Echinoside A from Pearsonothuria graeffei Exert the Cytotoxicity to MDA-MB-231 Cells via Mitochondrial Membrane and Modulation of PI3K/Akt/mTOR Pathway

A kind of triterpene glycosides echinoside A(EA) was extracted from sea cucumber Pearsonothuria graeffei, and its yield was about 0.78%. The purity of EA was 99.0%, and its molecular weight was 1206 Da. EA was a linear tetrasaccharide attached to a pentacyclic triterpene aglycon. It inhibited the growth of MDA-MB-231 cells in vitro. The antitumor effect was related to elevate ROS level, decrease mitochondrial membrane potential, enhance caspase-3 expression, induce cells apoptosis and arrest cel...     

PI3K/Akt pathway is involved in the activation of RAW 264.7 cells induced by hydroxypropyltrimethyl ammonium chloride chitosan

Journal of Oceanology and Limnology - We previously demonstrated that 2-hydroxypropyltrimethyl ammonium chloride chitosan (HACC) promoted the production of nitric oxide (NO) and proinflammatory...