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Effects of sulfate chitosan derivatives on nonalcoholic fatty liver disease

Sulfate chitosan derivatives have good solubility and therapeutic effect on the cell model of NAFLD. The aim of this study was to examine the therapeutic effect of sulfate chitosan derivatives on NAFLD. The male Wistar rats were orally fed high fat emulsion and received sulfate chitosan derivatives for 5 weeks to determine the pre-treatment effect of sulfate chitosan derivatives on NAFLD. To evaluate the therapeutic effect of sulfate chitosan derivatives on NAFLD, the rats were orally fed with high concentration emulsion for 5 weeks, followed by sulfate chitosan derivatives for 3 weeks. Histological analysis and biomedical assays showed that sulfate chitosan derivatives can dramatically prevent the development of hepatic steatosis in hepatocyte cells. In animal studies, pre-treatment and treatment with sulfate chitosan derivatives significantly protected against hepatic steatohepatitis induced by high fat diet according to histological analysis. Furthermore, increased TC, ALT, MDA, and LEP in NAFLD were significantly ameliorated by pre-treatment and treatment with sulfate chitosan derivatives. Furthermore, increased TG, AST, and TNF-α in NAFLD were significantly ameliorated by treatment with sulfate chitosan derivatives. Sulfate chitosan derivatives have good pre-treatment and therapeutic effect on NAFLD.     

Evaluation of three harvest control rules for Bigeye Tuna (Thunnus obesus) fisheries in the Indian Ocean

The stock of Bigeye tuna(Thunnus obesus) in the Indian Ocean supports an important international fishery and is considered to be fully exploited. The responsible management agency, the Indian Ocean Tuna Commission(IOTC), does not have an explicit management decision-making framework in place to prevent over-fishing. In this study, we evaluated three harvest control rules, i) constant fishing mortality(CF), from 0.2 to 0.6, ii) constant catch(CC), from 60000 to 140000 t, and iii) constant escapement(CE), from 0.3 to 0.7. The population dynamics simulated by the operating model was based on the most recent stock assessment using Stock Synthesis version Ⅲ(SS3). Three simulation scenarios(low, medium and high productivity) were designed to cover possible uncertainty in the stock assessment and biological parameters. Performances of three harvest control rules were compared on the basis of three management objectives(over 3, 10 and 25 years): i) the probability of maintaining spawning stock biomass above a level that can sustain maximum sustainable yield(MSY) on average, ii) the probability of achieving average catches between 0.8 MSY and 1.0 MSY, and iii) inter-annual variability in catches. The constant escapement strategy(CE=0.5), constant fishing mortality strategy(F=0.4) and constant catch(CC=80000) were the most rational among the respective management scenarios. It is concluded that the short-term annual catch is suggested at 80000 t, and the potential total allowable catch for a stable yield could be set at 120000 t once the stock had recovered successfully. All the strategies considered in this study to achieve a ‘tolerable' balance between resource conservation and utilization have been based around the management objectives of the IOTC.     

长江口及其邻近陆架区夏季网采浮游植物及其影响因素

2009年6、8月长江口及其邻近陆架区的网采样品中检出浮游植物9门395种(含223种硅藻与125种甲藻)。浮游植物丰度8月(3 077.15×104 cells/m3)显著高于6月(107.80×104 cells/m3)。随长江冲淡水势力增强,位于长江口的丰度高值区8月较6月更偏外侧。种类丰富度8月高于6月,但多样性和均匀度指数略低于6月。6月尖刺伪菱形藻和三角角藻占绝对优势,8月优势种主要有尖刺伪菱形藻、笔尖形根管藻和铁氏束毛藻。骨条藻虽非优势种,但在长江冲淡水区丰度较高。相似性分析和多维尺度分析表明,浮游植物群落组成时空差异显著。典范对应分析表明,温度和盐度是分别影响6、8月群落分布的首要因子。根据水动力和化学参数,该区浮游植物群落分布与环流变化和水团消长密切相关。     

基于ROMS模式利用集合最优插值同化沿轨海表面高度异常数据的研究

The ensemble optimal interpolation （EnOI） is applied to the regional ocean modeling system （ROMS） with the ability to assimilate the along-track sea level anomaly （TSLA）. This system is tested with an eddy-resolving system of the South China Sea （SCS）. Background errors are derived from a running seasonal ensemble to account for the seasonal variability within the SCS. A fifth-order localization function with a 250 km localization radius is chosen to reduce the negative effects of sampling errors. The data assimilation system is tested from January 2004 to December 2006. The results show that the root mean square deviation （RMSD） of the sea level anomaly decreased from 10.57 to 6.70 cm, which represents a 36.6% reduction of error. The data assimilation reduces error for temperature within the upper 800 m and for salinity within the upper 200 m, although error degrades slightly at deeper depths. Surface currents are in better agreement with trajectories of surface drifters after data assimilation. The variance of sea level improves significantly in terms of both the amplitude and position of the strong and weak variance regions after assimilating TSLA. Results with AGE error （AGE） perform better than no AGE error （NoAGE） when considering the improvements of the temperature and the salinity. Furthermore, reasons for the extremely strong variability in the northern SCS in high resolution models are investigated. The results demonstrate that the strong variability of sea level in the high resolution model is caused by an extremely strong Kuroshio intrusion. Therefore, it is demonstrated that it is necessary to assimilate the TSLA in order to better simulate the SCS with high resolution models.     

2013年海洋和大气环流异常及对中国气候的影响

本文对2013年海洋和大气环流异常特征进行分析,讨论这些异常特征对中国气温和降水的主要影响。结果表明：2012/2013年冬季,北极涛动持续维持负位相,500 hPa位势高度场上,欧亚大陆中高纬环流呈“两槽一脊”的环流形势,乌拉尔山的高压脊持续偏强,而东亚槽也异常偏强,导致全国平均气温较常年同期偏低。季内,西伯利亚高压强度变化显著,与之相对应,我国气温季内阶段性变化大,前冬冷、后冬暖。进一步研究表明,前秋北极海冰的大幅偏少是造成东亚冬季风偏强的重要原因。2013年冬季至夏季,赤道中东太平洋海温异常偏低而海洋性大陆至西太平洋海温异常偏高,受此影响,夏季西太平洋副热带高压位置明显偏北,导致我国北方夏季多雨。与此同时,受西太平洋副热带高压下沉气流的控制,我国南方大部高温持续。2013年南海夏季风爆发偏早两候,结束偏晚4候,强度偏弱。     

Fusion of high-resolution DEMs derived from COSMO-SkyMed and TerraSAR-X InSAR datasets

Voids caused by shadow, layover, and decorrelation usually occur in digital elevation models (DEMs) of mountainous areas that are derived from interferometric synthetic aperture radar (InSAR) datasets. The presence of voids degrades the quality and usability of the DEMs. Thus, void removal is considered as an integral part of the DEM production using InSAR data. The fusion of multiple DEMs has been widely recognized as a promising way for the void removal. Because the vertical accuracy of multiple DEMs can be different, the selection of optimum weights becomes a key problem in the fusion and is studied in this article. As a showcase, two high-resolution InSAR DEMs near Mt. Qilian in northwest China are created and then merged. The two pairs of InSAR data were acquired by TerraSAR-X from an ascending orbit and COSMO-SkyMed from a descending orbit. A maximum likelihood fusion scheme with the weights optimally determined by the height of ambiguity and the variance of phase noise is adopted to syncretize the two DEMs in our study. The fused DEM has a fine spatial resolution of 10 m and depicts the landform of the study area well. The percentage of void cells in the fused DEM is only 0.13 %, while 6.9 and 5.7 % of the cells in the COSMO-SkyMed DEM and the TerraSAR-X DEM are originally voids. Using the ICESat/GLAS elevation data and the Chinese national DEM of scale 1:50,000 as references, we evaluate vertical accuracy levels of the fused DEM as well as the original InSAR DEMs. The results show that substantial improvements could be achieved by DEM fusion after atmospheric phase screen removal. The quality of fused DEM can even meet the high-resolution terrain information (HRTI) standard.