An aromatase inhibitor and tamoxifen decrease plasma levels of o,p'-DDT and its metabolites in Nile tilapia (Oreochromis niloticus)

The objective of this study was to determine if tamoxifen or an aromatase inhibitor (4-hydroxyandrostenedione; 4-OHA) affected plasma concentrations of o,p' -DDT and its metabolites, o,p'-DDD and o,p'-DDE, in mature tilapia. Male and female tilapia were injected 6 times intraperitoneally with o,p'-DDT (40 mg/kg) alone or in combination with 4-OHA (2 mg/kg) over a 12 day period. An additional group of male fish was injected with tamoxifen (5 mg/kg) plus o,p'-DDT. At the end of the treatment period, plasma samples were extracted and analyzed by GC/ECD. Females injected only with o,p'-DDT had significantly higher levels of o,p'-DDT compared with males. Interestingly, females and males treated concomitantly with o,p'-DDT and 4-OHA or tamoxifen had significantly lower concentrations of plasma o,p'-DDT (about 50%) compared with fish treated with only o,p'-DDT. These initial results suggest that an interaction between endocrine-active compounds occurs in vivo in tilapia and may involve alterations in metabolism of o,p'-DDT.     

The El Salvador earthquakes of January and February 2001: context, characteristics and implications for seismic risk

The small Central American republic of El Salvador has experienced, on average, one destructive earthquake per decade during the last hundred years. The latest events occurred on 13 January and 13 February 2001, with magnitudes M_w 7.7 and 6.6, respectively. The two events, which were of different tectonic origin, follow the patterns of the seismicity of the region although neither event has a known precedent in the earthquake catalogue in terms of size and location. The earthquakes caused damage to thousands of traditionally built houses and triggered hundreds of landslides, which were the main causes of fatalities. The earthquakes have clearly demonstrated trends of increasing seismic risk in El Salvador due to rapid population expansion in areas of high shaking and landslide hazard, exacerbated by deforestation and uncontrolled urbanisation. The institutional mechanisms required for the control of land use and building practice are very weak and present a major obstacle to risk mitigation.     

Interactive discovery of sequential patterns in time series of wind data

Wind speed and direction vary over space and time due to the interactions between different pressures and temperature gradients within the atmospheric layers. Near the earth’s surface, these interactions are modulated by topography and artificial structures. Hence, characterizing wind behaviour over large areas and long periods is a complex but essential task for various energy-related applications. In this study, we present a novel approach to discover wind patterns by integrating sequential pattern mining and interactive visualization techniques. The approach relies on the use of the Linear time Closed pattern Miner sequence algorithm in conjunction with a time sliding window that allows the discovery of all sequential patterns present in the data. These patterns are then visualized using integrated 2D and 3D coordinated multiple views and visually explored to gain insight into the characteristics of the wind from a spatial, temporal and attribute (type of wind pattern) point of view. This proposed approach is used to analyse 10 years of hourly wind speed and direction data for 29 weather stations in the Netherlands. The results show that there are 15 main sequential patterns in the data. The spatial task shows that weather stations located in the same region do not necessarily experience similar wind pattern. For within the selected time interval, similar wind patterns can be observed in different stations and in the same station at different times of occurrence. The attribute task discovered that the repetitive occurrences of chosen pattern indicate as regular wind behaviour at different weather stations that persisted continuously over time. The results of these tasks show that the proposed interactive discovery facilitates the understanding of wind dynamics in space and time.     

Dynamic faulting under rate-dependent friction

We discuss the effects of rate-dependent friction on the propagation of seismic rupture on active faults. Several physicists using Burridge and Knopoff's box and spring model of faulting have proposed that fault complexity may arise from the spontaneous development of a self-similar stress distribution on the fault plane. If this model proves to be correct, it has important consequences for the origin of the complexity of seismic sources. In order to test these ideas on a more realistic earthquake model, we developed a new boundary integral equation method for studying rupture propagation along an antiplane fault in the presence of nonlinear rate-dependent friction. We study rupture dynamics of models with single and twin asperities. In our models, asperities are places on the fault with a higher value of prestress. Othewise all fault parameters are homogeneous. We show that for models with such asperities, a slip velocity weakening friction leads to the propagation of supersonic healing phases and to the spontaneous arrest of fracture if the prestress outside the asperities is low enough. For models with asperities, we can also observe narrow slip velocity pulses, qualitatively similar to the so-called Heaton pulses observed in some earthquake accelerograms. We also observe a complex distribution of stress after the rupture that depends on details of the initial distribution of asperities and on the details of the friction law.     

Intermediate and deep earthquakes in Spain

Recent improvements in the seismological networks on the Ibero-Maghrebian region have permitted estimation of hypocentral location and focal mechanisms for earthquakes which occurred at South Spain, Alboran Sea and northern Morocco of deep and intermediate depth, with magnitudes between 3.5 and 4.5. Intermediate depth shocks, range from 60 to 100 km, with greater concentration located between Granada and Málaga. Fault-plane solutions of 5 intermediate shocks have been determined; they present a vertical plane in NE-SW or E-W direction. Seismic moments of about 10¹⁵ Nm and dimensions of about 1 km have been determined from digital records of Spanish stations.P-wave forms are complex. This may be explained by the crustal structure near the station, discontinuities in the upper mantle and inhomogeneities near the source. Deep activity at about 650 km has only 3 shocks since 1954 (1954, 1973, 1990). Shocks are located at a very small region. Fault-plane solutions show a consistent direction of the pressure axis dipping 45° in E direction. For the 1990 shock seismic moment is 10¹⁶ Nm and dimensions 2.6 km. TheP-waves are of simpler form with a single pulse. The intermediate and deep activities are not connected and no activity has been detected between 100 and 650 km. The intermediate shocks may be explained in terms of a recent subduction from Africa under Iberia in SE direction. The very deep activity must be related to a sunk detached block of lithospheric material still sufficiently cold and rigid to generate earthquakes.     

Brazilian health regions and scales: A geographical perspective

Abstract:  This paper offers a geographical perspective on the way in which health regions have been defined and established in São Paulo as part of overall Brazilian health policy. To accomplish this, I first situate the Brazilian case in the international debate over the regionalization of health services. Second, I examine health regionalization in the case of São Paulo and show how the process is dynamic and complex, involving geographical scales that go well beyond the administrative boundaries of Brazilian municipalities.