处理的英文智能预提示输入引擎

提出并实现了一种基于离散、交叉、非完全字符串匹配技术的英文智能预提示输入引擎,并集成为动态链接库。引擎主要特点是可以提供多种英文预提示输入模式设置,根据用户输入的检索词,对单词相似性、单词频度、输入前文等因素,进行相关度综合计算,从词库中按相关度由高到低输出N个英文单词或短语,供用户选择。引擎解决了英文输入方式单一的问题,为用户提供多种模糊输入方式选择以及更加综合的智能预提示效果;同时,作为一种共性基础技术集成为动态链接库,可以简化各种软件产品中英文预提示输入的设计,降低工程复杂性,缩短设计周期,提升产品的英文预提示输入的智能处理水平。     

粒子群优化的半监督入侵检测算法

为解决无监督入侵检测算法检测率低,有监督的入侵检测不能有效的检测未知攻击的问题,提出了一种粒子群优化的半监督入侵检测算法,算法对少量的约束信息进行基于密度的扩展获得潜在约束得到聚类模型,以此指导未标记数据聚类,对仍没有确定类别的未标示数据使用粒子群优化的K均值算法进行聚类实现对异常的检测。改进的算法检测率达到83.7%,误报率减少至3.13%,总体效果优于无监督和有监督学习的入侵检测算法。     

针铁矿和蒙脱石对菲的吸附解吸行为与热力学研究

采用批量振荡吸附平衡法设计针铁矿和蒙脱石对菲的吸附解吸试验,对比研究了针铁矿和蒙脱石对菲的吸附解吸行为,并考察了不同K+浓度的溶液对蒙脱石吸附菲的影响,比较分析了线性吸附模型和Freundlich吸附模型描述矿物吸附等温线的准确性,并从吸附热力学角度探讨了矿物的吸附机理。结果表明:针铁矿和蒙脱石对菲的吸附解吸均表现出明显的非线性和解吸滞后现象;相对于线性吸附模型来说,针铁矿和蒙脱石对菲的吸附解吸更符合Freundlich吸附模型;与蒙脱石相比,针铁矿对菲的吸附更为显著,且具有更好的稳定性;溶液中软阳离子K+的存在使蒙脱石对菲的吸附能力得到显著提高;菲在蒙脱石和针铁矿上的吸附过程是一个自发放热,同时伴随着熵值减小的过程;随着温度的升高,蒙脱石和针铁矿对菲的吸附能力均减弱。     

平邑县石膏矿山地质环境保护与治理

平邑县矿产资源丰富,但多年的开采破坏了周围的生态环境。为此,平邑县高度重视矿山地质环境的保护与治理工作,在分析石膏矿区地质环境现状的基础上,针对不同开采方式的矿山提出了相应的治理措施,矿山地质环境保护与治理取得了显著成效。     

辽宁板块构造特征及大地构造单元划分

利用板块构造理论,依据近年来1：5万区域地质调查及相关科研成果,对辽宁地壳发展演化进行了分析研究,提出辽宁地壳发展可暂划分为早前寒武纪大陆增生构造体制和中元古宙以来的板块构造体制.中太古代-古元古代发现了绿岩地体和古元古宙裂谷,因此将早前寒武纪视作原始板块,中元古代-古生代视作古板块,中生代以来视作现代板块.在此基础上对辽宁大地构造单元进行了划分.辽宁Ⅰ级构造单元为塔里木-华北板块.Ⅱ级构造单元为天山-赤峰陆缘活动带和华北陆块.Ⅲ级构造单元5个,分别为建平-西丰华力西陆缘造山带、冀辽地块、铁岭-清原微地块、辽吉地块及下辽河-辽东湾新生代裂谷.Ⅳ级构造单元16个.为清楚地了解辽宁地壳发展演化特点,对5个Ⅲ级构造单元地质特征进行简要阐述.     

Petrography,mineralogy, and geochemistry of lunar meteorite Sayh al Uhaymir 300

Abstract— We report here the petrography, mineralogy, and geochemistry of lunar meteorite Sayh al Uhaymir 300 (SaU 300). SaU 300 is dominated by a fine‐grained crystalline matrix surrounding mineral fragments (plagioclase, pyroxene, olivine, and ilmenite) and lithic clasts (mainly feldspathic to noritic). Mare basalt and KREEPy rocks are absent. Glass melt veins and impact melts are present, indicating that the rock has been subjected to a second impact event. FeNi metal and troilite grains were observed in the matrix. Major element concentrations of SaU 300 (Al₂O₃ 21.6 wt% and FeO 8.16 wt%) are very similar to those of two basalt‐bearing feldspathic regolith breccias: Calcalong Creek and Yamato (Y‐) 983885. However, the rare earth element (REE) abundances and pattern of SaU 300 resemble the patterns of feldspathic highlands meteorites (e.g., Queen Alexandra Range (QUE) 93069 and Dar al Gani (DaG) 400), and the average lunar highlands crust. It has a relatively LREE‐enriched (7 to 10 x CI) pattern with a positive Eu anomaly (?11 x CI). Values of Fe/Mn ratios of olivine, pyroxene, and the bulk sample are essentially consistent with a lunar origin. SaU 300 also contains high siderophile abundances with a chondritic Ni/Ir ratio. SaU 300 has experienced moderate terrestrial weathering as its bulk Sr concentration is elevated compared to other lunar meteorites and Apollo and Luna samples. Mineral chemistry and trace element abundances of SaU 300 fall within the ranges of lunar feldspathic meteorites and FAN rocks. SaU 300 is a feldspathic impact‐melt breccia predominantly composed of feldspathic highlands rocks with a small amount of mafic component. With a bulk Mg# of 0.67, it is the most mafic of the feldspathic meteorites and represents a lunar surface composition distinct from any other known lunar meteorites. On the basis of its low Th concentration (0.46 ppm) and its lack of KREEPy and mare basaltic components, the source region of SaU 300 could have been within a highland terrain, a great distance from the Imbrium impact basin, probably on the far side of the Moon.