Lysosomal injury and MFO activity in the liver of flounder (Platichthys flesus L.) in relation to histopathology of hepatic degeneration and carcinogenesis

Flounder (Platichthys flesus L.), 18–48 cm total length were sampled in the mouth of the Elbe River during a 3-year interdisciplinary project ‘Fish Diseases in the Wadden Sea’. Lysosomal changes (lysosomal membrane stability) and the activity of biotransforming enzymes (MFOs/EROD) were measured parallel to investigations of ultrastructural changes in liver cells, tissue pathologies and macroscopically visible changes. The aim of the study was to investigate if these cyto- and biochemical parameters were able to reflect contaminant induced biological effects. Interlinking of the results of the MFO activity to the pathological alterations observed at the electron- and light-microscopic levels as well as during macroscopic inspection of identical individuals evidenced that the activity of the biotransformation enzymes (EROD) was not induced in healthy livers, increased considerably with the onset of liver changes and dropped again in those livers with degenerative, preneoplastic and neoplastic lesions. In contrast, concurrent studies of lysosomal membrane stability measured in parallel showed a decrease with the onset and progression of liver lesions from reversible to irreversible, neoplastic change.     

积雪变化导致格陵兰冰盖高度变化

地面冰盖对气候变化的反应可能会对未 来的海平面变化产生重大的影响.近年来格 陵兰南部的卫星调查显示,较大高度的冰盖 总体高度变化甚小,但空间变化很大.当然 仅仅依靠卫星数据难以测定是什么地球物理 过程引起了这种高度变化以及近年的变化速 率是否超过了正常变化速率.我们利用雪粒 密度增大的物理模型和根据高海拔12个冰 心再造的年雪堆积记录,获取了1978～1988 年格陵兰南部冰盖高度的变化. 地中海的干涸及其产生的后果 К.Н. Несис 很久以来就知道,地史最后阶段最具戏 剧性的事件之一就是大约在6Ma前的中新 世末期地中海的被隔离和完全干涸.据西西 里岛墨西拿城附近该时期著名的沉积剖面, 这个事件被称之为墨西拿盐量转变. 马建华摘译自 , 2000, Vol.406,No.24 周立君校