高速铁路隧道围岩抗力系数现场试验与理论研究

以沪昆高速铁路隧道为依托,通过现场径向液压枕试验,测量各级压力下半径向变形,获取了隧道研究点处岩石抗力系数实测值。在实测数据的基础上,结合国内外相关的弹性抗力本构模型,建立了沪昆高速铁路隧道围岩抗力系数的5种理论计算模型：理想弹塑性模型、爆破裂缝弹塑性模型、塑性软化岩体模型、Lade-Duncan准则模型、统一强度理论模型,并有针对性的将所研究的20座隧道进行分类,分别计算其围岩抗力系数理论计算值。为了弥补现场试验点数目的限制,对所研究的隧道展开了数值模拟分析。通过对不同的埋深、围岩级别、地质特征下岩石抗力系数现场试验值、理论计算值、数值模拟值和规范值进行对比和综合,提出了高速铁路大断面隧道的围岩抗力系数推荐值,该推荐值突破了普通铁路隧道规范中关于抗力系数建议值仅限于弹性模型的限制,为优化隧道结构设计,充分利用围岩的自承能力提供了理论依据。     

二维介质柱的电磁成像研究

从体等效原理出发得到用介质柱介电参数表示的体等效电流,并得到一个积分方程组求解散射问题．利用变分原理,对此方程组求变分,并化为矩阵方程组,消去含介质柱内总场变化的项,得到散射场变化与介质柱介电参数变化之间关系的矩阵方程．即反演方程．用算例检验此法的反演精度、收敛性能、多目标反演能力、抗噪声性能及利用不完备测量散射信息反演目标的能力．结果表明,此法是一种实用性很强的二维介质柱电磁成像方法．     

基于网络药理学与分子对接探讨“卷柏-猕猴桃根”治疗肺结节的物质基础及作用机制

目的：通过网络药理学方法和分子对接技术,寻找“卷柏-猕猴桃根”药对的主要活性成分,探讨其在肺结节治疗中的作用机制。方法：在TCMSP网站中检索草药卷柏和猕猴桃根,获得两药所含化合物。经过ADME筛选与文献检索,确定药对主要活性化合物。利用PubChem、ChEMBL寻找该药对化合物的预测靶点。利用GeneCard、DisGeNET寻找肺结节的相关基因。利用Venny 2.1在线工具进行韦恩分析,寻找药对与肺结节共有的基因靶点。在OmicShare tools中进行基因本体（GO）功能、京都基因与基因组百科全书（KEGG）通路富集分析。在KEGG ORTHOLOGY数据库中进行基因靶点KO映射。利用分子对接技术验证化合物与预测靶点的对接能力,并进行筛选。在Cytoscape 3.7.1软件中,构建对接成功的“药物-关键化合物-关键靶点-关键通路”网络。结果：本研究共获得9种关键化合物、21个关键靶点。卷柏和猕猴桃根的关键化合物为苏铁黄酮、穗花杉双黄酮、秦皮素、儿茶素、芹菜素、表儿茶素、芦荟大黄素、香草酸、原儿茶酸。关键靶点为磷脂酰肌醇-4,5-二磷酸3-激酶催化亚单位δ（PIK3CD）、磷酸二酯酶4D（PDE4D）、热休克蛋白90α家族A类成员1（HSP90AA1）、醛酮还原酶家族1成员B10（AKR1B10）、囊性纤维化跨膜转导调节因子（CFTR）、原癌基因酪氨酸蛋白激酶（ROS1）、髓样细胞白血病蛋白1（MCL1）等,关键作用通路为磷脂酰肌醇-3-激酶-蛋白激酶B（PI3K-Akt）信号通路、叉头框蛋白O（FoxO）信号通路、凋亡（Apoptosis）、环磷酸腺苷（cAMP）信号通路等。结论：“卷柏-猕猴桃根”的多种活性化合物通过作用于多通路的靶点蛋白而发挥治疗肺结节的作用。     

南昆铁路新型、轻型支挡结构的设计与施工

介绍了南昆铁路应用的各种新型,轻型支档结构及其设计与施工经验,并论述了适用条件。     

Effect of Fe2+ ions on polarization behavior of X60 steel in CO2 saturated salty water

The effects of ferrous ions on cathodic and anodic polarization behavior of the X60 steel in CO₂ saturated salty water were studied by potentio-dynamic polarization method. The results show that the reducing current peak of cathodic polarization is affected significantly if FeCl₂ is added to the salty solution of controlled pH, but not the anodic polarization. It is considered that the ferrous ions accelerate the formation of a protective ferrous carbonate film. Films formed by addition of ferrous ions and those formed by ferrous ions produced from steel corrosion have the same forming mechanism. The former can fully meet the formative condition of the film and can play the role of inhibitor.     

A trajectory-oriented carriageway-based road network data model, part 1: Background

Introduction Withthedramaticdevelopmentofpositioning andtelecommunicationtechnologies,lotsoftraj ectorydataofmovingvehiclescanbecalculated,collected,andtransferred.Inthemeanwhile,thisdevelopmentandtheavailabilityoftrajectory datahavealsomotivatedresearche…     

改进的传染型余震序列模型

将有限幂律公式（LPL）应用到传染型余震序列模型（ETAS）中，并对原ETAS模型加以改进。以台湾集集地震早期余震序列为例，对原ETAS模型与改进的ETAS模型进行了对比分析，结果表明改进的ETAS模型要优于原ETAS模型。     

北康-曾母盆地中中新世以来层序地层样式特征探讨

开展地震资料解释,分析上超、下超、顶超等地震反射终止关系、不整合面以及沉积趋势,识别出北康-曾母盆地中中新世以来14个三级层序界面。在层序界面内部,通过层序地层内幕结构刻画和原形剖面恢复,并结合地层堆砌方式,在北康-曾母盆地中中新世以来的层序地层内,划分了海进、高位正常海退、强制海退和低位正常海退4种成因单元。通过进一步研究该4种成因单元内地层结构和相分布关系,提出北康-曾母盆地中中新世以来的3种层序地层样式,即陆架边缘富砂型三角洲进积楔、退积型生物礁和陆架边缘富砂-富泥型退积楔,其中,沉积物源供应量充足且可容空间减小时,发育富砂的三角洲进积楔,陆架边缘-斜坡-盆地区域发育含砂深水扇;而可容空间增量远大于沉积物供应量时,发育退积型生物礁和富砂-富泥退积楔,斜坡-盆地区域含砂深水扇欠发育。     

Distribution and number change of the Littorinid(Gastropoda) on intertidal hard bed in the Jiulong Estuary, Fujian Province

-Among four species of Littorinid, Littorina scabra, L. brevicula, Nodiliitorina millegrana and N. pyramidalis pyramidalis, on the hard intertidal zone in the Jiulong Estuary, Fujian, L. scabra has the most extensive distribution both vertically and horizontally, and the highest anual average density. The uppermost limit of vertical distribution of N. pyramidalis pyramidalis is higher than the other three Littorinid. Desiccation is a main factor affecting the uppermost limit of vertical distribution of the Littorinid. The increasing wave action will raise the uppermost limit vertical distribution of Littorinid. With seasonal changes, the densities of the Littorinid also change in different tidal zonations. Difference in salinity is the main factor affecting the horizontal distribution of the Littorinid in the estuary.     

Evaluation of landscape changes and ecological degradation by GIS in arid regions: a case study of the terminal oasis of the Shiyang River,northwest China

The development and utilization of water and land resources in the Shiyang River basin are the highest among the inland rivers in northwestern China. Using GIS and the landscape structure analysis program FRAGSTATS, landscape metrics of a study area in the lake-district in Minqin Oasis in the lower reaches of Shiyang River basin were calculated and analyzed based on TM images from 1987 to 2001 at class level and landscape level, respectively. Transformation matrix of the landscape mosaics was also examined. The driving forces of landscape changes were analyzed, including the dynamics of runoff and groundwater resources and their exploitation, and influences of policies and market economy. The results showed that: (1) Patch number of farmland and desert decreased, but their mean patch area increased, indicating that reclamation and desertification was very serious in the study area. Contagion index for oasis increased and edge density and landscape diversity were reduced. (2) Farmland and desert areas have enlarged by 1,520.46 and 4,941.27 hm², respectively. This increase was at the cost of woodland and grassland, which shrank by 1,520.46 and 4,941.27 hm², respectively. (3) The net utilization of surface water decreased by 50% in the last 10 years, and dropped to 22.3 × 10⁶ m³ in the later 1990s. Exploitation of groundwater increased remarkably, up to 80 × 10⁶ m³ per year in the last 5 years. (4) The capability of the economic structure to withstand pressures of the market economy has depressed distinctly because of the simplified planting pattern, which is dominated by salinity-enduring cash crops, such as cotton. Based on the above analysis, strategies of ecological reconstruction in the lake-district were suggested.