阿霉素性心肌病大鼠左心室肌纤维化程度与缝隙连接蛋白的变化

目的 探讨阿霉素性心肌病大鼠发生心律失常的发病机制。方法 健康wistar雄性大鼠20只,体重200g,适应周围环境1周后,随机将20只wistar雄性大鼠分为对照组（n=10）和阿霉素（ADR）组（n=10）。ADR组的大鼠在1周内进行3次腹腔注射ADR 2mg/kg;同时对照组则进行3次腹腔注射0.9%NaCl （2ml/kg）,停药后让两组大鼠自由饮食4周。7周后对两组大鼠行心脏彩超检测,左心室舒张末径（LVEDd）与左心室收缩末期内径（LVESd）及左心室射血分数（LVEF）,行VG染色观察各组大鼠心肌纤维化情况;扫描电镜染色观察左心室心肌细胞闰盘病理学变化;两组大鼠心肌结缔组织生长因子（CTGF）、转化生长因子β1（TGF-β1）、N型钙黏蛋白（N-cad）、桥粒芯糖蛋白（DSG2）表达应用ELISA法检测;采用Western blot法检测两组大鼠的心肌细胞Cx40 、Cx43、p-Cx43蛋白表达。结果 与对照组相比,阿霉素组大鼠明显出现心室重构,并易出现心律失常;电镜下观察ADR组大鼠心肌细胞闰盘破损严重,间隙增宽,VG染色显示ADR组大鼠病理积分明显高于对照组（P<0.05）;ADR组大鼠相较于对照组大鼠心室肌中CTGF、TGF-β1的表达升高显著,N-cad、DSG2、Cx40、Cx43及p-Cx43的表达明显减低（P<0.05）。结论 ADR组大鼠可能由于心室肌细胞纤维化、闰盘结构受损、缝隙连接重构等原因导致心律失常。     

A method to obtain soil-moisture estimates over bare agricultural fields in arid areas by using multi-angle RADARSAT-2 data

Soil moisture is an important parameter for agriculture, meteorological, and hydrological studies. This paper focuses on soil-moisture estimation methodology based on the multi-angle high-and low-incidence-angle mode RADARSAT-2 data obtained over bare agricultural fields in an arid area. Backscattering of the high-and low-incidence angles is simulated by using AIEM(advanced integral equation model), with the surface-roughness estimation model built based on the simulated data. Combining the surface-roughness estimation model with the backscattering model of the low-incidence-angle mode, a soil-moisture estimation method is put forward. First, the natural logarithm(ln) of soil moisture was obtained and then the soil moisture calculated. Soil moisture of the study area in Dunhuang, Gansu Province, was obtained based on this method; a good agreement was observed between the estimated and measured soil moisture. The coefficient of determination was 0.85, and the estimation precision reached 4.02% in root mean square error(RMSE). The results illustrate the high potential of the approach developed and RADARSAT-2 data to monitor soil moisture.     

机场群航线网络竞合评价方法及实证探讨——以粤港澳大湾区世界级机场群为例

航线网络是机场群市场竞争-合作（竞合）的重要内容。借助图论、集合论、产业经济等理论方法,从整体性市场及交互式市场两个视角探索并建立机场群航线网络竞合关系的量化评价模型,并基于粤港澳大湾区世界级机场群开展实证分析,研究表明：1）从整体市场竞争视角分析,大湾区机场群航点竞合市场由完全垄断市场与弱合作市场主导,但竞争程度在逐步强化;同类通航点的航线竞合指数存在较大的差异性及复杂性,但竞争程度也呈现加剧态势。2）从交互式竞争视角分析,大湾区机场群航线网络的竞合格局整体呈现由合作型向竞争型转变的态势,且航线竞争水平大于通航航点竞争。     

Comparing the seasonal variation of parameter estimation of ecosystem carbon exchange between alpine meadow and cropland in Heihe River Basin, northwestern China

Grasslands and agro-ecosystems occupy one-third of the global terrestrial area. However, great uncertainty still exists about their contributions to the global carbon cycle. This study used various com...     

基于PPT战略的广东省乐昌市生态旅游扶贫模式探讨

以贫困人口受益为出发点,基于有利于贫困人口发展的旅游(Pro-Poor Tourism,PPT)战略,以广东省乐昌市为例,开展适用于中国南方林区生态旅游扶贫开发的发展模式和旅游扶贫产业的发展路径研究.结果表明:1)政府部门、旅游企业、乡村社区和非营利社会组织都应在提升贫困人口参与度、减轻贫困和生态保护方面承担责任,具体...     

Characteristics of precipitation in northern Mauritania and its links with sea surface temperature

This paper deals with the periodic fluctuation of precipitation at three meteorological stations (Atar, Chenguitti, and Akjoujt) in the Adrar and Inchiri provinces in northern Mauritania and its links with sea surface temperature (SST). Trends for these three meteorological stations were evaluated using the Mann–Kendall (MK) nonparametric test, regression analysis, and autocorrelation for persistence analysis. The MK test showed a significant decreasing trend for Akjoujt and an insignificant trend for the other rainfall time series. However, the decreasing linear regression trends were highly significant for the different time series. On the other hand, persistence analysis indicated the presence of a linear Markov type. The cycles found by power spectrum analysis ranged from 0.5 years to about 11 years. The possibility of a connection between precipitation in this region and sunspot numbers was suggested. SST of the Atlantic Ocean, Indian Ocean, and Mediterranean Sea have significant cross-correlations with precipitation in the study area. The El Niño-Southern Oscillation effect was found to be marginal.     

Changes in wheat potential productivity and drought severity in Southwest China

Theoretical and Applied Climatology - Wheat production in Southwest China (SWC) plays a vital role in guaranteeing local grain security, but it is threatened by increasingly frequent seasonal...     

Linking the northern hemisphere sea-ice reduction trend and the quasi-decadal arctic sea-ice oscillation

The nature of the reduction trend and quasi-decadal oscillation in Northern Hemisphere sea-ice extent is investigated. The trend and oscillation that seem to be two separate phenomena have been found in data. This study examines a hypothesis that the Arctic sea-ice reduction trend in the last three decades amplified the quasi-decadal Arctic sea-ice oscillation (ASIO) due to a positive ice/ocean-albedo feedback, based on data analysis and a conceptual model proposed by Ikeda et al. The theoretical, conceptual model predicts that the quasi-decadal oscillation is amplified by the thinning sea-ice, leading to the ASIO, which is driven by the strong positive feedback between the atmosphere and ice-ocean systems. Such oscillation is predicted to be out-of-phase between the Arctic Basin and the Nordic Seas with a phase difference of 3/4, with the Nordic Seas leading the Arctic. The wavelet analysis of the sea ice data reveals that the quasi-decadal ASIO occurred actively since the 1970s following the trend starting in the 1960s (i.e., as sea-ice became thinner and thinner), as the atmosphere experienced quasi-decadal oscillations during the last century. The wavelet analysis also confirms the prediction of such out-of-phase feature between these two basins, which varied from 0.62 in 1960 to 0.25 in 1995. Furthermore, a coupled ice-ocean general circulation model (GCM) was used to simulate two scenarios, one without the greenhouse gas warming and the other having realistic atmospheric forcing along with the warming that leads to sea-ice reduction trend. The quasi-decadal ASIO is excited in the latter case compared to the no-warming case. The wavelet analyses of the simulated ice volume were also conducted to derive decadal ASIO and similar phase relationship between the Arctic Ocean and the Nordic Seas. An independent data source was used to confirm such decadal oscillation in the upper layer (or freshwater) thickness, which is consistent with the model simulation. A modified feedback loop for the sea-ice trend and ASIO was proposed based on the previous one by Mysak and Venegas and the ice/albedo and cloud/albedo feedabcks, which are responsible for the sea ice reduction trend.     

喀什站高空温度资料均一性检验与订正

利用加拿大环境部气候研究中心研发的RHtest均一化检验方法,结合历史台站沿革信息对喀什站各标准等压面高空温度资料进行了均一性检验和分析。结果表明:850～300 hPa共6个层次的高空日温度观测资料序列完整性较好。08时100 hPa月平均温度的缺测率3%,完整性较差,20时100 hPa的完整性最差,缺测率高达11.44%,其他层次的完整性则较好。喀什站温度资料的非均一性主要是由于台站位置变动、观测仪器换型、观测规范变更和辐射误差订正方法的变化引起的。在订正过程中发现,为了保证订正序列的可信度,需要充分考虑到原始观测序列的缺测率。08时年温度序列的断点数量要明显多于20时,08时序列的订正率达到了85.71%,而20时仅有100 h Pa一条序列做了订正。