基于网络药理学探究补阳还五汤治疗颈椎病的作用机制

目的：基于网络药理学与分子对接技术分析补阳还五汤治疗颈椎病的作用机制。方法：使用TCMSP、化学专业数据库获取补阳还五汤的活性成分,并对潜在靶点进行预测及规范。分别从PharmGKB、DisGeNET、OMIM、GeneCards数据库中得到颈椎病疾病靶点,利用韦恩图获取补阳还五汤与颈椎病的交集靶点。通过CytoScape软件构建中药-活性成分-疾病靶点和蛋白质-蛋白质相互作用（PPI）网络,获得核心有效成分与关键靶点,利用David数据库对潜在靶点进行富集分析。最后运用AutoDock Vina软件对补阳还五汤核心有效成分与关键靶点进行分子对接验证。结果：共获得补阳还五汤治疗颈椎病的有效活性成分97个,包括槲皮素、山柰酚、黄芩素、木犀草素等;交集靶点64个,关键靶点有白细胞介素-6（IL-6）、肿瘤坏死因子（TNF）、丝氨酸/苏氨酸蛋白激酶1（AKT1）、白细胞介素-1B（IL-1B）等;主要涉及肿瘤坏死因子（TNF）、白细胞介素-17（IL-17）、磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（Akt）等信号通路,分子对接结果显示核心有效成分与关键靶点之间结合紧密,为补阳还五汤治疗颈椎病提供相应条件。结论：该研究在总体上预测了补阳还五汤治疗颈椎病的活性成分、靶点和信号通路,作用途径广泛,为下一步的临床应用提供参考及思路。     

DGPS RTK技术在无验潮水下地形测量中的应用初探

本文简要介绍了DGPS RTK技术的基本原理和作业流程，阐明了该技术在无验潮水下地形测量中的适用性，并以除六泾水文大断面的测量为例介绍了利用该技术进行工程实测的过程，通过对实测数据成果的分析，得出一些有益的结论。     

热带地区流场异常与江淮特大暴雨成因的研究

本文通过计算和对比分析，得到１９９１年春、夏江淮地区特大暴雨形成的五个基本特征：西北太平洋上副高显著偏西、偏北；较弱的西南季风与东南气流汇合成强西南气流伸向江淮地区；偏东风与强西南风形成的辐合带在江淮地区维持；江淮地区对流层中下部为强上升运动、上部为辐散；１３０°Ｅ附近南半球向北半球的较强越赤道气流持续。     

Refraction-Diffraction Mathematical Model for Waves With Lateral Energy Transmission Mechanism and Its Verification

To solve problems concerning wave elements and wave propagation, an effective way is the wave energy balance equation, which is widely applied in oceanography and ocean dynamics for its simple computation. The present papaer advances wave energy balance equations considering lateral energy transmission and energy loss as the governing equation for the study of wave refraction-diffraction. For the mathematical model, numerical simulation is made by means of difference method, and the result is verified with two examples.     

The description of a new kind and three new types of medusae nematocysts in the Xiamen Harbour, China

A new kind of nematocyst, heteromorphore, and three new types of nematocysts, microbasic spino-mastigophore, microbasic undulata-mastigophore, microbasic laevis-mastigophore, are described from medusae of the Xiamen Harbour and discussed by comparison with the results of other research workers.     

The intertidal erosion rate of cohesive sediment: a case study from Long Island Sound

Over the past decades, many attempts have been made to generate useful bottom erosion models for the study of cohesive sediment movement. This study addresses some of the key questions involved in determining the functional relationship between erosion rate and bottom shear stress. Current, wave, and turbidity data were collected from a bottom mounted instrument array in a moderately energetic estuarine environment. The bottom shear stress was calculated from a wave–current interaction model. The erosion rate was derived from the observed sediment concentration using a vertical mixing model. Examination of the relationship between erosion rate and bottom stress showed that the erosion rate varied at intertidal frequency. When averaged over the tidal fluctuation, the erosion rate remained approximately constant at low stress, but increased sharply when the shear stress rose above a critical value. This suggests two-stage erosion. The bed has a layered structure, in which a thin layer of loose, high water content material overlies a more consolidated bed. The top layer of high water content material (fluff) was easily disturbed and re-suspended by tidal currents, but the consolidated bottom layer was eroded only under conditions of high shear stress.     

A new type of Shipboard Meteorological Satellite Receiving-processing System

INTRODUCTIONTheSMSRPSisstalledontheshipnavigatingovertheseaandreceivessatellitecloudmapsatanytimetoprovidereliablereal-timedataofmeteorologyandocean.Itisanimportantequipmentforsafeguardofshipnavigation.Chinahasthousandsofoceanicships.Butalmostallships,withonlyveryfewexception,arenotstalledbySMSRPS.Thecausesareasfollows:1.Thetechniqueisverycomplicated.2.Thedevelopmentcostisveryhigh.3.Ifweintroduceforeignequipment,thecostistooexpensive.4.Foreignequipmentanditssoftwarearecompletelyclo…     

黄海区水母类的生态研究

本文根据１９８２年４月２１日～５月１２日，７月２３日～８月５日，１０月１２～３０日在３４°３０′Ｎ以北．１２４°Ｅ以西黄海水域污染现状综合调查中获得的样品和资料，分析了本海区水母类的种类组成，数量分布以及季节变化。调查海区共鉴定有３４种水母，其中优势种有盘形美螅水母Ｃｌｙｔｉａｄｉｓｃｏｉｄａ，四枝管水母Ｐｒｏｂｏｓｃｉｄａｃｔｙｌａｆｌａｖｉｃｉｒｒａｔａ，五角水母Ｍｕｇｇｉａｅａａｔｔａｎｔｉｃａ。秋季（１０月）为水母类总个体数的高峰期（８．６７个／ｍ３）。水母类的分布与水温、盐度密切相关，海流或水团也起重要作用．水母类分布的变更可以反映出沿岸水和外海水相互推移和消长状况。     

利用卫星遥感资料对南海北部陆架海洋表层温度锋的分析

利用7年(1993～1999)月平均的SST卫星遥感资料，分析了南海北部陆架区域海洋表层温度锋在一年中的逐月变化特征，表明南海北部陆架海洋表层温度锋存在明显的季节内变化。结合风场的卫星遥感资料，分析了东北季风对南海北部陆架温度锋的影响，表明东北季风风速的增加有利于温度锋强度的增强。通过对黑潮南海流套入侵较强的1999年2月与流套入侵较弱的1998年2月的SST卫星遥感资料的对比分析，考察了黑潮南海流套的入侵对南海北部陆架温度锋的影响，结果表明黑潮流套的较强入侵能够增加陆架温度锋的强度，对温度锋的走向也会产生一定的影响。     

海带几个不同种的雌性克隆对高温的适应力

每几个不同种的雌性克隆对高温(22℃、24℃、26℃)的适应力有所差异。大西洋沿岸的Laminariahyperhoren和L.sacchrina雌性克隆较太平洋沿岸的L.japonica、L.angustata和L.ochotensis雌性克隆明显地不耐高温,遗传性的不同是造成这种差异的主要原因。这种遗传性差异是海带长期自然选择的结果。同一物种L.japonica和L.japonicaCⅡ两种雌性克隆在24℃条件下,在第24天其死亡率分别是40.2％和25.2％,X~2=12.25,P<0.001,差异是高度显著的,说明这种不同是遗传性不同所致,而且属于物种内部的差异。