基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制

目的：基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制。方法：应用TCMSP和UniProt数据库平台查询青蛇方组方的有效活性成分及靶基因,与疾病靶基因取交集后构建蛋白质-蛋白质相互作用(PPI)网络;应用DAVID数据库,对潜在核心作用靶点基因进行基因本体（GO）功能、京都基因与基因组百科全书（KEGG）通路富集分析。利用分子对接原理论证青蛇方生物活性成分与核心靶点的分子结合能力。结果：筛选出青蛇方有效成分63种,作用靶点99个;主要有β-谷甾醇、2,4,7-三羟基-9,10-二氢菲、靛蓝素、豆甾醇、色氨酸等关键成分;转录因子AP-1（JUN）、肿瘤坏死因子（TNF）、原癌基因（RELA）、干扰素γ（IFNG）、转化生长因子-β1（TGF-β1）等核心基因。关键信号通路有癌症信号通路、恰加斯病通路、弓形体病通路、脂质和动脉粥样硬化通路等,分子对接结果显示活性成分与核心靶点基因结合能力较强。结论：青蛇方外用可以通过多种活性成分、多种通路有效抑制免疫炎症反应,促进免疫系统正常运行,从而达到治疗湿疹的目的。     

Linear hydromagnetic stability of a differentially rotating non-uniformly stratified fluid layer

Summary Our discussion is concerned with the common effect of the non-uniformity of layer rotation and stratification. We have assumed a model of differential rotation with the upper part of the layer rotating more slowly, the bottom part more quickly. The upper part of the layer is stratified stably, the bottom part unstably.The thermal instabilities are preferred in the strong differential rotation case and they are the most easily excited by a strong magnetic field (10²–10³). The direction of its propagation is westward in the uniformly stratified layer and eastward in the non-uniformly stratified layer.     

新疆第三次荒漠化监测中的问题及其建议

回顾了新疆3次在荒漠化监测中所进行的荒漠化监测与评价指标体系的建立，也是新疆开展荒漠化监测的基础；介绍了以遥感与地理信息为主要技术的荒漠化监测评价的方法；阐述了新疆第三次荒漠化监测中存在的问题。指出目前新疆荒漠化评价存在的主要问题是评价指标的不确定性、评价指标体系的难操作性和遥感数据源选用的随机性，进而对上述问题的解决途径进行了讨论。     

复杂片岩地区桩基工程实践

复杂片岩地区的桩基工程常出现桩基承载力不足的问题。通过对一典型工程实例的分析，探讨了引起桩基承载力不足的主要原因，及在类似地层桩基施工中应注意的问题。     

Tracing leachates at waste sites using geophysical and geochemical modelling

Tracing leachates at landfills is usually carried out using either geophysical methods or chemical analyses of groundwater. There are often problems with fingerprinting pollution sources or clarifying the spreading pattern due to a wide variety of possibilities giving similar anomalies. The aims of the project were to evaluate the advantages of combining results from multigeophysical modelling and statistical/chemical modelling in order to identify pollution sources and the spreading pattern and to test a new technique for chemical fingerprinting. The project was carried out at a landfill in central Sweden using geophysical measurements and modelling of CVES, GPR and VLF as well as chemical modelling using M3 (multivariate mixing and mass balance calculations). The results indicate that by combining geophysical modelling and chemical calculations, the possibilities of fingerprinting the origin of pollution as well as delineating the spreading pattern are significantly increased.     

Assessment of Marine Clay Improvement Under Reclamation Fills by in-situ Testing Methods

In ground improvement projects with prefabricated vertical drains, the duration of the preloading period is set in advance based on the predetermined time rate of consolidation of the compressible layer. If prediction is accurately done, the required degree of consolidation is met at the pre-determined preloading time. As such, there is a requirement for in-situ tests to be carried out just prior to the removal of surcharge to assess the degree of consolidation of the improved ground. In-situ tests were carried out after 23 months of surcharge loading at the In-Situ Test Site within the Changi East Reclamation Project in the Republic of Singapore. In-situ testing works in this research study comprises the use of field vane shear, piezocone, flat dilatometer and self-boring pressuremeter. The in-situ tests were carried out to determine the shear strength and degree of consolidation of the Singapore marine clay at Changi after 23 months of surcharge loading. The In-Situ Test Site consisted of a Vertical Drain Area as well as an untreated Control Area. Both areas were located adjacent to each other and were surcharged simultaneously to the same level and surcharge left in place for a period of 23 months. Comparison was made between the in-situ test results of the Vertical Drain Area and the untreated Control Area.     

紫色丘陵区不同侵蚀沉积地段土壤结构特征

以中国科学院盐亭紫色土农业生态试验站小流域为例，研究不同土壤侵蚀沉积地段（斜坡和沟谷不同部位）的土壤结构特征，以了解侵蚀沉积对土壤结构的影响。结果表明，在植被覆盖较好的坡体顶部，土壤侵蚀较弱，团聚度达到30．1％，MWD变化为3．4mm，土壤结构良好；沟谷底部由于沉积而有较多细土物质并具有适宜的水分条件，有利于土壤团聚体的形成，结构状况亦较好，团聚度达到50．3％，结构保持率为35．4％；而坡腰侵蚀较严重，团聚度仅为13．6％，结构保持率为14．1％，土壤结构状况较差。     

黄衢高速公路K20+500～K21+000段岩溶分布特征及成因分析

在综合分析黄衢高速公路K20 500～K21 000段地质及勘探资料的基础上,分析了外徐塘大桥桥位区的岩溶发育情况及其分布特征,并对本区岩溶发育成因进行了初步探讨。认为岩溶主要发育在河道内,发育程度一般,受构造控制。     

小型水电站建设用地地质灾害评估技术研究——以湄尼多河小型水电站为例

现阶段,地质灾害评估技术人员在评估实践中,往往不注重各评估对象的差异性,采取同一评估模式,结果达不到评估的目的。在对小型水电站进行评估时,野外调查的重点,评估过程中所使用的方法以及危险性现状、预测及综合分区评估等与大型水电站、路线工程、矿山开采、民用建筑等工程有所不同。湄尼多河小型水电站工程位于云南省怒江州福贡县马吉乡境内,地质环境条件复杂,评估级别综合为二级。文章以该电站建设用地地质灾害危险性评估为例,对小型水电站建设用地地质灾害危险性评估的方法与理论进行探讨。