健脾解毒活血汤对幽门螺杆菌相关性胃炎脾胃湿热证模型小鼠IL-1β、GAS的影响

目的：观察健脾解毒活血汤对幽门螺旋杆菌相关性胃炎（HAG）脾胃湿热证模型小鼠血清白介素-1β（IL-1β）、胃泌素（GAS）及胃内组织Hp感染数的影响,为研制新型抗Hp感染的中药提供实验依据。方法：选取40只SPF级昆明小鼠为实验对象,将其随机分为空白组、模型组、西药组和中药组,每组各10只。采用Hp菌液灌胃以建立HAG脾胃湿热证小鼠模型,西药组予以奥美拉唑钠肠溶胶囊灌胃,中药组予以健脾解毒活血汤灌胃,均连续给药14d。观察比较各组小鼠血清IL-1β、GAS与胃内组织Hp感染情况。结果：模型组小鼠血清IL-1β、GAS的含量较空白组明显升高（P<0.01,P<0.05）;与模型组比较,中药组和西药组血清IL-1β显著降低（P<0.05,P<0.01）,GAS水平2组无明显差异。模型组小鼠胃组织Hp感染数较空白组明显增加（P<0.01）,中药组和西药组胃组织Hp感染数较模型组显著降低（P<0.05）。结论：健脾解毒活血汤对HAG脾胃湿热证模型小鼠血清IL-1β及Hp感染数有明显改善作用,但对GAS影响不大,在一定程度上可有效治疗脾胃湿热型HAG。     

巴戟天提取物对去卵巢大鼠骨质疏松症的防治作用

目的：探讨巴戟天提取物对实验性骨质疏松症大鼠的影响。方法：健康雄性SD大鼠60只,随机分为假手术组、模型对照组、阳性对照组及巴戟天提取物高、中、低剂量组,每组各10只。对除假手术组外的其余组大鼠通过手术摘除大鼠双侧卵巢建立骨质疏松症模型,造模后分别给予阳性药物碳酸钙D3颗粒0.5mg/kg,巴戟天提取物高、中、低剂量（0.36g/kg、0.18g/kg、0.09g/kg）干预,假手术组与模型对照组给予等体积蒸馏水,每天1次,共90d,剥离右侧股骨测量股骨中心骨密度与远心端骨密度;称量股骨重量,采用原子吸收分光光度法测定骨钙含量。结果：与假手术组比较,模型对照组大鼠骨密度、骨钙含量、血清雌二醇含量均显著降低,血清碱性磷酸酶含量显著升高,差异均有统计学意义（P＜0.01）;与模型对照组比较,巴戟天高剂量组大鼠骨密度及高、中剂量组大鼠骨钙含量、血清雌二醇含量均显著升高,碱性磷酸酶含量显著降低,差异均有统计学意义（P＜0.05或P＜0.01）。结论：巴戟天提取物能够有效阻止骨丢失,促进钙沉积,从而改善骨质疏松症,其作用机制可能与调节雌性激素水平有关。     

Opportunistic-tended life history traits of Siniperca kneri in the Three Gorges Reservoir,China: potential responses to impoundment

Reservoir impoundment changes original fluvial habitats into lentic environments. Fish species adapted to lentic habitats may take the advantage of such habitat changes and show typical life history traits might facilitate the population increase. Siniperca kneri rarely occurred in fishery landing in the Three Gorges Reservoir (TGR) area before its impoundment in 2003, but it is now a dominant species. In this study, a total of 438 females of S . kneri were collected monthly during September 2012 through January 2014 using gill nets in the TGR. The age, growth, and reproductive biology were then investigated, and compared with other S . kneri populations. The standard length at age 1 was 149.9 mm in the TGR, which is larger than the three compared populations (i.e., Sandaohe Reservoir, Xinfengjiang Reservoir, and North River), but smaller than one (the Guishi Reservoir). The youngest mature female in the TGR was age 1, which is younger than that of the two compared populations (i.e., Xinfengjiang Reservoir and the North River). The relative fecundity in the TGR was 140 eggs/g, which is higher than that of the only available compared population (Xinfengjiang Reservoir, 96 eggs/g). Our results demonstrated that S . kneri in the TGR tended to have faster growth in the first year, a younger age at first maturation, and higher reproductive eff ort. We suggest that such opportunistic-tended life history traits might facilitate rapid increase of the population.     

COSMO-SkyMed颜色变换强度RC法南京建设用地变化检测

基于非局部滤波的SAR强度RC合成变化检测法对小图斑、线型地物等动态监测灵敏,且对数据获取无时空基线要求,在多云多雨城市地表要素变化检测中具备潜力。本文研究以多时相SAR强度RC合成图为数据源,提出一种基于色彩空间变换的变化图斑半自动提取方法,即通过色彩空间转换、训练样本选取、监督分类影像分割、变化区域提取4步骤,可实现基于SAR强度图的城市建设用地动态监测与图斑高效更新。选取南京河西新城与江北新区为示范,以最优参数配置（3特征向量与10样本类别）进行试验,实现了优于88%的建设用地查准率指标。     

小波变换和BP神经网络模型在沉降变形监测中的应用研究

变形预测在预报工程险情方面起着关键性的作用,针对施工中需及时、准确地预测变形的问题,本文利用小波变换原理对监测数据进行降噪处理,并采用BP神经网络分析不同训练样本下的预测效果和精度水平。实验结果表明:基于小波消噪后的BP网络模型,以连续的近期观测数据作为训练样本,对下期变形预测精度高,效果好,相对误差很小。因此,小波变换和BP神经网络模型在沉降变形监测工程中能作为预测研究与应用的参考。     

Identification of dissolved and particulate carbonyl compounds produced by marine harmful algal bloom species

Carbonyl compounds, especially polyunsaturated aldehydes (PUAs), are increasingly reported as teratogenic to grazers and deleterious to phytoplankton. While PUAs have been considered to be mainly produced by diatoms after cell wounding, little is known about whether microalgae other than diatoms, particularly harmful algal bloom (HAB)-forming species, produce carbonyl compounds. In this study, we analyzed the carbonyl compounds from eight common HAB-forming species ( Akashiwo sanguinea , Karenia mikimotoi , Karlodinium venefi cum , Margalefi dinium polykrikoides , Prorocentrum donghaiense , P . minimum , Scrippsiella trochoidea , and Heterosigma akashiwo ) using gas chromatography-mass spectrometry in full scan and selected ion monitoring (SIM) modes. Our results show a ubiquitous presence of carbonyl compounds in both dissolved and particulate forms in all species we examined. In the full scan mode, 133 chromatographic peaks were detected from 51 samples altogether. Both the varieties of carbonyl compounds and their quantities were algal species dependent, although most of the carbonyl compounds could not be fully identifi ed according to the mass spectral database only due to the unavailability of enough standards for all analytes. Aided with nine standards in SIM mode, we further identifi ed and quantifi ed all nine aldehydes (2-methyl-2-pentenal, trans-2-nonenal, cis-6-nonenal, 2,6-dimethyl-5-heptenal, trans-2-hexenal, trans-2- decenal, 2,4-heptadienal, trans-trans-2,4-octadienal, and trans-trans-2,4-decadienal). Four of these nine aldehydes were detected in particulate form, which confi rmed that trans-2-nonenal could be produced by K . mikimotoi , Karl . venefi cum , P . donghaiense , P . minimum , S . trochoidea , and H . akashiwo , 2,4-heptadienal and trans-trans-2,4-decadienal by A . sanguinea , M . polykrikoides , and S . trochoidea , and trans, trans-2,4- octadienal by S . trochoidea , respectively. We proved that some dinofl agellate and raphidophyte species could contribute to the pool of carbonyl compounds including PUAs in a marine ecosystem. Some carbonyl compounds, particularly those in high cell quota and/or dissolved concentration, may be related to fi shkilling or allelopathy which needs further identifi cation and quantifi cation.     

BDS静态精密单点定位模糊度固定解精度分析

针对BDS单系统未校准相位延迟(UPD)估计以及不同时长精密单点定位(PPP)模糊度固定对定位精度影响的问题,该文选取56个测站估计UPD,利用未参与UPD计算的8个测站进行不同时长BDS静态PPP模糊度固定实验。结果表明:BDS星间单差宽巷和窄巷UPD在连续时段内具有一定的稳定性,其估计精度满足用于PPP模糊度固定要求。时长越短模糊度固定率越低。以IGS周解为参考值,不同时长模糊度固定解较浮点解三维定位精度均提高12%以上,时长越短模糊度固定解精度提高越显著。因此,模糊度固定是提高BDSPPP定位精度的重要手段。     

利用多频多系统GNSS OEM板卡实现高精度变形监测

针对近年来被广泛应用的多频多系统GNSS OEM板卡,设计并实现了一套基于多频多系统OEM板卡的低成本变形监测系统,包括数据解码、基线处理、网平差和坐标转换等,能够实时获取测站点高精度空间坐标。以某高层建筑形变监测为例,通过串口通信获取板卡多频多系统观测信息,并经过该系统解算,实现了监测点实时定位,且系统成本相比市场上测量型GNSS接收机系统下降了约40%。实验结果表明,该系统解码精度可达0.2 mm,静态模式定位精度可达到平面2 mm以内,高程5 mm以内,动态模式定位精度可达到平面5 mm以内,高程10 mm以内,验证了该系统的可靠性和适用性。     

基于WSR框架的《开发区土地集约利用评价规程》指标体系分析

旨在剖析我国《开发区土地集约利用评价规程》中指标体系存在的问题并提出改进建议。在界定开发区土地集约利用内涵基础上,从要素特征(W维)、利用目标(R维)和评价过程(S维)等3个维度阐述了开发区土地集约利用评价的系统要求,构建关联分析矩阵,对《规程》中评价指标体系的特征差异化、层次完整性和目标关联性等3个方面进行了分析讨论。针对当前《规程》中存在的评价对象混杂、开发区类型需要细化、指标体系不完整、计算方法需修正等问题提出了相应修改建议。     

大别山及其周边现今垂直形变研究

基于1980年、2005年和2015年3期区域精密水准网观测资料,利用线性动态平差模型计算获取大别山地区水准网长期垂直运动速度场图像。研究发现,淮河平原地表下沉较为严重,大别山呈现弱隆升趋势运动,长江谷地边缘地区较大别山区呈现明显的隆升运动。跨郯庐断裂带水准剖面结果显示,垂直运动与地形呈负相关和弱相关。