醒神健脑方治疗非痴呆性血管性认知障碍伴高Hcy血症30例

目的：观察醒神健脑方治疗非痴呆性血管性认知障碍（VCIND）伴高同型半胱氨酸血症（Hcy）的临床疗效。方法：将60例VCIND伴Hcy患者随机分成2组,每组各30 例。对照组予对症治疗,治疗组在其基础上加用醒神健脑方治疗,共治疗8周。比较2组患者治疗前、治疗4周和治疗8周的简易精神状态量表（MMSE）、蒙特利尔认知评估(MoCA)、临床痴呆评定表(CDR)、日常生活自理能力量表(ADL)评分及血浆同型半胱氨酸（Hcy）、中医证候积分。结果：治疗组MMSE、MoCA、CDR、ADL、Hcy、中医证候总积分治疗前后组内比较,差异均有统计学意义（P<0.05或P<0.01）;对照组仅ADL、Hcy治疗前后组内比较,差异有统计学意义（P<0.01）。治疗组治疗8周后MMSE、CDR、ADL、中医证候总积分与对照组比较,及治疗4周后、治疗8周后MoCA、Hcy与对照组比较,差异均有统计学意义（P<0.01或P<0.05）;治疗组治疗后中医证候积分中,思维呆滞、善忘无记、语言紊乱、性情改变、腰膝酸软、头晕耳鸣、肢体困重、唇甲紫暗、二便等均优于对照组（P<0.01或P<0.05）。结论：醒神健脑方可提高VCIND患者的认知功能和日常生活能力,其机制与降低高Hcy对血管的危害、减轻氧化应激反应对血管和神经元的损伤,进而改善脑部供血有关。     

Zinc concentration effect at the organismal,cellular and subcellular levels in the eastern oyster

The purpose of this research was to demonstrate a concentration effect of zinc exposure at organismal, cellular and sub-cellular levels in the eastern oyster and to find associated protein expression signatures (PES) for each concentration of zinc. Oysters were exposed to six concentrations of zinc for 48 h in a controlled environment. At the organismal level, fecal material was observed as a measure of physiological health during metal exposures. At the cellular level, lysosomal destabilization was measured using hemolymph. This cellular response was significant only at the highest concentration, when the fecal index was lowest. Protein responses were monitored in the oyster following exposure to zinc. Gill tissue was excised and homogenized, and then analyzed using two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) and digital image analysis. Protein expression signatures were found to be specific to each concentration. The protein responses were linked to the other biological parameters measured, each of which followed a concentration gradient of zinc.     

胜利海上油田分队计量研究

通过γ射线穿透油、气、水混合物后的透射和散射计数,经理论模拟计算,实现对原油含水率在线计量分析,测量含水率范围为３％－１００％,精度在２％以内。在实际应用过程中,运行稳定,易于操作,特别是修正了由于原油中含气地含水率测量带来的误差,技术和性能指标均已契过以往各种含水测量仪,通过应用,实现了海洋石油开发公司采油一、二分公司和油气集输大队的分队计量,使生产管理水平整体上了一个新台阶。     

黄河口及其邻近海域大型底栖动物的初步研究 (一)生物量

1985年5-6月对黄河口及其邻近海域的27个站进行了大型底栖动物的首航定量调查。调查海域平均生物量为35.28g/m~2,平均密度为557inds/m~2。棘皮动物占总生物量的47.2％,软体动物占34.2％,多毛类和甲壳类分别占7.5％和6.2％。莱州湾的生物量为调查海域平均生物量的3.5倍。河口输入的营养盐在与高密度低营养盐海水混合过程中,逐渐下沉在莱州湾北部,这是控制该海域高生产力的主要因素。     

黄河口及其邻近海域大型底栖动物的初步研究——(二)生物与沉积环境的关系

1985年5—6月对黄河口及其邻近海域的27个站进行了大型底栖动物的首航次定量调查。分别对18种环境因子和68个优势种和习见种所做的聚类分析显示了黄河口水下三角洲与邻近海域的某些差异,并联系沉积环境将所研究海域划分为四个区:黄河口水下三角洲、莱州湾、渤海中部和渤海湾东部。对大型底栖动物与沉积速率的关系也做了初步探讨。     

A General Linear Wave Theory for Water Waves Propagating over Uneven Porous Bottoms

Starting from the widespread phenomena of porous bottoms in the near shore region, considering fully the diversity of bottom topography and wave number variation, and including the effect of evanescent modes, a general linear wave theory for water waves propagating over uneven porous bottoms in the near shore region is established by use of Green‘s scond identity. This theory can be reduced to a number of the most typical mild-slope equations curreutly in use and provide a reliable research basis for follow-up development of nonlinear water wave theory involving porous bottoms.     

Glucuronidation in the polar bear (Ursus maritimus)

Polar bears bioaccumulate lipophilic pollutants, including polychlorinated biphenyls (PCBs), into their bodies from their exclusive diet of marine organisms. Hydroxylated PCB metabolites (OH-PCBs) have been found in plasma, presumably due to CYP-dependent biotransformation of PCBs in liver. Little is known about the phase 2 metabolism of hydroxylated xenobiotics in polar bears. The objective of this study was to examine UDP-glucuronosyltransferase (UGT) activity with OH-PCBs and a hydroxylated polycyclic aromatic hydrocarbon, 3-hydroxy-benzo(a)pyrene (3-OH-BaP), in polar bear liver. Samples of frozen polar bear liver were used to prepare microsomes. UGT activity with 3-OH-BaP in Brij-treated microsomes, measured by a fluorescence assay, was readily measurable with protein concentrations in assay tubes of up to 10 g/ml, but dropped off very sharply at higher protein concentrations. The apparent Km for 3-OH-BaP was 1.71 +/- 0.04 microM, and Vmax 1.26 +/- 0.16 nmol/min/mg protein (mean +/- SD, n=3). UGT activities with a model tetrachloro-OH-PCB (4'-OH-CB72) and a model hexachloro-OH-PCB (4'-OH-CB159) were assayed with [14-C]-UDPGA and separation of the [14-C]-glucuronide by ion-pair extraction and thin-layer chromatography. [14-C]-glucuronide conjugates were readily formed by polar bear liver microsomes in the absence of added substrate, apparently from contaminants present in liver. This phenomenon was not observed using hepatic microsomes from laboratory-held catfish. Glucuronidation efficiency was much higher with 4'-OH-CB72 (Km 7.3 microM; Vmax 1.55 nmol/min/mg) than 4'-OH-CB159 (Km 16.1 microM; Vmax 0.46 nmol/min/mg). The identities of the aglycones present in polar bear liver are not known, but could include OH-PCBs or hydroxylated metabolites of other persistent organic pollutants. This study demonstrates that UGT with high activity for 3-OH-BaP and other substrates is present in polar bear liver.     

AUV重力测量的运动加速度建模及平台优选

针对适合捷联式重力仪的AUV搭载平台的选型问题,基于国内AUV实际航行数据,分析了多推进器组合、推进器和浮力舱组合、推进器和鳍舵组合等3类AUV的定深航行运动特性;推导了AUV水下航行在3个坐标轴方向上对重力仪产生的运动加速度计算公式,得到运动加速度与AUV水下6个自由度运动要素的解析表达式;基于运动加速度分析,讨论了适用于水下移动重力测量的AUV平台和推进装置设计,进行了AUV搭载平台的优选,并给出了重力仪安装位置建议;选定的AUV实验平台实施移动重力测量验证试验重复线精度达到0.42mGal,验证了搭载平台优选的有效性。