共查询到18条相似文献,搜索用时 203 毫秒
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二色桌片参的化学成分研究:Ⅲ、二色桌片参多糖—1——岩藻聚糖的免疫调节 总被引:3,自引:0,他引:3
研究了二色桌片参多糖-1(PMI-1)在体内、体外的免疫调节作用。结果表明。二色桌片参多糖-1体外能促进小鼠脾淋巴细胞增殖,促进小鼠脾淋巴细胞分泌IL-2;体内能显著促进迟发型敏反应,增加脾指数,胸腺指数:具有显著的免疫增强作用。 相似文献
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皱纹盘鲍多糖抗肿瘤药理作用研究 总被引:6,自引:0,他引:6
对从软体动物皱纹盘鲍HaliotisdiscushannaiIno中分离提取的纯多糖进行了抗肿瘤活性研究。药理实验表明,多糖对体外培养的小鼠移植性肿瘤肉瘤S180,肝癌HepA细胞无细胞毒作用,但能明显延长HepA小鼠的生存时间,抑制小鼠移植性肉瘤S180的生长,在抑瘤的同时,能明显提高免疫器官胸腺,脾脏的重量,降低荷瘤小鼠肝脏中过氧化脂质的水平,提示鲍鱼多糖可能是通过增强荷瘤小鼠的免疫功能和抗氧 相似文献
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本文以~3H—TdR掺入法观察911对小鼠脾淋巴细胞增殖反应的影响并用CTLL细胞检测了其对IL—2的作用。体外实验结果表明,911对小鼠脾淋巴细胞增殖反应有明显的增强作用,以0.5μg/ml的浓度效果最为明显,相对增殖指数RPI可达200%;体内实验则以5mg/kg体重ip,连续7d效果最好,相对增殖指数RPI可达176%;911用药组小鼠IL—2的产生量均高于对照组,以5mg/kg和10mg/kg效果最好。以上实验证明,这一多糖是一种有希望的新免疫调节药物。 相似文献
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壳聚糖基水凝胶对肿瘤在体内外生长的影响研究 总被引:1,自引:0,他引:1
本文介绍壳聚糖基水凝胶(CH)对肿瘤生长的影响。用MTT法检测水凝胶对Hela及SGC-7901两种肿瘤细胞体外生长增殖的影响。建立小鼠移植性肿瘤S180实体瘤模型,通过腹腔注射给药研究水凝胶的体内抑瘤效果。结果表明水凝胶能轻微抑制肿瘤细胞的体外生长,提高荷瘤小鼠免疫器官指数和细胞因子水平,显著抑制荷瘤小鼠体内肿瘤组织的生长。说明壳聚糖基水凝胶对肿瘤在体内外的生长具有一定抑制作用。 相似文献
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亨氏马尾藻硫酸多糖抗肿瘤活性的研究 总被引:12,自引:0,他引:12
近年来,不少学者研究证明,昆布科水石昆布、真昆布和马尾藻科鼠尾藻、海黍子等海藻的抽提物具有抗肿瘤作用。本文选用广东、福建两省特有的亨氏马尾藻(Sargassumhenslowianum)为原料,对其提取物的成分和抗肿瘤活性进行了研究,为寻找新的保健食品原料和医药工业原料提供了依据。1 材料与方法1.1 材料亨氏马尾藻 1994年10月,1995年10月采自广东省海丰县硫酸多糖 从亨氏马尾藻中提取实验动物 由第一军医大学提供的雄性纯种昆明小鼠,体重20±2g,随机分组。瘤株 艾氏腹水瘤(EAC)瘤株、腹水型肉瘤S180由中山医科大学提供。1.2 方法1.2.1… 相似文献
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含硒紫球藻胞外多糖的制备及对体内外肿瘤细胞生长的影响 总被引:4,自引:0,他引:4
采用在培养液中添加亚硒酸来实现藻对无机硒的富集和转化,制备一种含硒的紫球藻(Porphyridiumsp.)胞外多糖(Se-PSP);通过DAN荧光法测硒含量及红外光谱,对硒是否结合在多糖上进行了初步探讨;用四唑盐比色法(MTT)研究了不同浓度含硒的紫球藻胞外多糖对3种体外肿瘤细胞生长的影响。通过建立荷瘤小鼠模型,研究了含硒多糖对腹水瘤S180的作用。结果表明含硒的胞外多糖含硒量约为0.015mg/g,40,80mg/LSe-PSP对3种肿瘤细胞SMMC7721、A549、A357均有一定程度的抑制作用,尤其是对SMMC7721抑制程度最为明显。荷瘤小鼠模型实验结果表明100mg/(kg.·d)Se-PSP可以延长荷瘤小鼠的生存时间,Se-PSP有可能成为一种抗肿瘤药物。 相似文献
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日本刺参的抗肿瘤及免疫调节作用研究 总被引:8,自引:1,他引:7
采用日本刺参(Apostichopus japonicus)浆灌胃移植性肿瘤模型小鼠,探讨了日本刺参的抗肿瘤作用及其对免疫功能的调节作用。结果表明,日本刺参各剂量组均能显著抑制小鼠S180肉瘤的生长,提高小鼠脾指数及胸腺指数(P〈0.05);显著提高荷瘤小鼠血清溶血素含量(P〈0.01)和抗体形成细胞数(P〈0.05);提高迟发型变态反应水平和脾淋巴细胞转化能力(P〈0.05,P〈0.01);促进NK细胞活性和巨噬细胞的吞噬能力(P〈0.05。P〈0.01)。提示日本刺参能全面调节机体的特异性和非特异性免疫功能.控制和杀灭肿瘤细胞。 相似文献
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从8种微藻中制备水溶和脂溶性的提取物,用来筛选抗菌和抗肿瘤活性.抗菌活性是用抑菌豳法(细菌用金黄色葡萄球菌,枯草芽孢杆菌和大肠杆菌为指示菌,真菌用黑曲霉和产黄青霉为指示菌).实验选用的所有的微藻均有不同程度的抗一种或多种菌活性,抗金黄色葡萄球菌微藻提取物中的57.14%有抗耐甲氧西林金黄色葡萄球菌活性,采用MTT法体外... 相似文献
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为探究轴压作用下双金属复合海底管道的组合作用与承载性能,对双金属复合海底管道进行了试验研究和理论分析。开展了不锈钢衬管材料性能试验,对比了国际主流不锈钢本构关系模型和试验结果。利用ABAQUS建立了精细化的双金属复合管道轴压试验有限元模型,系统研究了关键参数如复合工艺产生的环向复合应力、钢管初始缺陷幅值等对双金属复合管在轴压作用下力学性能的影响规律。通过对比已有轴压双金属复合管道试验结果,验证有限元模型。基于验证的有限元模型,对轴压作用下双金属复合管道的组合作用以及径厚比和材料强度对承载力的影响进行了分析。结果表明双金属复合管道的轴压极限承载力主要取决于基管的截面屈服荷载,并随着管径和材料强度的提高而增大。并依据分析结果对双金属复合海底管道的设计提出建议。 相似文献
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Yan Chi Zhang Jianguo Yan Shuwang
Lecturer Dept. of Hydraulic Eng. Tianjing University Tianjin
Professor Dept. of Hydraulic Eng. Tianjing University Tianjin 《中国海洋工程》1994,(4)
- Based on the theory of limit analysis, the Finite Difference Method (FDM) is established for evaluating the ultimate bearing capacity of subsoils to bear the unburied pipelines. The analytical results of bearing capacity of the ideal clay is given. The approach to bearing capacity evaluation of cohesionless subsoils without surcharge is suggested. The results from this method are consistent with those obtained from model tests. 相似文献
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采用四甲基偶氮唑盐(MTT)法体外肿瘤细胞株抑制试验,研究耳壳藻内酯合成过程中结构的衍化物和抗肿瘤活性的关系。结果表明.耳壳藻内酯对小鼠肝细胞癌(H22)、小鼠路易斯肺癌(LLC)、人宫颈癌(Hela)和人乳腺癌(MCF-7)有较强的细胞毒性,对正常小鼠胚成纤维(NIH3T3)和人肝细胞(L—02)的毒性较低。酮基内酯对各肿瘤细胞毒性差异较大,对上述正常细胞株的杀伤力也较大。体外结合DNA的研究表明,耳壳藻内酯芳香环上的羟基较酮基内酯上的酮基易于插入DNA分子中.造成DNA分子的断裂和解聚。标记代谢物前体掺入试验表明,耳壳藻内酯能够显著抑制DNA大分子的合成,阻滞肿瘤细胞的生长。推测耳壳藻内酯芳香环上的羟基是影响其抗肿瘤活性的主要官能团。 相似文献
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A lumped-parameter model was developed to predict the response of an ocean bottom seismometer, resting on relatively non-stiff sediments, to vertical ground-motion. The model predictions were compared with the response of an instrument on a foundation of foam rubber to a sinusoidal input. Comparison of the model data to the measured Lopez Island vertical transient test data showed that bearing pressure of the instrument in a nonuniform vertical soil profile causes certain instruments to experience a shear modulus higher than the mean. 相似文献
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Deep cement mixing (DCM) technique is a deep in-situ stabilization technique by mixing cement powder or slurry with soft soils below the ground surface to improve their properties and behavior. Some of DCM treated soft soil grounds are approximately in a plane-strain condition; for example, a fill embankment on DCM improved ground. In this study, a plane-strain physical model was created with instrumentation and used to investigate the bearing capacity and failure mode of a soft soil improved by an end-bearing DCM column group. This study focuses on the observed wedge-shaped shear failure of the model ground and attempts to give an account of the failure. Two different methods are used to calculate the bearing capacity of the model ground, and the computed values are compared with the measured ones. It is found that the simple Brom's method gives a better estimate of the bearing capacity of the present model ground. It is also found that measured data of pore water pressures at different locations in the soft soil indicate coupling between failure of columns and consolidation of the soft soil. This study has presented the first time that a wedge-shaped block failure was observed for pattern of DCM treated soil ground. 相似文献
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目前海洋石油导管架平台桩基础的轴向极限承载力常用的设计方法为API RP2A(美国石油协会)和静力触探(CPT)的方法.在这两种方法的基础上,提出了用BP神经网络模型对桩的轴向极限承载力进行计算的思路,能够有效地预测桩的轴向极限承载力.根据BP神经网络算法具有较强的非线性映射能力和学习功能的特点,通过对影响单桩极限承载力因素的分析,依据静力触探资料建立了基于BP神经网络的单桩轴向极限承载力预测模型.通过利用API RP2A方法分析成果对该模型进行学习训练和预测检验,证明了预测模型性能良好、具有较高的精度和收敛速度快等特点,验证了神经网络方法的可行性,预测结果能够指导桩基础设计,缩短周期.因而具有较大的工程实用价值. 相似文献
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Ahmad Safuan A Rashid Mohammad Gharehzadeh Shirazi Ramli Nazir Hisham Mohamad Fauzan Sahdi 《Marine Georesources & Geotechnology》2020,38(6):755-760
AbstractThis article presents the performance of the short-term bearing capacity on soft clay soil treated by Kenaf geotextile under vertical loading via a small-scale modelling test at unit gravity. The ground model was formulated by consolidating kaolin in a rigid testing compartment. In the loading test, the strip footing was represented by a rigid footing. For the treated case, a series of tests were performed to examine the effects of the burial depth of the Kenaf geotextile on the bearing capacity of the soft soil. The Kenaf geotextile was laid beneath the rigid footing (at the ground surface) and at 50, 75 and 100?mm depth from the soil surface. All the measured results of the Kenaf geotextile treated ground were compared with the untreated ground. The incorporation of Kenaf fibre geotextile was observed to enhance the bearing capacity of soft cohesive clay up to 281% depending upon the depth of the installed geotextile. The geotextile at the surface provided the highest bearing capacity and sustained the highest displacement at failure. The outcome of this research will promote the use of natural fibre geotextiles as sustainable earth reinforcement in temporary earthwork applications. 相似文献