壳聚糖在药物缓释中的研究进展

壳聚糖也称甲壳胺或几丁聚糖壳聚糖,是一种天然聚阳离子碱性多糖,其化学名称为(1,4)-2-氨基-2-脱氧-β-D-葡聚糖,是甲壳素脱乙酰基的产物,而甲壳素是虾、蟹等甲壳动物外壳的主要成分,广泛存在于自然界。壳聚糖具有很好的生物相容性和生物可降解性,且其降解产物对人体健康无害,近年来在药物制剂中的应用越来越广泛,作者就壳聚糖在药物缓释、控释中的应用研究进展作一综述。1壳聚糖的药理作用1.1壳聚糖的药理特性壳聚糖及其衍生物是来源于海洋的天然高分子化合物,是天然的动物性食物纤维,是自然界存在的惟一一种碱性多糖,壳聚糖的基本结构单…     

Late mesozoic A-Type granitoids in se China and paleo-pacific plate subduction and slab rollback北大核心CSCD

This study has reviewed the distribution and pedogenesis of late Mesozoic A-Type granitoids in SE China. These A-Type granitoids belong to four belts ( S Jiangxi-SW Fujian belt, Xiang-Gui-Yue belt, Can-Hang belt and coastal belt) due to their temporal-spatial distribution. Based on the comparative analysis of chronology, geochemistry and magmatic association, this study has discussed the formation of A-Type granitoids and the subduction and slab rollback process of paleo-Pacific plate beneath SE China.     

高煤级煤粗粒体反射率的演化轨迹

通过系统测试，查明了镜质体油浸最大反射率在２．０％～１０．０％之间的样品中粒粒体反射率的演化轨迹，发现其最大反射率的演化具有“转折”特征。粗粒体化学结构的“非石墨化碳”性质、物理结构的“富微孔性”及构造应力的作用是控制反射率演化的主要因素。     

编者按

<正>三峡工程举世瞩目,是长江流域大保护与流域水安全保障的关键性枢纽工程。自2003年三峡工程蓄水以来,在防洪、发电、航运、供水等方面产生了巨大的经济、社会及生态环境等综合效益。同时,水库建成后,重庆至宜昌600多km的自然河道变成了人为控制的大型河流型深水水库,不仅在库区形成了诸如消落带、干-支流往复交融的独特生境,而且由于下泄水流、泥沙、营养盐等水文及生物地球化学要素的时空变化,     

腾格里沙漠地区盐湖资源调查遥感应用研究

通过对腾格里沙漠地区遥感影像信息分析与野外实地调查,圈定出大小盐湖122个,查明了盐湖的空间分布规律,划分了图兰泰湖-头道湖、白碱湖-西硝池、苏武山湖-汤家海、鸡龙同古-和屯、通古楼诺尔-巴彦达来五个盐湖分布区,对各分布区盐湖的成因类型、沉积特征、成矿规律及资源状况进行了研究,为进一步勘查、开发和利用本区资源提供了依据。     

Characterization,dissolution and solubility of the hydroxypyromorphite–hydroxyapatite solid solution [(Pb<Subscript>x</Subscript>Ca<Subscript>1−x</Subscript>)<Subscript>5</Subscript>(PO<Subscript>4</Subscript>)<Subscript>3</Subscript>OH] at 25 °C and pH 2–9

Background

The interaction between Ca-HAP and Pb²⁺ solution can result in the formation of a hydroxyapatite–hydroxypyromorphite solid solution [(Pb_xCa_1?x)₅(PO₄)₃(OH)], which can greatly affect the transport and distribution of toxic Pb in water, rock and soil. Therefore, it’s necessary to know the physicochemical properties of (Pb_xCa_1?x)₅(PO₄)₃(OH), predominantly its thermodynamic solubility and stability in aqueous solution. Nevertheless, no experiment on the dissolution and related thermodynamic data has been reported.

Results

Dissolution of the hydroxypyromorphite–hydroxyapatite solid solution [(Pb_xCa_1?x)₅(PO₄)₃(OH)] in aqueous solution at 25 °C was experimentally studied. The aqueous concentrations were greatly affected by the Pb/(Pb + Ca) molar ratios (X_Pb) of the solids. For the solids with high X_Pb [(Pb_0.89Ca_0.11)₅(PO₄)₃OH], the aqueous Pb²⁺ concentrations increased rapidly with time and reached a peak value after 240–720 h dissolution, and then decreased gradually and reached a stable state after 5040 h dissolution. For the solids with low X_Pb (0.00–0.80), the aqueous Pb²⁺ concentrations increased quickly with time and reached a peak value after 1–12 h dissolution, and then decreased gradually and attained a stable state after 720–2160 h dissolution.

Conclusions

The dissolution process of the solids with high X_Pb (0.89–1.00) was different from that of the solids with low X_Pb (0.00–0.80). The average K _sp values were estimated to be 10^?80.77±0.20 (10^?80.57–10^?80.96) for hydroxypyromorphite [Pb₅(PO₄)₃OH] and 10^?58.38±0.07 (10^?58.31–10^?58.46) for calcium hydroxyapatite [Ca₅(PO₄)₃OH]. The Gibbs free energies of formation (ΔG _f ^o ) were determined to be ?3796.71 and ?6314.63 kJ/mol, respectively. The solubility decreased with the increasing Pb/(Pb + Ca) molar ratios (X_Pb) of (Pb_xCa_1?x)₅(PO₄)₃(OH). For the dissolution at 25 °C with an initial pH of 2.00, the experimental data plotted on the Lippmann diagram showed that the solid solution (Pb_xCa_1?x)₅(PO₄)₃(OH) dissolved stoichiometrically at the early stage of dissolution and moved gradually up to the Lippmann solutus curve and the saturation curve for Pb₅(PO₄)₃OH, and then the data points moved along the Lippmann solutus curve from right to left. The Pb-rich (Pb_xCa_1?x)₅(PO₄)₃(OH) was in equilibrium with the Ca-rich aqueous solution.

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Graphical abstractLippmann diagrams for dissolution of the hydroxypyromorphite–hydroxyapatite solid solution [(Pb_xCa_1?x)₅(PO₄)₃OH] at 25??C and an initial pH of 2.00.

     

应用AMSU资料监测中国地区雪盖的初步研究

根据微波遥感积雪的原理, 提出了利用NOAA-16 AMSU的1通道 (23.8 GHz)、2通道 (31.4 GHz) 和15通道 (89.0 GHz) 等3个通道监测中国五大区域雪盖范围的初步判识方法。由该方法制作合成了2001年10月1日至2002年4月1日中国地区的周积雪覆盖监测图, 与来自全国气象台站的地面积雪观测记录以及美国人机交互式冰雪制图系统 (I nteractive Snow and Ice Mapping System, IMS) 的雪盖图、SSM/ I (Special Sensor Microwave Imager) 雪盖图的比较结果表明:AMSU监测结果不仅具有比较高的准确性, 而且其准确性和可靠性达到甚至优于其它两种积雪监测结果 (尤其是雪季中期)。     

Diurnal Variations of Hydrochemistry in a Travertine-depositing Stream at Baishuitai, Yunnan, SW China

Diurnal variations of hydrochemistry were monitored at a spring and two pools in a travertine-depositing stream at Baishuitai, Yunnan, SW China. Water temperature, pH and specific conductivity were measured in intervals of 5 and 30 min for periods of 1 to 2 days. From these data the concentrations of Ca²⁺, HCO₃⁻, calcite saturation index, and CO₂ partial pressure were derived. The measurements in the spring of the stream did not show any diurnal variations in the chemical composition of the water. Diurnal variations, however, were observed in the water of the two travertine pools downstream. In one of them, a rise in temperature (thus more CO₂ degassing) during day time and consumption of CO₂ due to photosynthesis of submerged aquatic plants accelerated deposition of calcite, whereas in the other pool, where aquatic plants flourished and grew out of the water (so photosynthesis was taking place in the atmosphere), the authors suggest that temperature-dependent root respiration underwater took place, which dominated until noon. Consequently, due to the release of CO₂ by the root respiration into water, which dominated CO₂ production by degassing induced by temperature increase, the increased dissolution of calcite was observed. This is the first time anywhere at least in China that the effect of root respiration on diurnal hydrochemical variations has been observed. The finding has implications for sampling strategy within travertine-depositing streams and other similar environments with stagnant water bodies such as estuaries, lakes, reservoirs, pools and wetlands, where aquatic plants may flourish and grow out of water.     

地球内核快速旋转的发现与全球变化的轨道效应

科里奥利效应是产生内核快速旋转的主要原因。科氏力使上升物质向西漂移，下降物质向东漂移；造成地球外层自转减速，地球内层自转加速。所以，自旋体中的垂直运动可以产生大规模的水平运动——圈层差异旋转。地震波测量结果表明，内核旋转速度每年比地壳地幔快１°。对于一个内核差异旋转的地球，太阳辐射不仅形成地磁场的内外磁尾和地壳与内核的反向振动，而且影响核幔角动量交换和电磁耦合，从而控制了地球内能的释放，形成天文周期与地质旋回的一一对应关系。地球轨道和太阳轨道的全球变化响应，为太阳辐射量变化控制地球内能释放提供了证据     

机载条纹管成像激光雷达在拍岸区探测水雷

为了解决拍岸区水雷探测的问题,以无人机为载体的条纹管成像蓝绿激光雷达可以用来扫描、识别水雷,蓝绿激光成像雷达白天和夜晚均可以稳定成像,机载探测方式相对于水下、水面等传统探测方式效率也可以提高,机载激光雷达可由小型船舶、小型汽车等多平台携带使用。