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71.
Although the potential use of biomarkers within environmental risk assessment (ERA) has long been recognised their routine use is less advanced compared with clinical human health risk assessment, where a number of familiar biomarkers (such as blood pressure and serum cholesterol) are in common usage. We have examined how biomarkers are incorporated into human health risk assessment and have identified several 'required elements'. These include identification of the (clinical) assessment endpoint at the outset, rational selection of the biomarker(s) (the measurement endpoint), biomarker 'validation' (e.g. QA/QC) and biomarker 'qualification' (evidence linking the measurement and assessment endpoints). We discuss these elements in detail and propose that their adoption will facilitate the routine use of biomarkers in environmental risk assessment. Furthermore, our analysis highlights the need for cooperation between those working with biomarkers within human and environmental risk assessment to exchange best practice between common disciplines for mutual advantage. 相似文献
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Sudip Bhattacharyya M. Coleman Miller Duncan K. Galloway 《Monthly notices of the Royal Astronomical Society》2010,401(1):2-6
Precision measurements of neutron star radii can provide a powerful probe of the properties of cold matter beyond nuclear density. Beginning in the late 1970s, it was proposed that the radius could be obtained from the apparent or inferred emitting area during the decay portions of thermonuclear (type I) X-ray bursts. However, this apparent area is generally not constant, preventing a reliable measurement of the source radius. Here, we report for the first time a correlation between the variation of the inferred area and the burst properties, measured in a sample of almost 900 bursts from 43 sources. We found that the rate of change of the inferred area during decay is anticorrelated with the burst decay duration. A Spearman rank correlation test shows that this relation is significant at the <10−45 level for our entire sample, and at the 7 × 10−37 level for the 625 bursts without photospheric radius expansion. This anticorrelation is also highly significant for individual sources exhibiting a wide range of burst durations, such as 4U 1636–536 and Aql X-1. We suggest that variations in the colour factor, which relates the colour temperature resulted from the scattering in the neutron star atmosphere to the effective temperature of the burning layer, may explain the correlation. This in turn implies significant variations in the composition of the atmosphere between bursts with long and short durations. 相似文献
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James N Galloway 《Geochimica et cosmochimica acta》1979,43(2):207-218
The coastal area investigated of southern California is adjacent to a densely populated, highly industrialized area that injects about 4 × 109l per day of wastewater into the adjacent coastal ocean. The wastewater contains large amounts of Cd, Cr, Co, Cu, Fe, Pb, Mn, Ni, Ag and Zn, primarily associated with the solids, which produce trace metal concentrations in the wastewater praticulates of two to three orders of magnitude greater than the natural marine sediment. The injection of this solid waste into the ocean causes large areas (on the order of 130 km2) of the marine sediment adjacent to the outfall systems to become heavily contaminated with trace metals.Less than 10% of the metals injected from the outfall are present in the contaminated marine sediment of the study area. The remaining 90% are either dissolved out of the waste solids suspended in seawater or transported out of the area by currents while still associated with the particulate matter.The effect on the global geochemical system due to wastewater discharge is not as extensive as on a local scale but is perhaps more important. The ocean injection of metals in municipal wastewater by man is now of the same order of magnitude as the injection of the metals by natural weathering. The global consequences of this are unknown; however while the natural rate of trace metal injection is constant, the anthropogenic contribution will increase with time. 相似文献
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Beach based and in-situ observations of plunging and spilling breakers, with associated localised wind data, have isolated important characteristics regarding breaking waves in the surf zone. Offshore winds enhance the development of plunging breakers; onshore winds, the development of spilling breakers. Extremely strong offshore, or onshore winds, may re-introduce more spilling or plunging breaker-type characteristics, respectively. 相似文献
78.
This study measured aspects of the physiology of juvenile [(<35mm carapace width (CW)] and adult (>60mm CW) Carcinus maenas to test the hypothesis that these different life-history stages exhibit different sensitivities to environmental contamination. Newly-collected juveniles had significantly (P<0.05) lower immunocompetence (phagocytosis and cellular integrity), lower metabolic energy (haemolymph glucose) and increased scope for growth compared with adults. Seven day exposure to a sub-lethal concentration (200microgL(-1)) of pyrene significantly (P<0.01) reduced immunocompetence, elevated basal heart rate and decreased respiration (at rest) for juveniles but had no overall impact on adult crab physiology. Results confirm that physiological differences exist between juvenile and adult shore crabs, and cause juveniles to be more susceptible to the effects of pyrene exposure than adults. Such differences in sensitivity to contamination between life-cycle stages of the same species have to be taken into account during the risk assessment process. 相似文献
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The nonlinear propagation of Alfvén waves on open solar magnetic flux tubes is considered. The flux tubes are taken to be vertical and axisymmetric, and they are initially untwisted. The Alfvén waves are time-dependent axisymmetric twists. Their propagation into the chromosphere and corona is investigated by solving numerically a set of nonlinear time-dependent equations, which couple the Alfvén waves into motions parallel to the initial magnetic field (motion in the third coordinate direction is artificially suppressed). The principal conclusions are: (1) Alfvén waves can steepen into fast shocks in the chromosphere. These shocks can pass through the transition region into the corona, and heat the corona. (2) As the fast shocks pass through the transition region, they produce large-velocity pulses in the direction transverse to B
o. The pulses typically have amplitudes of 60 km s–1 or so and durations of a few tens of seconds. Such features may have been observed, suggesting that the corona is in fact heated by fast shocks. (3) Alfvén waves exhibit a strong tendency to drive upward flows, with many of the properties of spicules. Spicules, and the observed corrugated nature of the transition region, may therefore be by-products of magnetic heating of the corona. (4) It is qualitatively suggested that Alfvén waves may heat the upper chromosphere indirectly by exerting time-dependent forces on the plasma, rather than by directly depositing heat into the plasma. 相似文献