Total Synthesis of Marine Cyclic Enol-Phosphotriester Salinipostin Compounds

Due to their structural diversity and variety of biological activities, marine natural products have been the subject of extensive study. These compounds, especially phospholipid polycyclic aromatic hydrocarbons, have a wide range of pharmacological applications, including embedded DNA and central nervous system, anti-tumor, anti-virus, anti-parasite, anti-bacterial, and antithrombotic effects. Unfortunately, the insufficient drug sources have limited the development of these compounds. In this study, we isolated salinpostin compounds from a fermentation solution of marine-derived Salinospora sp., which has a common bicyclic enol-phosphotriester core framework, as well as potent and selective antimalarial activities against P. falciparum with EC_(50)=50 nmolL~(-1). The chemical synthesis of these compounds in greater quantities is necessary for their use in bioactivity studies. Thus we explored a short route with high yields and mild reaction conditions, which can generate combinatorial libraries for drug discovery and lead optimization. We developed a new total synthesis method for six cyclic enol-phosphotriester salinipotin compounds and their diastereomers. For the total synthesis of cyclipostin P, we prepared cyclic enol-phosphotriester salinipostin compounds in 10 steps from a readily accessible starting material, 1,3-dihydroxyacetone, and obtained an overall yield of 1.29%. We fully characterized these compounds by proton nuclear magnetic resonance(~1H-NMR), carbon-13 NMR(~(13)C-NMR), and high-resolution mass spectrometry(HRMS) analyses, and found they coincide absolutely with the same compounds reported previously.     

Seismogenic Structures of the 2006 ML4.0 Dangan Island Earthquake Offshore Hong Kong

The northern margin of the South China Sea, as a typical extensional continental margin, has relatively strong intraplate seismicity. Compared with the active zones of Nanao Island, Yangjiang, and Heyuan, seismicity in the Pearl River Estuary is relatively low. However, a ML4.0 earthquake in 2006 occurred near Dangan Island(DI) offshore Hong Kong, and this site was adjacent to the source of the historical M5.8 earthquake in 1874. To reveal the seismogenic mechanism of intraplate earthquakes in DI, we systematically analyzed the structural characteristics in the source area of the 2006 DI earthquake using integrated 24-channel seismic profiles, onshore–offshore wide-angle seismic tomography, and natural earthquake parameters. We ascertained the locations of NW-and NE-trending faults in the DI sea and found that the NE-trending DI fault mainly dipped southeast at a high angle and cut through the crust with an obvious low-velocity anomaly. The NW-trending fault dipped southwest with a similar high angle. The 2006 DI earthquake was adjacent to the intersection of the NE-and NW-trending faults, which suggested that the intersection of the two faults with different strikes could provide a favorable condition for the generation and triggering of intraplate earthquakes. Crustal velocity model showed that the high-velocity anomaly was imaged in the west of DI, but a distinct entity with low-velocity anomaly in the upper crust and high-velocity anomaly in the lower crust was found in the south of DI. Both the 1874 and 2006 DI earthquakes occurred along the edge of the distinct entity. Two vertical cross-sections nearly perpendicular to the strikes of the intersecting faults revealed good spatial correlations between the 2006 DI earthquake and the low to high speed transition in the distinct entity. This result indicated that the transitional zone might be a weakly structural body that can store strain energy and release it as a brittle failure, resulting in an earthquake-prone area.     

碱性玄武岩形成的时限及其地质意义

中国华北克拉通及邻区的早前寒武纪不存在碱性玄武岩。全球范围内碱性玄武岩的形成也存在时限性，它们在中新生代以来相对大量的出现。碱性玄武岩可划分为钾质碱性玄武岩和钠质碱性玄武岩两大类，后者还可作进一步划分。它们在同位素组成和元素组成上存在相互过渡的变化，这与地幔源区外来加入物质的种类和比例不同有关。高压和低程度熔融是所有碱性玄武岩形成的必要条件。研究表明，碱性玄武岩形成具时限性主要与地球热状态从热向冷的历史演化有关。碱性玄武岩的形成需要地幔俯冲作用，可达到相当深度的地幔俯冲作用只是到了太古宙以后才发生，并在中新生代以来达到高潮。     

南海北部新生代构造运动厘定及与油气成藏关系探讨

通过分析并参考前人对南海构造运动的划分方案以及浅水区研究成果,结合深水区取得的最新认识,对新生代以来南海北部的构造运动重新进行厘定,共划分为四次构造运动:晚白垩世末的神狐运动、中始新世末开始的珠琼运动(包括一幕和二幕)、晚渐新世末的南海运动以及中中新世末的东沙运动,并认为这四次构造运动对烃源岩的发育以及油气运聚成藏起着重要的控制作用。     

地震反演技术在西江油田中的应用

地震反演综合应用了测井资料在垂向上的分辨力和地震资料在横向上的连续性以及所包含的丰富的岩性和物性信息,把界面性的地震数据转换成岩层性的测井数据,使其能与钻井、测井直接对比,并以岩层为单元进行地质解释,研究储层特征的空间变化,描述储层的分布特征,为勘探开发提供重要依据。在西江24-3油田的应用中对比各种反演方法的适用性,举例介绍了针对复杂地质情况时反演应用的关键技术环节。根据工区的已知钻井等地质资料,利用反演波阻抗数据体对工区进行了研究,并对储层进行预测。     

重要的海洋测绘成果——南海重磁异常图

在前人工作基础上,校正、处理、整合升华了1987~2007年的南海海洋重磁调查成果,编制完成南海空间重力异常图、南海磁力ΔT异常图两份基础图件,探索了南海磁力ΔZ⊥异常的处理方法,并且获得了可信的南海磁力ΔZ⊥异常图。成果证实,本文编制的南海重力测量图件、磁力测量图件与南海多波束测深测量的结果匹配,这三种地球物理的成果可以互为验证、互为补充,并且与拖网获得的岩石地球物理性质一致,说明所编制的南海海洋测绘图件可信。提出开展多兵种联合的海洋测绘工作建议,这是海洋测绘发展的方向,互为验证、互为补充的海洋测绘成果才能踏实用于海洋资源、海洋地质灾害预测、海防等领域的基础研究,才能为决策提供客观依据。     

纳米生态基在凡纳滨对虾养殖中的应用研究

研究了凡纳滨对虾集约化养殖池塘中挂设不同密度的纳米生态基对养殖水质及对虾生长的影响。试验共使用12口养殖池,生态基的挂设密度分别为0.029,0.043和0.058 m2/m3水体,以不挂设纳米生态基的养殖池为对照。结果表明,挂设纳米生态基能明显降低养殖水体的氨氮、亚硝氮和COD含量,挂设生态基处理组池塘水体中氨氮与对照组之间差异显著(P0.05),亚硝氮在试验第7 d后差异显著(P0.05);纳米生态基能较好的稳定池塘水体的DO水平,增氧时DO增加速度与挂设生态基的密度成正比,增氧关闭时DO减小速度与挂设生态基的密度成反比;生态基能提高凡纳滨对虾产量并有效降低其饵料系数,对虾产量分别比对照组高出0.8%,15.3%,3.2%,饵料系数分别降低17%,40%,26%。当对虾放苗密度为150尾/m2时,在本研究设计的梯度范围内,生态基的最佳挂设密度为0.043 m2/m3水体。     

吉林省某锑矿分离砷的研究

采用以水玻璃、硫酸为主的组合抑制剂,浮砷抑锑。较好地解决了砷锑分离的难题,使锑的精矿含砷降到符合国家质量标准。     

地图空间认知的数学基础

地图作为人类认知客观世界的重要工具,它的出现和发展极大提升了人们获取地理空间知识的效率.地图设计、虚拟地理环境、地理信息系统及新型智能化地图的研究都离不开地图空间认知理论的指导.本文提出地图空间认知应基于数学基础进行研究的观点,并对多种地图空间认知数学模型进行归纳和总结,为地图空间认知研究提供了新视角.     

低空急流对贵州夏季暴雨的作用分析

普查2001—2006年5—8月的贵州暴雨过程,从天气学角度分析了低空急流与贵州夏季暴雨的关系,并分析了低空急流暴雨的动力和热力特征。指出贵州夏季暴雨的产生与低空急流关系密切,在41次暴雨过程中,有40次暴雨过程的产生都伴随有低空急流的出现,只有1次暴雨过程的产生没有低空急流伴随,而低空急流的位置决定了暴雨产生的区域。